The first mitotic division of human embryos is highly error prone

Autor: Cerys E. Currie, Emma Ford, Lucy Benham Whyte, Deborah M. Taylor, Bettina P. Mihalas, Muriel Erent, Adele L. Marston, Geraldine M. Hartshorne, Andrew D. McAinsh

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Human beings arise from serial mitotic divisions of a single fertilised egg. Here through live cell imaging of fertilized embryos the authors show that the first mitotic division is error prone and can contribute to preimplantation mosaicism.

Externí odkaz: https://doaj.org/article/070a5d4d39354b38a6e1e9964ca0f05e

Bayesian inference of multi-point macromolecular architecture mixtures at nanometre resolution.

Autor: Peter A Embacher, Tsvetelina E Germanova, Emanuele Roscioli, Andrew D McAinsh, Nigel J Burroughs

Publikováno v: PLoS Computational Biology, Vol 18, Iss 12, p e1010765 (2022)

Gaussian spot fitting methods have significantly extended the spatial range where fluorescent microscopy can be used, with recent techniques approaching nanometre (nm) resolutions. However, small inter-fluorophore distances are systematically over-es

Externí odkaz: https://doaj.org/article/911f5eba65ac492a9901c38a7287b687

Ensemble-Level Organization of Human Kinetochores and Evidence for Distinct Tension and Attachment Sensors

Autor: Emanuele Roscioli, Tsvetelina E. Germanova, Christopher A. Smith, Peter A. Embacher, Muriel Erent, Amelia I. Thompson, Nigel J. Burroughs, Andrew D. McAinsh

Publikováno v: Cell Reports, Vol 31, Iss 4, Pp - (2020)

Summary: Kinetochores are multi-protein machines that form dynamic attachments to microtubules and control chromosome segregation. High fidelity is ensured because kinetochores can monitor attachment status and tension, using this information to acti

Externí odkaz: https://doaj.org/article/786ffb97659f4948ad237de50c3a4a33

The Four Causes: The Functional Architecture of Centromeres and Kinetochores

Autor: Andrew D. McAinsh, Adele L. Marston

Publikováno v: Mcainsh, A D & Marston, A L 2022, ' The four causes : The functional architecture of centromeres and kinetochores ', Annual review of genetics, vol. 56, no. 1, pp. 279-314 . https://doi.org/10.1146/annurev-genet-072820-034559

Kinetochores are molecular machines that power chromosome segregation during the mitotic and meiotic cell divisions of all eukaryotes. Aristotle explains how we think we have knowledge of a thing only when we have grasped its cause. In our case, to g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e8f4f00b6a230fa6af5493fb78b4a2
https://doi.org/10.1146/annurev-genet-072820-034559

Unique geometry of sister kinetochores in human oocytes during meiosis I may explain maternal age-associated increases in chromosomal abnormalities

Autor: Jessica Patel, Seang Lin Tan, Geraldine M. Hartshorne, Andrew D. McAinsh

Publikováno v: Biology Open, Vol 5, Iss 2, Pp 178-184 (2016)

The first meiotic division in human oocytes is highly error-prone and contributes to the uniquely high incidence of aneuploidy observed in human pregnancies. A successful meiosis I (MI) division entails separation of homologous chromosome pairs and c

Externí odkaz: https://doaj.org/article/3b17757d03d6437899618351c5867271