Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Andrew D Huber"'
Autor:
Andrew D Huber, Taosheng Chen
Publikováno v:
eLife, Vol 13 (2024)
Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.
Externí odkaz:
https://doaj.org/article/b16b80b60257436494e018ade1aa353c
Autor:
Maritza Puray-Chavez, Philip R. Tedbury, Andrew D. Huber, Obiaara B. Ukah, Vincent Yapo, Dandan Liu, Juan Ji, Jennifer J. Wolf, Alan N. Engelman, Stefan G. Sarafianos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Technical limitations in simultaneous microscopic visualization of HIV transcription from individual integration sites have curtailed progress in the field. Here the authors report a branched DNA in situ hybridization method for direct single-cell vi
Externí odkaz:
https://doaj.org/article/1c1971c8f6e44462b70f027522cf0fa9
Publikováno v:
Drug Metabolism and Disposition. 51:228-236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a7f3bdd1615dbea4bd7a04235d49d0
https://doi.org/10.1124/dmd.122.000858
https://doi.org/10.1124/dmd.122.000858
Autor:
Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4f5fdd0de0b842ec1a1ac43f4309d0
https://doi.org/10.1124/jpet.122.524030
https://doi.org/10.1124/jpet.122.524030
Autor:
Dandan Liu, Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice, Robert Ralston, Philip R. Tedbury, Stefan G. Sarafianos
Publikováno v:
Viruses; Volume 15; Issue 4; Pages: 981
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af18009a3ee9e1260b54726b30d051b5
Autor:
Wenwei Lin, Andrew D. Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ligand-binding promiscuity in detoxification systems protects the body from toxicological harm but is a roadblock to drug development due to the difficulty in optimizing small molecules to both retain target potency and avoid metabolic events. Immens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d3c89847d715fe6e44247b4f80407a
https://doi.org/10.1073/pnas.2217804120
https://doi.org/10.1073/pnas.2217804120
Autor:
Andrew D. Huber, Jennifer J. Wolf, Dandan Liu, Anna T. Gres, Jing Tang, Kelsey N. Boschert, Maritza N. Puray-Chavez, Dallas L. Pineda, Thomas G. Laughlin, Emily M. Coonrod, Qiongying Yang, Juan Ji, Karen A. Kirby, Zhengqiang Wang, Stefan G. Sarafianos
Publikováno v:
mSphere, Vol 3, Iss 2 (2018)
ABSTRACT Heteroaryldihydropyrimidines (HAPs) are compounds that inhibit hepatitis B virus (HBV) replication by modulating viral capsid assembly. While their biophysical effects on capsid assembly in vitro have been previously studied, the effect of H
Externí odkaz:
https://doaj.org/article/d21fb67e4b2b429c9a5549748928bef6
SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1
Autor:
Andrew D. Huber, Yongtao Li, Wenwei Lin, Annalise N. Galbraith, Ashutosh Mishra, Shaina N. Porter, Jing Wu, Rebecca R. Florke Gee, Wei Zhuang, Shondra M. Pruett-Miller, Junmin Peng, Taosheng Chen
Publikováno v:
ACS medicinal chemistry letters. 13(8)
We previously reported a specific inverse agonist (SPA70) of the nuclear receptor pregnane X receptor (PXR). However, derivatization of SPA70 yielded only agonists and neutral antagonists, suggesting that inverse agonism of PXR is difficult to achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1d8fb46aaa102abe7cbc97b7e624fa
https://pubmed.ncbi.nlm.nih.gov/35978691
https://pubmed.ncbi.nlm.nih.gov/35978691
Autor:
Monicah N Bwayi, Efren Garcia-Maldonado, Sergio C Chai, Boer Xie, Shirish Chodankar, Andrew D Huber, Jing Wu, Kavya Annu, William C Wright, Hyeong-Min Lee, Jayaraman Seetharaman, Jingheng Wang, Cameron D Buchman, Junmin Peng, Taosheng Chen
Publikováno v:
Nucleic acids research. 50(6)
The 48 human nuclear receptors (NRs) form a superfamily of transcription factors that regulate major physiological and pathological processes. Emerging evidence suggests that NR crosstalk can fundamentally change our understanding of NR biology, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025ac0ee2762b893477d7d6fd92904f2
https://pubmed.ncbi.nlm.nih.gov/35212371
https://pubmed.ncbi.nlm.nih.gov/35212371
Autor:
Yongtao Li, Jing Wu, Sergio C. Chai, Andrew D. Huber, Monicah Bwayi, Taosheng Chen, Wenwei Lin
Publikováno v:
Molecular Pharmacology. 97:180-190
The xenobiotic receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are activated by structurally diverse chemicals to regulate the expression of target genes, and they have overlapping regulation in terms of ligands and tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44258ba6df195bdf5398fbfc5dc242e6
https://doi.org/10.1124/mol.119.118513
https://doi.org/10.1124/mol.119.118513