Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Andrew D Huber"'
Autor:
Efren Garcia-Maldonado, Andrew D. Huber, Sergio C. Chai, Stanley Nithianantham, Yongtao Li, Jing Wu, Shyaron Poudel, Darcie J. Miller, Jayaraman Seetharaman, Taosheng Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Nuclear receptors are ligand-activated transcription factors that can often be useful drug targets. Unfortunately, ligand promiscuity leads to two-thirds of receptors remaining clinically untargeted. PXR is a nuclear receptor that can be act
Externí odkaz:
https://doaj.org/article/c30e189d2e734c8aad1bc9b3e758e589
Autor:
Andrew D Huber, Taosheng Chen
Publikováno v:
eLife, Vol 13 (2024)
Complementary structural biology approaches reveal how an agonist and a covalent inhibitor simultaneously bind to a nuclear receptor.
Externí odkaz:
https://doaj.org/article/b16b80b60257436494e018ade1aa353c
Autor:
Ming Shao, Qingfei Pan, Haiyan Tan, Jing Wu, Ha Won Lee, Andrew D. Huber, William C. Wright, Ji-Hoon Cho, Jiyang Yu, Junmin Peng, Taosheng Chen
Publikováno v:
Genes and Diseases, Vol 11, Iss 4, Pp 101079- (2024)
CYP3A5 is a cytochrome P450 (CYP) enzyme that metabolizes drugs and contributes to drug resistance in cancer. However, it remains unclear whether CYP3A5 directly influences cancer progression. In this report, we demonstrate that CYP3A5 regulates gluc
Externí odkaz:
https://doaj.org/article/9ad3267c458a4173bd3a65ec2f9de8f9
Autor:
Rebecca R. Florke Gee, Andrew D. Huber, Jing Wu, Richa Bajpai, Allister J. Loughran, Shondra M. Pruett-Miller, Taosheng Chen
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 11, Pp 4523-4534 (2023)
Pregnane X receptor (PXR) is a ligand-activated nuclear receptor that transcriptionally upregulates drug-metabolizing enzymes [e.g., cytochrome P450 3A4 (CYP3A4)] and transporters. Although the regulation of PXR target genes is well-characterized, le
Externí odkaz:
https://doaj.org/article/5971bd48286446cb86209bac424bd79b
Autor:
Dandan Liu, Tanya P. Ndongwe, Juan Ji, Andrew D. Huber, Eleftherios Michailidis, Charles M. Rice, Robert Ralston, Philip R. Tedbury, Stefan G. Sarafianos
Publikováno v:
Viruses, Vol 15, Iss 4, p 981 (2023)
Several direct-acting antivirals (DAAs) are available, providing interferon-free strategies for a hepatitis C cure. In contrast to DAAs, host-targeting agents (HTAs) interfere with host cellular factors that are essential in the viral replication cyc
Externí odkaz:
https://doaj.org/article/4d194be6b0514626b0df621f63046235
Autor:
Maritza Puray-Chavez, Philip R. Tedbury, Andrew D. Huber, Obiaara B. Ukah, Vincent Yapo, Dandan Liu, Juan Ji, Jennifer J. Wolf, Alan N. Engelman, Stefan G. Sarafianos
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Technical limitations in simultaneous microscopic visualization of HIV transcription from individual integration sites have curtailed progress in the field. Here the authors report a branched DNA in situ hybridization method for direct single-cell vi
Externí odkaz:
https://doaj.org/article/1c1971c8f6e44462b70f027522cf0fa9
Publikováno v:
Drug Metabolism and Disposition. 51:228-236
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19a7f3bdd1615dbea4bd7a04235d49d0
https://doi.org/10.1124/dmd.122.000858
https://doi.org/10.1124/dmd.122.000858
Autor:
Andrew D. Huber, Wenwei Lin, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Cellular and Molecular Pharmacology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce4f5fdd0de0b842ec1a1ac43f4309d0
https://doi.org/10.1124/jpet.122.524030
https://doi.org/10.1124/jpet.122.524030
Autor:
Wenwei Lin, Andrew D. Huber, Shyaron Poudel, Yongtao Li, Jayaraman Seetharaman, Darcie J. Miller, Taosheng Chen
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ligand-binding promiscuity in detoxification systems protects the body from toxicological harm but is a roadblock to drug development due to the difficulty in optimizing small molecules to both retain target potency and avoid metabolic events. Immens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d3c89847d715fe6e44247b4f80407a
https://doi.org/10.1073/pnas.2217804120
https://doi.org/10.1073/pnas.2217804120
Autor:
Andrew D. Huber, Jennifer J. Wolf, Dandan Liu, Anna T. Gres, Jing Tang, Kelsey N. Boschert, Maritza N. Puray-Chavez, Dallas L. Pineda, Thomas G. Laughlin, Emily M. Coonrod, Qiongying Yang, Juan Ji, Karen A. Kirby, Zhengqiang Wang, Stefan G. Sarafianos
Publikováno v:
mSphere, Vol 3, Iss 2 (2018)
ABSTRACT Heteroaryldihydropyrimidines (HAPs) are compounds that inhibit hepatitis B virus (HBV) replication by modulating viral capsid assembly. While their biophysical effects on capsid assembly in vitro have been previously studied, the effect of H
Externí odkaz:
https://doaj.org/article/d21fb67e4b2b429c9a5549748928bef6