Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Andrew D Hope"'
Autor:
Matthew J. Farrer, Sarah Lincoln, Gina Bisceglio, Andrew D Hope, Jennifer M. Kachergus, Mary M. Hulihan, Ronny Myhre
Publikováno v:
Neuroscience Letters. 367:97-100
Missense mutations and genomic multiplications of the α-synuclein gene ( SNCA ) have been linked to autosomal dominant familial Parkinson’s disease. We screened 50 probands of families with autosomal dominant parkinsonism for α-synuclein mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74408cc6115970427004c23a29dfcc20
https://doi.org/10.1016/j.neulet.2004.05.100
https://doi.org/10.1016/j.neulet.2004.05.100
Publikováno v:
Neuroscience Letters. 359:94-98
UBB+1 protein is an aberrant ubiquitin associated with progressive supranuclear palsy (PSP). It leads to proteasome inhibition, heat-shock protein (HSP) expression and apoptosis in cell cultures. Despite UBB+1 polyubiquitination (an indication of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf249262d4c65530dd60b655bb9cd38
https://doi.org/10.1016/j.neulet.2003.12.127
https://doi.org/10.1016/j.neulet.2003.12.127
Autor:
Fred W. van Leeuwen, Andrew D. Hope, Elly M. Hol, David F. Fischer, Andrew J. Lees, Rohan de Silva
Publikováno v:
Journal of Neurochemistry. 86:394-404
Intracellular protein inclusions in Alzheimer's disease and progressive supranuclear palsy contain UBB+1, a variant ubiquitin. UBB+1 is able block the 26S proteasome in cell lines. Proteasome inhibition by drug action has previously been shown to ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e4850de0b05865b3e8db32b3ec86c5
https://doi.org/10.1046/j.1471-4159.2003.01844.x
https://doi.org/10.1046/j.1471-4159.2003.01844.x
Autor:
Andrew D. Hope, Rina Bandopadhyay, Andrew J. Lees, R de Silva, G M Gibb, Brian H. Anderton, C Strand, T Jowett, T Revesz, Nicola Wood, Nadeem A. Khan, Tammaryn Lashley, Diane P. Hanger, JL Holton, Andrew R. Reid, Michelle A. Utton
Publikováno v:
Neuropathology and Applied Neurobiology. 29:288-302
Pathological inclusions containing fibrillar aggregates of hyperphosphorylated tau protein are a characteristic feature in the tauopathies, which include Alzheimer's disease, frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f62d05efaf43503167fdaca47afe415
https://doi.org/10.1046/j.1365-2990.2003.00463.x
https://doi.org/10.1046/j.1365-2990.2003.00463.x
Autor:
Andrew D. Hope, Alan M. Pittman, Michael E. Weale, Huw R. Morris, Nicholas W. Wood, Andrew J. Lees, R de Silva
Publikováno v:
Neurology. 61:407-409
Recent reports are inconclusive in showing that the Q7R polymorphism of the novel Saitohin gene, nested in intron 9 of the tau gene, is associated with AD. The authors show that this polymorphism is in complete linkage disequilibrium with the extende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09cffcbd97a5c5ccc8ed7f2db0f361b6
https://doi.org/10.1212/01.wnl.0000073140.25533.90
https://doi.org/10.1212/01.wnl.0000073140.25533.90
Autor:
Sina Ogholikhan, Jada Lewis, Zhen He, Rajendra K. Pandey, Heather L. Melrose, Demetrius M. Maraganore, Andrew D Hope, Adam Braithwaite, Kelly M. Hinkle, Caroline Kent, Ivanka Toudjarska, David Bumcrot, Cynthia Zehr, Klaus Charisse, Julia E. Crook, Ravi Braich, Michael G. Heckman, Sarah Lincoln, Matthew J. Farrer
Publikováno v:
Molecular Neurodegeneration, Vol 3, Iss 1, p 19 (2008)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Overexpression of α-synuclein (SNCA) in families with multiplication mutations causes parkinsonism and subsequent dementia, characterized by diffuse Lewy Body disease post-mortem. Genetic variability in SNCA contributes to risk of idiopat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a47dd0fdb5e7186d90afade9a1b04d0
http://www.molecularneurodegeneration.com/content/3/1/19
http://www.molecularneurodegeneration.com/content/3/1/19
Autor:
Rohan de Silva, Hiroyashi Ariga, Ann E. Kingsbury, Andrew J. Lees, Andrew D. Hope, A.J. Leonard, John Hardy, Patrick M. Abou-Sleiman, Alan M. Pittman, Nicholas W. Wood, Mark R. Cookson, Tamas Revesz, Rina Bandopadhyay, Ian M. Evans, C Strand, Rosa M. Canet-Avilés, Andrew R. Reid, Daniel G. Healy, Tammaryn Lashley, Chris McLendon, David Miller
Publikováno v:
Brain : a journal of neurology. 127(Pt 2)
Two mutations in the DJ-1 gene on chromosome1p36 have been identified recently to cause early-onset, autosomal recessive Parkinson's disease. As no information is available regarding the distribution of DJ-1 protein in the human brain, in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fed98606c68437ad854722d95b476be
https://pubmed.ncbi.nlm.nih.gov/14662519
https://pubmed.ncbi.nlm.nih.gov/14662519
Autor:
Andrew D, Hope, Rohan, de Silva, David F, Fischer, Elly M, Hol, Fred W, van Leeuwen, Andrew J, Lees
Publikováno v:
Journal of neurochemistry. 86(2)
Intracellular protein inclusions in Alzheimer's disease and progressive supranuclear palsy contain UBB+1, a variant ubiquitin. UBB+1 is able block the 26S proteasome in cell lines. Proteasome inhibition by drug action has previously been shown to ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd238bbbff53c157104aa1675fc0f195
https://pubmed.ncbi.nlm.nih.gov/12871580
https://pubmed.ncbi.nlm.nih.gov/12871580