Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Andrew D, White"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Students from groups historically excluded from STEM face heightened challenges to thriving and advancing in STEM. Prompting students to reflect on these challenges in light of their purpose can yield benefits by helping students see how the
Externí odkaz:
https://doaj.org/article/900269cb562646e392f266afe7e4056b
Autor:
Linda Voogd, Marjolein van Wolfswinkel, Iman Satti, Andrew D. White, Karin Dijkman, Anele Gela, Krista E. van Meijgaarden, Kees L. M. C. Franken, Julia L. Marshall, Tom H. M. Ottenhoff, Thomas J. Scriba, Helen McShane, Sally A. Sharpe, Frank A. W. Verreck, Simone A. Joosten
Publikováno v:
Vaccines, Vol 12, Iss 10, p 1129 (2024)
Background: Novel vaccines targeting the world’s deadliest pathogen Mycobacterium tuberculosis (Mtb) are urgently needed as the efficacy of the Bacillus Calmette–Guérin (BCG) vaccine in its current use is limited. HLA-E is a virtually monomorphi
Externí odkaz:
https://doaj.org/article/8b29e2c0143946339b940b075e6a6486
Autor:
Marco Polo Peralta Alvarez, Holly Jones, Hugo Redondo Azema, Chloe Davis, Andrew D. White, Charlotte Sarfas, Mike Dennis, Shuailin Li, Daniel Wright, Eugenia Puentes, Simon Kimuda, Sandra Belij-Rammerstorfer, Nacho Aguilo, Carlos Martin, Sally Sharpe, Helen McShane, Rachel Tanner
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionMycobacteria are known to exert a range of heterologous effects on the immune system. The mycobacteria-based Freund’s Complete Adjuvant is a potent non-specific stimulator of the immune response used in immunization protocols promoting
Externí odkaz:
https://doaj.org/article/cc2fbd2cbaf840388ae3efd7abd65b7d
Autor:
Jorge Medina, Andrew D. White
Publikováno v:
Journal of Cheminformatics, Vol 15, Iss 1, Pp 1-6 (2023)
Abstract Ultra-large chemical libraries are reaching 10s to 100s of billions of molecules. A challenge for these libraries is to efficiently check if a proposed molecule is present. Here we propose and study Bloom filters for testing if a molecule is
Externí odkaz:
https://doaj.org/article/1e8bcdcf40fe444e8fec45bf3d7237fe
Autor:
Andrew D. White, Andy C. Tran, Laura Sibley, Charlotte Sarfas, Alexandra L. Morrison, Steve Lawrence, Mike Dennis, Simon Clark, Sirine Zadi, Faye Lanni, Emma Rayner, Alastair Copland, Peter Hart, Gil Reynolds Diogo, Matthew J. Paul, Miyoung Kim, Fergus Gleeson, Francisco J. Salguero, Mahavir Singh, Matthias Stehr, Simon M. Cutting, Juan I. Basile, Martin E. Rottenberg, Ann Williams, Sally A. Sharpe, Rajko Reljic
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tuberculosis remains a major health threat globally and a more effective vaccine than the current Bacillus Calmette Guerin (BCG) is required, either to replace or boost it. The Spore-FP1 mucosal vaccine candidate is based on the fusion protein of Ag8
Externí odkaz:
https://doaj.org/article/5d6971450abd4bfbb64716fb58efad30
Autor:
Alexandra L. Morrison, Charlotte Sarfas, Laura Sibley, Jessica Williams, Adam Mabbutt, Mike J. Dennis, Steve Lawrence, Andrew D. White, Mark Bodman-Smith, Sally A. Sharpe
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1604 (2023)
Intravenously (IV) delivered BCG provides superior tuberculosis (TB) protection compared with the intradermal (ID) route in non-human primates (NHPs). We examined how γδ T cell responses changed in vivo after IV BCG vaccination of NHPs, and whether
Externí odkaz:
https://doaj.org/article/8cdbb2b4d36443c98f5fbd9003c1ea1c
Autor:
Teresa Lambe, Alexandra J. Spencer, Kelly M. Thomas, Karen E. Gooch, Stephen Thomas, Andrew D. White, Holly E. Humphries, Daniel Wright, Sandra Belij-Rammerstorfer, Nazia Thakur, Carina Conceicao, Robert Watson, Leonie Alden, Lauren Allen, Marilyn Aram, Kevin R. Bewley, Emily Brunt, Phillip Brown, Breeze E. Cavell, Rebecca Cobb, Susan A. Fotheringham, Ciaran Gilbride, Debbie J. Harris, Catherine M. K. Ho, Laura Hunter, Chelsea L. Kennard, Stephanie Leung, Vanessa Lucas, Didier Ngabo, Kathryn A. Ryan, Hannah Sharpe, Charlotte Sarfas, Laura Sibley, Gillian S. Slack, Marta Ulaszewska, Nadina Wand, Nathan R. Wiblin, Fergus V. Gleeson, Dalan Bailey, Sally Sharpe, Sue Charlton, Francisco J. Salguero, Miles W. Carroll, Sarah C. Gilbert
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induce
Externí odkaz:
https://doaj.org/article/9f8c33e0c50a4a85acb2b5617681d0f4
Autor:
Laura Sibley, Andrew D. White, Karen E. Gooch, Lisa M. Stevens, Rachel Tanner, Ashley Jacobs, Owen Daykin-Pont, Fergus Gleeson, Anthony McIntyre, Randall Basaraba, Simon Clark, Graham Hall, Geoff Pearson, Emma Rayner, Helen McShane, Ann Williams, Mike Dennis, Philip D. Marsh, Sally Sharpe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three
Externí odkaz:
https://doaj.org/article/012f7b94a99f4b9a8b55500c6bbff3f8
Autor:
Laura Sibley, Owen Daykin-Pont, Charlotte Sarfas, Jordan Pascoe, Andrew D. White, Sally Sharpe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Rhesus (Macaca mulatta) and cynomolgus (Macaca fasicularis) macaques of distinct genetic origin are understood to vary in susceptibility to Mycobacterium tuberculosis, and therefore differences in their immune systems may account for the dif
Externí odkaz:
https://doaj.org/article/0b0b6b8a99334168a66892271de4fa7d
Autor:
Francisco J. Salguero, Andrew D. White, Gillian S. Slack, Susan A. Fotheringham, Kevin R. Bewley, Karen E. Gooch, Stephanie Longet, Holly E. Humphries, Robert J. Watson, Laura Hunter, Kathryn A. Ryan, Yper Hall, Laura Sibley, Charlotte Sarfas, Lauren Allen, Marilyn Aram, Emily Brunt, Phillip Brown, Karen R. Buttigieg, Breeze E. Cavell, Rebecca Cobb, Naomi S. Coombes, Alistair Darby, Owen Daykin-Pont, Michael J. Elmore, Isabel Garcia-Dorival, Konstantinos Gkolfinos, Kerry J. Godwin, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas Hender, Catherine M. K. Ho, Chelsea L. Kennard, Daniel Knott, Stephanie Leung, Vanessa Lucas, Adam Mabbutt, Alexandra L. Morrison, Charlotte Nelson, Didier Ngabo, Jemma Paterson, Elizabeth J. Penn, Steve Pullan, Irene Taylor, Tom Tipton, Stephen Thomas, Julia A. Tree, Carrie Turner, Edith Vamos, Nadina Wand, Nathan R. Wiblin, Sue Charlton, Xiaofeng Dong, Bassam Hallis, Geoffrey Pearson, Emma L. Rayner, Andrew G. Nicholson, Simon G. Funnell, Julian A. Hiscox, Mike J. Dennis, Fergus V. Gleeson, Sally Sharpe, Miles W. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung h
Externí odkaz:
https://doaj.org/article/87631802f4e34ba091e1f0a793783536