Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Andrew D, Westwell"'
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract In the early 1990’s a group of unrelated genes were identified from the sites of recurring translocations in B-cell lymphomas. Despite sharing the nomenclature ‘Bcl’, and an association with blood-borne cancer, these genes have unrelat
Externí odkaz:
https://doaj.org/article/6707128c3c574f31b5771f3313c2724c
Autor:
Alessandra Crusco, Rafael Baptista, Sumana Bhowmick, Manfred Beckmann, Luis A. J. Mur, Andrew D. Westwell, Karl F. Hoffmann
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
A library of 14 minimally cytotoxic diterpenoid-like compounds (CC50 > 70 μM on HepG2 human liver cells) was screened against Mycobacterium smegmatis, Staphylococcus aureus, and Escherichia coli to determine antimicrobial activity. Some compounds wi
Externí odkaz:
https://doaj.org/article/6e463851811342a1846485dc3f794f6c
Autor:
Malathy P.V. Shekhar, Andrew D. Westwell, Hend Kothayer, Matteo Morelli, Vitaly Balan, Pratima Nangia-Makker, Ghali Brahemi, Matthew A. Sanders
PDF file - 109K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a4a479a418ff0311deedffbc0f823f
https://doi.org/10.1158/1535-7163.22497676.v1
https://doi.org/10.1158/1535-7163.22497676.v1
Publikováno v:
Molecules, Vol 26, Iss 1, p 56 (2020)
The androgen receptor (AR) is a pivotal target for the treatment of prostate cancer (PC) even when the disease progresses toward androgen-independent or castration-resistant forms. In this study, a series of 15 bicalutamide analogues (sulfide, deshyd
Externí odkaz:
https://doaj.org/article/824e6a0425e3490d9aac88a3a0f45e21
Publikováno v:
Molecules, Vol 25, Iss 15, p 3488 (2020)
Focal adhesion kinase (FAK) is a tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. In cancer cells, FAK promotes the progression and metastasis of tumours. In this study, we used structure-based virtual scre
Externí odkaz:
https://doaj.org/article/01751d9247db4a43bf5992c4e26c0647
Autor:
Alessandra Cavaliere, Katrin C. Probst, Stephen J. Paisey, Christopher Marshall, Abdul K. H. Dheere, Franklin Aigbirhio, Christopher McGuigan, Andrew D. Westwell
Publikováno v:
Molecules, Vol 25, Iss 3, p 704 (2020)
Phosphoramidate pro-nucleotides (ProTides) have revolutionized the field of anti-viral and anti-cancer nucleoside therapy, overcoming the major limitations of nucleoside therapies and achieving clinical and commercial success. Despite the translation
Externí odkaz:
https://doaj.org/article/2e11479901e84c4b8e768815c561ddf1
Publikováno v:
Molecules, Vol 24, Iss 7, p 1274 (2019)
The Bcl-2 protein has been studied as an anticancer drug target in recent years, due to its gatekeeper role in resisting programmed cancer cell death (apoptosis), and the design of BH3 domain mimetics has led to the clinical approval of Venetoclax (A
Externí odkaz:
https://doaj.org/article/5b45fe5be63546acaf769bcb3d868c40
Autor:
Charlotte Young, Lucy C. Fairclough, Andrew D. Westwell, Kerry Roberts, Kate Davies, Thomas Tozer, Stephanie E A Burnell, Paddy Tighe, Tara Rees, Amanda Jackson, B. Paul Morgan, Awen Gallimore, Martin J. Scurr, Michelle Somerville, Mererid Evans, Andrew James Godkin, George Lippiatt, Wioleta M. Zelek, Mark R. Wills, Helen Lawton, Lorenzo Capitani
Publikováno v:
Immunology
Accurate assessment of SARS‐CoV‐2 immunity is critical in evaluating vaccine efficacy and devising public health policies. Whilst the exact nature of effective immunity remains incompletely defined, SARS‐CoV‐2‐specific T‐cell responses ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65d98df614d6784a18360ac8e997abea
http://europepmc.org/articles/PMC8653009
http://europepmc.org/articles/PMC8653009
Autor:
Sarra B. Shakartalla, Rania Hamdy, Sameh S. M. Soliman, Zainab M. Al Shareef, Mohamed El-Sadek, Alshaimaa M. Hamoda, Arwyn Tomos Jones, Andrew D. Westwell
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12272, p 12272 (2021)
Volume 22
Issue 22
International Journal of Molecular Sciences, Vol 22, Iss 12272, p 12272 (2021)
A series of 3-(6-substituted phenyl-[1,2,4]-triazolo[3,4-b]-[1,3,4]-thiadiazol-3-yl)-1H-indoles (5a–l) were designed, synthesized and evaluated for anti-apoptotic Bcl-2-inhibitory activity. Synthesis of the target compounds was readily accomplished
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8961edaf459221a57dbb59ffc728cbba
http://europepmc.org/articles/PMC8621373
http://europepmc.org/articles/PMC8621373
Publikováno v:
Future Medicinal Chemistry. 11:161-164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3f5a9e90b9bccd8f6ab6e887fbfe452
https://doi.org/10.4155/fmc-2018-0447
https://doi.org/10.4155/fmc-2018-0447