Zobrazeno 1 - 10 of 202 pro vyhledávání: '"Andrew D, Mesecar"'
1
Akademický článek
Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
Autor: Sucharita Bose, C. Nicklaus Steussy, Daneli López-Pérez, Tim Schmidt, Samadhi C. Kulathunga, Mohamed N. Seleem, Mark Lipton, Andrew D. Mesecar, Victor W. Rodwell, Cynthia V. Stauffacher
Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
High-throughput in vitro screening and crystal structures identify a non-statin inhibitor of HMG-CoA reductase for novel antibacterial drug design.
Externí odkaz: https://doaj.org/article/ff33f7666d8d44099aa084b1ad4f545f
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2
Akademický článek
SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late‐onset Alzheimer's disease
Autor: Cynthia D. Jesudason, Emily R. Mason, Shaoyou Chu, Adrian L. Oblak, June Javens‐Wolfe, Mustapha Moussaif, Greg Durst, Philip Hipskind, Daniel E. Beck, Jiajun Dong, Ovini Amarasinghe, Zhong‐Yin Zhang, Adam K. Hamdani, Kratika Singhal, Andrew D. Mesecar, Sarah Souza, Marlene Jacobson, Jerry Di Salvo, Disha M. Soni, Murugesh Kandasamy, Andrea R. Masters, Sara K Quinney, Suzanne Doolen, Hasi Huhe, Stacey J. Sukoff Rizzo, Bruce T. Lamb, Alan D. Palkowitz, Timothy I. Richardson
Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 9, Iss 4, Pp n/a-n/a (2023)
Abstract INTRODUCTION The risk of developing Alzheimer's disease is associated with genes involved in microglial function. Inositol polyphosphate‐5‐phosphatase (INPP5D), which encodes Src homology 2 (SH2) domain–containing inositol polyphosphat
Externí odkaz: https://doaj.org/article/4d6f6a10135b4cdbb5e5fc4dd51947a7
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4
Akademický článek
A small molecule compound with an indole moiety inhibits the main protease of SARS-CoV-2 and blocks virus replication
Autor: Shin-ichiro Hattori, Nobuyo Higashi-Kuwata, Hironori Hayashi, Srinivasa Rao Allu, Jakka Raghavaiah, Haydar Bulut, Debananda Das, Brandon J. Anson, Emma K. Lendy, Yuki Takamatsu, Nobutoki Takamune, Naoki Kishimoto, Kazutaka Murayama, Kazuya Hasegawa, Mi Li, David A. Davis, Eiichi N. Kodama, Robert Yarchoan, Alexander Wlodawer, Shogo Misumi, Andrew D. Mesecar, Arun K. Ghosh, Hiroaki Mitsuya
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Here, using in vitro assays and structural analysis, the authors characterize the anti-SARS-CoV-2 properties of two small molcules, showing these to bind and target the virus main protease (Mpro), and to exhibit a synergistic antiviral effect when co
Externí odkaz: https://doaj.org/article/86d3e81f7e794c15baedd9ad9a968412
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5
Akademický článek
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors
Autor: Arun K. Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy, Connie Bonham, Devika Sirohi, Carlos A. Brito-Sierra, Shin-ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D. Mesecar
Publikováno v: Molecules, Vol 26, Iss 19, p 5782 (2021)
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synth
Externí odkaz: https://doaj.org/article/f42c479ac437463dac472853373f2de5
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