Zobrazeno 1 - 10
of 548
pro vyhledávání: '"Andrew D, Badley"'
Autor:
Ravindra Ganesh, Siddhant Yadav, Ryan T. Hurt, Michael R. Mueller, Christopher A. Aakre, Elizabeth A. Gilman, Stephanie L. Grach, Joshua Overgaard, Melissa R. Snyder, Nerissa M. Collins, Ivana T. Croghan, Andrew D. Badley, Raymund R. Razonable, Bradley R. Salonen
Publikováno v:
Journal of Primary Care & Community Health, Vol 15 (2024)
Background: Over 30% of patients with COVID-19 have persistent symptoms that last beyond 30 days and referred to as Long COVID. Long COVID has been associated with a persistent elevation in peripheral cytokines including interleukin-6, interleukin-1
Externí odkaz:
https://doaj.org/article/c8b19f3bdac2437dac9b4c228d3ae0b8
Autor:
Elizabeth Ann L Enninga, Huy Quang Quach, Jin Sung Jang, Maria Cristina Miranda de Araujo Correia, Yaroslav Fedyshyn, Bohdana Fedyshyn, Maureen Lemens, Dawn Littlefield, Supriya Behl, Elise Sintim-Aboagye, Maria C Mejia Plazas, Maria C Cardenas, Shree Chakraborty, Satoko Yamaoka, Hideki Ebihara, Akhilesh Pandey, Hu Li, Andrew D Badley, Erica L Johnson, Jie Sun, Andrew P Norgan, Regan N Theiler, Rana Chakraborty
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011990 (2024)
BackgroundHofbauer cells (HBCs) and cytotrophoblasts (CTBs) are major cell populations in placenta. The indirect impact of maternal SARS-CoV-2 disease on these cells that are not directly infected has not been extensively studied. Herein, we profiled
Externí odkaz:
https://doaj.org/article/12c1ccaa727f4b4ba397eb3630dd85bf
Autor:
A. J. Venkatakrishnan, Praveen Anand, Patrick J. Lenehan, Pritha Ghosh, Rohit Suratekar, Eli Silvert, Colin Pawlowski, Abhishek Siroha, Dibyendu Roy Chowdhury, John C. O’Horo, Joseph D. Yao, Bobbi S. Pritt, Andrew P. Norgan, Ryan T. Hurt, Andrew D. Badley, John Halamka, Venky Soundararajan
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The emergence of highly transmissible SARS-CoV-2 variants and vaccine breakthrough infections globally mandated the characterization of the immuno-evasive features of SARS-CoV-2. Here, we systematically analyzed 2.13 million SARS-CoV-2 genom
Externí odkaz:
https://doaj.org/article/fba33ff5aa224b2f947ad65933a846dd
Autor:
Xiaosheng Wu, Michelle K. Manske, Gordon J. Ruan, Taylor L. Witter, Kevin E. Nowakowski, Jithma P. Abeykoon, Xinyi Tang, Yue Yu, Kimberly A. Gwin, Annie Wu, Vanessa Taupin, Vaishali Bhardwaj, Jonas Paludo, Surendra Dasari, Haidong Dong, Stephen M. Ansell, Andrew D. Badley, Matthew J. Schellenberg, Thomas E. Witzig
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106929- (2023)
Summary: Despite extensive research, the specific factor associated with SARS-CoV-2 infection that mediates the life-threatening inflammatory cytokine response in patients with severe COVID-19 remains unidentified. Herein we demonstrate that the viru
Externí odkaz:
https://doaj.org/article/008c8e98333d4304b6e7fee69dec3a76
Autor:
Robert P Matson, BS, Michiel J M Niesen, PhD, Emily R Levy, MD, Derek N Opp, DO, Patrick J Lenehan, PhD, Greg Donadio, MA, John C O'Horo, ProfMD, A J Venkatakrishnan, PhD, Andrew D Badley, ProfMD, Venky Soundararajan, PhD
Publikováno v:
The Lancet: Digital Health, Vol 5, Iss 4, Pp e206-e216 (2023)
Summary: Background: The emergency use authorisation of BNT162b2 (tozinameran; Comirnaty, Pfizer–BioNTech) for children aged 5–17 years has resulted in rapid vaccination in the paediatric population. However, there are few studies of adverse even
Externí odkaz:
https://doaj.org/article/7a5fc9eade034d6dad7d93a8c05949a9
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
While modern HIV therapy can effectively suppress viral replication, the persistence of the latent reservoir posits the greatest hurdle to complete cure. The “shock and kill” strategy is under investigation for HIV therapy, aiming to reactivate l
Externí odkaz:
https://doaj.org/article/deca31baa39d4920973cb0b049d66cbd
Mapping each pre-existing condition’s association to short-term and long-term COVID-19 complications
Autor:
A. J. Venkatakrishnan, Colin Pawlowski, David Zemmour, Travis Hughes, Akash Anand, Gabriela Berner, Nikhil Kayal, Arjun Puranik, Ian Conrad, Sairam Bade, Rakesh Barve, Purushottam Sinha, John C. O‘Horo, Andrew D. Badley, John Halamka, Venky Soundararajan
Publikováno v:
npj Digital Medicine, Vol 4, Iss 1, Pp 1-11 (2021)
Abstract Understanding the relationships between pre-existing conditions and complications of COVID-19 infection is critical to identifying which patients will develop severe disease. Here, we leverage ~1.1 million clinical notes from 1803 hospitaliz
Externí odkaz:
https://doaj.org/article/5d3be4022eee45a2a9e665e11457f771
Autor:
Zachary A. Yetmar, MD, Douglas W. Challener, MD, Imad M. Tleyjeh, MD, MSc, M. Rizwan Sohail, MD, James R. Cerhan, MD, PhD, Andrew D. Badley, MD, John C. O’Horo, MD, MPH
Publikováno v:
Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 2, Pp 442-446 (2021)
Objective: To determine the association between chronic statin use and mortality in patients hospitalized with coronavirus disease 2019 (COVID-19). Patients and Methods: We identified a retrospective cohort of patients requiring admission at the Mayo
Externí odkaz:
https://doaj.org/article/96aa9985020e4a23afd7599c72d8ea7b
Autor:
Samir Awasthi, Tyler Wagner, A. J. Venkatakrishnan, Arjun Puranik, Matthew Hurchik, Vineet Agarwal, Ian Conrad, Christian Kirkup, Raman Arunachalam, John O’Horo, Walter Kremers, Rahul Kashyap, William Morice, John Halamka, Amy W. Williams, William A. Faubion, Andrew D. Badley, Gregory J. Gores, Venky Soundararajan
Publikováno v:
Cell Death Discovery, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Intensive care unit (ICU) admissions and mortality in severe COVID-19 patients are driven by “cytokine storms” and acute respiratory distress syndrome (ARDS). Interim clinical trial results suggest that the corticosteroid dexamethasone d
Externí odkaz:
https://doaj.org/article/21d3d722d5694b8e826ba15f02943128
Autor:
Colin Pawlowski, Arjun Puranik, Hari Bandi, A. J. Venkatakrishnan, Vineet Agarwal, Richard Kennedy, John C. O’Horo, Gregory J. Gores, Amy W. Williams, John Halamka, Andrew D. Badley, Venky Soundararajan
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Abstract Clinical studies are ongoing to assess whether existing vaccines may afford protection against SARS-CoV-2 infection through trained immunity. In this exploratory study, we analyze immunization records from 137,037 individuals who received SA
Externí odkaz:
https://doaj.org/article/fd67bc36356140aaa170bb2c2ae1d4bb