Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Andrew Craxton"'
Autor:
Niall A. Buckley, Andrew Craxton, Xiao-Ming Sun, Emanuele Panatta, Lucia Giraldez Pinon, Sina Beier, Lajos Kalmar, Jaime Llodrá, Nobuhiro Morone, Ivano Amelio, Gerry Melino, L. Miguel Martins, Marion MacFarlane
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-13 (2024)
Abstract Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics. TAp73 regulates the express
Externí odkaz:
https://doaj.org/article/b7ed34c281d6442daa8f3233d2879a64
Autor:
Juan Carlos Yam-Puc, Zhaleh Hosseini, Emily C. Horner, Pehuén Pereyra Gerber, Nonantzin Beristain-Covarrubias, Robert Hughes, Aleksei Lulla, Maria Rust, Rebecca Boston, Magda Ali, Katrin Fischer, Edward Simmons-Rosello, Martin O’Reilly, Harry Robson, Lucy H. Booth, Lakmini Kahanawita, Andrea Correa-Noguera, David Favara, Lourdes Ceron-Gutierrez, Baerbel Keller, Andrew Craxton, Georgina S. F. Anderson, Xiao-Ming Sun, Anne Elmer, Caroline Saunders, Areti Bermperi, Sherly Jose, Nathalie Kingston, Thomas E. Mulroney, Lucia P. G. Piñon, CITIID-NIHR COVID−19 BioResource Collaboration, Michael A. Chapman, Sofia Grigoriadou, Marion MacFarlane, Anne E. Willis, Kiran R. Patil, Sarah Spencer, Emily Staples, Klaus Warnatz, Matthew S. Buckland, Florian Hollfelder, Marko Hyvönen, Rainer Döffinger, Christine Parkinson, Sara Lear, Nicholas J. Matheson, James E. D. Thaventhiran
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Age-associated B cells (ABC) accumulate with age and in individuals with different immunological disorders, including cancer patients treated with immune checkpoint blockade and those with inborn errors of immunity. Here, we investigate whet
Externí odkaz:
https://doaj.org/article/6ba7520f8a864e5db48cb0eaab277223
Autor:
Tatyana Chernova, Stefano Grosso, Xiao-Ming Sun, Angela Rubio Tenor, Joaquin Zacarias Cabeza, Andrew Craxton, Emily L. Self, Apostolos Nakas, Kelvin Cain, Marion MacFarlane, Anne E. Willis
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12469 (2022)
Malignant mesothelioma is an aggressive tumour of the pleura (MPM) or peritoneum with a clinical presentation at an advanced stage of the disease. Current therapies only marginally improve survival and there is an urgent need to identify new treatmen
Externí odkaz:
https://doaj.org/article/c321fb87e857484aac096bc155dbd1aa
Autor:
Andrew Craxton, Deeksha Munnur, Rebekah Jukes-Jones, George Skalka, Claudia Langlais, Kelvin Cain, Michal Malewicz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
PAXX functions as part of the nonhomologous end-joining pathway to repair double-strand DNA breaks. Here the authors show PAXX and its paralogs interact with polymerase lambda to promote joining of incompatible ends.
Externí odkaz:
https://doaj.org/article/9c0730c851de40b5b3372bd7dc7822b1
Autor:
Xiao-Ming Sun, Gareth J Miles, Ian R Powley, Andrew Craxton, Sarah Galavotti, Tatyana Chernova, Alan Dawson, Apostolos Nakas, Anne E Willis, Kelvin Cain, Marion MacFarlane
Malignant pleural mesothelioma (MPM) is an aggressive malignancy linked to asbestos exposure and highly resistant to chemotherapy, potentially due to upregulated expression of the pro-survival proteins, BCL2/BCL-XL/MCL-1. Using clinically-relevant mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98277997b6932d4c9836a4416bc5604c
https://doi.org/10.1101/2023.03.31.534530
https://doi.org/10.1101/2023.03.31.534530
Autor:
Niall Buckley, Andrew Craxton, Xiao-Ming Sun, Emanuele Panatta, Lucia Pinon, Jaime Llodrá, Nobuhiro Morone, Ivano Amelio, Gerry Melino, L. Miguel Martins, Marion MacFarlane
Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics. TAp73 regulates the expression of Op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83a9974f68888d8dce0c53f5d30dd501
https://doi.org/10.1101/2023.03.23.533672
https://doi.org/10.1101/2023.03.23.533672
Autor:
Kristel Martinez Lagunas, Deniz Pinar Savcigil, Matea Zrilic, Carlos Carvajal Fraile, Andrew Craxton, Emily Self, Iratxe Uranga-Murillo, Diego de Miguel, Maykel Arias, Sebastian Willenborg, Michael Piekarek, Marie Christine Albert, Kalvin Nugraha, Ina Lisewski, Erika Janakova, Natalia Igual, Wulf Tonnus, Ximena Hildebrandt, Mohammed Ibrahim, Marlies Ballegeer, Xavier Saelens, Andrew Kueh, Pascal Meier, Andreas Linkermann, Julian Pardo, Sabine Eming, Henning Walczak, Marion MacFarlane, Nieves Peltzer, Alessandro Annibaldi
Cell death coordinates repair programs following pathogen attack and tissue injury. However, aberrant cell death can interfere with such programs and cause organ failure. cFLIP is a crucial regulator of cell death and a substrate of Caspase-8. Yet, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8bb7e2368b9389a805851fe5ebd29e9
https://doi.org/10.1101/2022.12.15.520548
https://doi.org/10.1101/2022.12.15.520548
Autor:
Joaquin Zacarias-Cabeza, Tatyana Chernova, Andrew Craxton, Xiao-Ming Sun, Sara Galavotti, Sina Beier, Emily L Self, Peter Greaves, Craig A Poland, Shuji Tsuruoka, Dale W Porter, Anne E Willis, Marion MacFarlane
Publikováno v:
Annals of Work Exposures and Health. 67:i76-i77
Engineered carbon nanotubes (CNT) are currently used in many industrial products. Multi-walled carbon nanotubes (MWCNT) exhibit unique physicochemical properties and due to their low density and small size are easily aerosolized, making workplace exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::182499a49370df916fe0d2a8fae032f2
https://doi.org/10.1093/annweh/wxac087.184
https://doi.org/10.1093/annweh/wxac087.184
Autor:
Joaquin Zacarias Cabeza, Tatyana Chernova, Xiao-Ming Sun, Andrew Craxton, Sara Galavotti, Pierre Cauchy, Sina Beier, Ruth Spriggs, Fiona A Murphy, Peter Greaves, Craig A Poland, Anne E Willis, Marion MacFarlane
Publikováno v:
Annals of Work Exposures and Health. 67:i61-i61
Exposure to asbestos causes pathological changes in the pleural cavity, including malignant mesothelioma (MPM). Length-dependent retention of asbestos fibres in the pleural cavity is crucial for disease development. Chronic inflammation induced by bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf5cf9e04def0e31c3235b86af72ea08
https://doi.org/10.1093/annweh/wxac087.147
https://doi.org/10.1093/annweh/wxac087.147
Publikováno v:
European Journal of Immunology. 37:2715-2722
BH3-only Bcl-2 homologs are key regulators of the intrinsic apoptotic pathway. In particular, Bim, is critical for mediating apoptosis of hematopoietic cells including B cells. While studies using Bcl-2 Tg mice have defined an important role for Bcl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04bc5b1d0296ba7cb7d4d7ae62cf7d28
https://doi.org/10.1002/eji.200737327
https://doi.org/10.1002/eji.200737327