Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Andrew Collick"'
Publikováno v:
Human Molecular Genetics. 6:1565-1571
Human minisatellite MS32 (D1S8) shows instability both in the germline and, at much lower levels, in somatic DNA. To investigate factors that influence somatic and germline mutation, large cosmid-based constructs containing MS32 were introduced into
Autor:
Andrew Collick, Wolf Reik, J. Drew, Alec J. Jeffreys, Philippe Bois, J. Penberth, Jeni Luckett, F. Scaerou
Publikováno v:
Scopus-Elsevier
Various sequences in the mammalian genomes are unstable. One class of sequence arrangement is long inverted repeats, which are known to be unstable in bacteria and yeast. While in mammals some evidence suggests that short inverted repeats (
Publikováno v:
Genome Research. 4:71-75
Vectorette PCR permits the specific amplification of DNA segments flanking a known DNA sequence. It enables the application of the PCR where sequence information is only available for one primer site. We now show that vectorette PCR can be used for t
Autor:
Sheila C. Barton, Andrew Collick, M. A. Surani, Alec J. Jeffreys, Michael L. Norris, Maxine J. Allen
Publikováno v:
Nucleic Acids Research. 22:2976-2981
The human hypervariable minisatellite MS32 has a well characterised internal repeat unit array and high mutation rates have been observed at this locus. Analysis of MS32 mutants has shown that male germline mutations are polarised to one end of the a
Publikováno v:
Proceedings of the Royal Society of London. Series B: Biological Sciences. 245:235-245
Hypervariability at minisatellite loci is maintained by spontaneous mutation to new-length alleles. At the most variable loci, mutation rate is directly measurable by pedigree analysis. The mouse minisatellite locus Ms6-hm has a germline mutation rat
Publikováno v:
Nucleic Acids Research. 19:6399-6404
Msbp-1 is a minisatellite-specific DNA-binding protein. Using synthetic binding substrates, we now show that Msbp-1 binds not to double-stranded DNA, but exclusively to single-stranded DNA. Binding is specific to the guanine-rich strand of the minisa
Publikováno v:
Genomics. 65(2)
The most variable human minisatellites show extreme germline instability dominated by complex intra-allelic rearrangements plus a lower frequency of inter-allelic transfers of repeat units. In contrast, little is known about somatic instability at su
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781489900913
Evermore sophisticated tests are need to study germline toxicology. The gene conversion-based systems developed in Leicester and in the USA are steps in the right direction, but a lot of validation both in vivo and in vitro is required. Transgenic te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33fc066344c2d725de7a09e553d18a30
https://doi.org/10.1007/978-1-4899-0089-0_14
https://doi.org/10.1007/978-1-4899-0089-0_14
Autor:
Yuri E. Dubrova, David L. Neil, John Murray, Jane Yardley, Jérǒme Buard, Philippe Bois, Caroline R. H. Hollies, Rita Neumann, Alec J. Jeffreys, Andrew Collick, Celia A. May, Keiji Tamaki, John D.H. Stead
Publikováno v:
Electrophoresis. 18(9)
Minisatellites provide not only the basis for DNA fingerprinting and DNA profiling but also extremely informative systems for analysing processes of tandem repeat turnover in the human genome. Minisatellite instability appears to involve distinct mut
Autor:
Mark A. Jobling, Neale Fretwell, Tara Guram, Yuri E. Dubrova, Rita Neumann, Andrew Collick, David L. Neil, Maxine J. Allen, Alec J. Jeffreys, Celia A. May, John A.L. Armour
Publikováno v:
Electrophoresis. 16(9)
Minisatellites provide one of the most experimentally tractable systems for studying tandem repeat instability in man. Analysis of mutation processes has been greatly aided by the development of single molecule methods for recovering de novo mutants,