Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Andrew Churchyard"'
Autor:
Govinda R. Poudel, Julie C. Stout, Juan F. Domínguez D., Andrew Churchyard, Phyllis Chua, Gary F. Egan, Nellie Georgiou-Karistianis
Publikováno v:
Neurobiology of Disease, Vol 74, Iss , Pp 406-412 (2015)
Objective: To quantify 18-month changes in white matter microstructure in premanifest (pre-HD) and symptomatic Huntington's disease (symp-HD). To investigate baseline clinical, cognitive and motor symptoms that are predictive of white matter microstr
Externí odkaz:
https://doaj.org/article/907075d0f5754360b237b3fe3f321a3b
Autor:
Govinda R. Poudel, Julie C. Stout, Juan F. Domínguez D, Louisa Salmon, Andrew Churchyard, Phyllis Chua, Nellie Georgiou-Karistianis, Gary F. Egan
Publikováno v:
Neurobiology of Disease, Vol 65, Iss , Pp 180-187 (2014)
Objective: To investigate structural connectivity and the relationship between axonal microstructure and clinical, cognitive, and motor functions in premanifest (pre-HD) and symptomatic (symp-HD) Huntington's disease. Method: Diffusion tensor imaging
Externí odkaz:
https://doaj.org/article/3258e4f795054a988286e6a11627dffa
Autor:
Jessica Despard, Anne-Marie Ternes, Bleydy Dimech-Betancourt, Govinda Poudel, Andrew Churchyard, Nellie Georgiou-Karistianis
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0133709 (2015)
Voluntary motor deficits are a common feature in Huntington's disease (HD), characterised by movement slowing and performance inaccuracies. This deficit may be exacerbated when visual cues are restricted.To characterize the upper limb motor profile i
Externí odkaz:
https://doaj.org/article/6d6e1fe217344440940059097a8f63b0
Autor:
Lauren M Turner, Rodney J Croft, Andrew Churchyard, Jeffrey C L Looi, Deborah Apthorp, Nellie Georgiou-Karistianis
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138563 (2015)
Huntington's disease (HD) causes progressive motor dysfunction through characteristic atrophy. Changes to neural structure begin in premanifest stages yet individuals are able to maintain a high degree of function, suggesting involvement of supportiv
Externí odkaz:
https://doaj.org/article/7c58c8665df24538ac0d57326330aee6
Autor:
Sanaz Gabery, Nellie Georgiou-Karistianis, Sofia Hult Lundh, Rachel Y Cheong, Andrew Churchyard, Phyllis Chua, Julie C Stout, Gary F Egan, Deniz Kirik, Åsa Petersén
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117593 (2015)
Huntington disease (HD) is a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances, sleep problems and metabolic dysfunction are part of the disease man
Externí odkaz:
https://doaj.org/article/c3fb7b77c8ad4104b2890bb64f84d860
Autor:
Juan F Domínguez D, Gary F Egan, Marcus A Gray, Govinda R Poudel, Andrew Churchyard, Phyllis Chua, Julie C Stout, Nellie Georgiou-Karistianis
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74131 (2013)
IMAGE-HD is an Australian based multi-modal longitudinal magnetic resonance imaging (MRI) study in premanifest and early symptomatic Huntington's disease (pre-HD and symp-HD, respectively). In this investigation we sought to determine the sensitivity
Externí odkaz:
https://doaj.org/article/6c9c67143dc7415fb4eaa0bb7583e423
Aggression in Huntington's Disease: A Systematic Review of Rates of Aggression and Treatment Methods
© 2014-IOS Press and the authors. Aggression is commonly reported in individuals with Huntington's disease (HD). While correlating factors for aggression are often speculated about, features that are associated with, and contribute to, aggression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b501b5a09b8825bcca7126ac19e823d5
Autor:
Nellie Georgiou-Karistianis, Gary F. Egan, Phyllis Chua, Julie C. Stout, Govinda Poudel, Andrew Churchyard, Juan F Dominguez
Publikováno v:
British Journal of Psychiatry. 208:571-578
BackgroundThe discovery of potential disease-modifying therapies in a neurodegenerative condition like Huntington's disease depends on the availability of sensitive biomarkers that reflect decline across disease stages and that are functionally and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87b8fcefe7c838b978bf98710750f392
https://doi.org/10.1192/bjp.bp.114.156588
https://doi.org/10.1192/bjp.bp.114.156588
Autor:
April L. Philpott, Tarrant D.R. Cummins, Neil W. Bailey, Paul B. Fitzgerald, Andrew Churchyard, Nellie Georgiou-Karistianis
Publikováno v:
Behavioural Brain Research. 296:311-317
Although progress has been made towards understanding the gross cortical and subcortical pathology of Huntington's disease (HD), there remains little understanding of the progressive pathophysiological changes that occur in the brain circuits underly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83fc69794def1b92215c8de90089a5c2
https://doi.org/10.1016/j.bbr.2015.09.030
https://doi.org/10.1016/j.bbr.2015.09.030
Publikováno v:
Journal of Neurology. 262:268-276
Huntington's disease (HD) is associated with impairments in dual-task performance. Despite that, only a few studies have investigated dual-tasking in HD. We examined dual-task performance in 15 participants in the early stages of HD and 15 healthy co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b7f097050640846ed2256ff33ff87e
https://doi.org/10.1007/s00415-014-7563-9
https://doi.org/10.1007/s00415-014-7563-9