Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andrew Chi-Yuen Chu"'
Autor:
Yuen Yuen Ma, Yan Shao, Xiao Bing Liu, Andrew Chi-Yuen Chu, Chang Chun Ling, Chang Xian Li, Kwan Man, Kevin Tak-Pan Ng, Sheung Tat Fan, Chung Mau Lo
Publikováno v:
Cancer Letters. 355:264-272
Human hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide with a poor prognosis of limited survival. The role of regulatory B cell (Breg), a new important B cell subset, in HCC progression remains unclear. We firstly found that t
Autor:
Pak-Leung Ho, Andrew Chi-Yuen Chu, Koon-Ho Chan, Rui Zhang, J.S.C. Kwan, Jessica Wing-Man Ho, Vivian Yawei Guo
Publikováno v:
Journal of Neuroimmunology. 245:32-38
Background Neuromyelitis optica (NMO) is a central nervous system inflammatory demyelinating disorder. Up to 90% of patients are seropositive for aquaporin-4 autoantibodies (AQP4 Ab). The pathogenetic mechanisms underlying clinical onset and relapse
Autor:
Andrew Chi-Yuen Chu, Jessica Wing-Man Ho, Mhw Kung, J.S.C. Kwan, Wei-Yi Zhang, Shu-Leong Ho, Koon-Ho Chan, W.H. Chui, Pak-Leung Ho
Publikováno v:
Journal of Neuroimmunology. 227:178-184
Background Neuromyelitis optica (NMO) is a serious idiopathic inflammatory demyelinating disorder characterized by acute transverse myelitis and optic neuritis. A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody ta
Autor:
Philip Wing-Lok Ho, Shu-Leong Ho, Andrew Chi-Yuen Chu, Xuan Ge, Koon-Ho Chan, Ken Hon-Hung Kwok, Wei-Yi Zhang, David B. Ramsden, Jessica Wing-Man Ho, Hui-Fang Liu
Publikováno v:
Neurotoxicity Research
Mitochondrial dysfunction is involved in the pathogenesis of neurodegenerative diseases, including Parkinson's disease (PD). Uncoupling proteins (UCPs) delink ATP production from biofuel oxidation in mitochondria to reduce oxidative stress. UCP2 is e
Autor:
David B. Ramsden, Koon-Ho Chan, Shu-Leong Ho, Ken H. H. Kwok, Michelle Hiu-Wai Kung, Windsor Mak, Gardian C. Y. Fong, You-Qiang Song, TS Cheng, Raymond T.F. Cheung, Andrew Chi-Yuen Chu, Philip Wing-Lok Ho
Publikováno v:
Amyotrophic Lateral Sclerosis. 7:142-149
About 10% of amyotrophic lateral sclerosis (ALS) cases are familial. We identified a five-generation Chinese family with autosomal dominant familial ALS (FALS). We performed a detailed family study, clinical and electromyographic validation, and SOD1
Autor:
David Yiu Leung Chan, Shu-Leong Ho, David B. Ramsden, Jessica Wing-Man Ho, Michelle Hiu-Wai Kung, Ken Hon-Hung Kwok, Philip Wing-Lok Ho, Andrew Chi-Yuen Chu
Publikováno v:
Journal of Neuroscience Research. 81:261-268
Methyl-4-phenylpyridinium ion (MPP(+)), a specific dopaminergic neurotoxin, inhibits mitochondrial complex I activity, generates reactive oxygen species (ROS), reduces ATP production, and induces cell death. We explored changes in expression of uncou
Autor:
Kenji Kaneda, Kwan Man, John M. Luk, Yang Q Wang, Andrew Chi-Yuen Chu, Kazuo Ikeda, Sheung Tat Fan
Publikováno v:
Biochemical and Biophysical Research Communications. 317:358-362
Activated hepatic stellate cells (HSCs) produce cyclooxygenase-2 (COX-2) protein to induce vascular endothelial growth factor (VEGF) production that participates in angiogenesis in injured liver. To reveal the unknown regulatory mechanism, we used hy
Publikováno v:
American Journal of Transplantation. 4:196-209
This study aims to investigate the immunological status of small-for-size liver allografts and possible mechanism that contributes to the accelerated immune response in these allografts. Eight experimental groups were: whole isografts; 40% isografts;
Publikováno v:
Life Sciences. 67:2117-2124
The development of multiple drug resistance in tumor cells is a significant problem in cancer therapy. In human, one of the reasons causing the resistance is due to the overexpression of the mdr1 gene product, P-glycoprotein. In our study, we had dev
Autor:
Andrew Chi-Yuen Chu, Xuqing Liu, Ray Kit Ng, Ronnie T.P. Poon, Xiao Qi Wang, Chung Mau Lo, Roberta Pang, Xiaoyan Ming, Wu Zhang, Lin Chen, Sai Wah Tsao, Sheung Tat Fan
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e72435 (2013)
PLoS ONE
PLoS ONE
Activation of the stem cell transcriptional circuitry is an important event in cancer development. Although cancer cells demonstrate a stem cell-like gene expression signature, the epigenetic regulation of pluripotency-associated genes in cancers rem