Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Andrew Carvalho"'
Autor:
Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter Germano, Kim Tang, Rajesh R. Iyengar, Mark G. Currie, John R. Hadcock, Christopher J. Winrow, Juli E. Jones
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating n
Externí odkaz:
https://doaj.org/article/b9dc10997df94c7186de03737efe4dd1
Autor:
Susana S. Correia, Rajesh R. Iyengar, Peter Germano, Kim Tang, Sylvie G. Bernier, Chad D. Schwartzkopf, Jenny Tobin, Thomas W.-H. Lee, Guang Liu, Sarah Jacobson, Andrew Carvalho, Glen R. Rennie, Joon Jung, Paul A. Renhowe, Elisabeth Lonie, Christopher J. Winrow, John R. Hadcock, Juli E. Jones, Mark G. Currie
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclas
Externí odkaz:
https://doaj.org/article/77b2ed6c8b9c4de4b87274d76d632880
Autor:
Daniel P. Zimmer, Courtney M. Shea, Jenny V. Tobin, Boris Tchernychev, Peter Germano, Kristie Sykes, Ali R. Banijamali, Sarah Jacobson, Sylvie G. Bernier, Renee Sarno, Andrew Carvalho, Yueh-tyng Chien, Regina Graul, Emmanuel S. Buys, Juli E. Jones, James D. Wakefield, Gavrielle M. Price, Jennifer G. Chickering, G. Todd Milne, Mark G. Currie, Jaime L. Masferrer
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi
Externí odkaz:
https://doaj.org/article/e994be112c3a40db87031271143e9556
Autor:
Sylvie G. Bernier, Peter Germano, Christopher J. Winrow, Chad D. Schwartzkopf, Susana S. Correia, Kim Tang, Juli E. Jones, Sam Rivers, Elisabeth Lonie, Guang Liu, Sarah Jacobson, Andrew Carvalho, Jenny Tobin, John R. Hadcock, Emily Atwater, Rajesh R. Iyengar, Mark G. Currie
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinfla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199a830a1937f260ccf762e3f641c144
https://doi.org/10.1186/s12974-021-02275-z
https://doi.org/10.1186/s12974-021-02275-z
Autor:
Andrew Carvalho, Kim Tang, Christopher J. Winrow, John R. Hadcock, Sarah Jacobson, Jenny Tobin, Elisabeth Lonie, Sylvie G. Bernier, Thomas W.-H. Lee, Susana S. Correia, Rennie Glen Robert, Chad D. Schwartzkopf, Joon Jung, Peter Germano, Guang Liu, Juli E. Jones, Mark G. Currie, Paul Allan Renhowe, Rajesh R. Iyengar
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32016c7ebcec298b36c97328d53b8a4
https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
Autor:
Jia Lei, Joon Jung, Sylvie G. Bernier, Joel D. Moore, Glen Rennie, Mermerian Ara, Nicholas Robert Perl, Thomas Wai-Ho Lee, Andrew Carvalho, Barden Timothy Claude, Peter Germano, Jenny Tobin, Colleen Hudson, Renee Deming, Rajesh R. Iyengar, Takashi Nakai, G-Yoon Jamie Im, Paul A. Renhowe, Daniel P. Zimmer, Elise Kim
Publikováno v:
Bioorganicmedicinal chemistry letters. 40
Soluble guanylate cyclase (sGC) is a clinically validated therapeutic target in the treatment of pulmonary hypertension. Modulators of sGC have the potential to treat diseases that are affected by dysregulation of the NO-sGC-cGMP signal transduction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee9de2bad2e2d41649c98451bf1e9a94
https://pubmed.ncbi.nlm.nih.gov/33662540
https://pubmed.ncbi.nlm.nih.gov/33662540
Publikováno v:
Diabetes. 69
Background: Praliciguat (IW-1973) is an sGC stimulator in clinical development as a potential treatment for diabetic kidney disease. In animal models, praliciguat distributes broadly to tissues and elicits hemodynamic, anti-inflammatory, anti-fibroti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba9de97f4ff65247388bb7f43837aa0
https://doi.org/10.2337/db20-124-lb
https://doi.org/10.2337/db20-124-lb
Autor:
Jenny Tobin, Albert T. Profy, Ali R. Banijamali, Mark G. Currie, James Wakefield, Jaime L. Masferrer, G. Todd Milne, Daniel P. Zimmer, Andrew Carvalho, Peter Germano, Barden Timothy Claude
Publikováno v:
Pharmacology Research & Perspectives
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
The pharmacokinetics (PK), metabolism, excretion, mass balance, and tissue distribution of [14C]praliciguat were evaluated following oral administration of a 3‐mg/kg dose in Sprague‐Dawley rats and in a quantitative whole‐body autoradiography (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b3e4df24159164c127118e8e21c0b4
http://europepmc.org/articles/PMC7171252
http://europepmc.org/articles/PMC7171252
Autor:
Sarah Jacobson, Jenny Tobin, Renee Sarno, Jaime L. Masferrer, Andrew Carvalho, Boris Tchernychev, Yueh-Tyng Chien, G. Todd Milne, Jennifer G. Chickering, Peter Germano, Ali R. Banijamali, Gavrielle M Price, Emmanuel S. Buys, James Wakefield, Regina Graul, Juli E. Jones, Courtney Shea, Sylvie G. Bernier, Daniel P. Zimmer, Kristie Sykes, Mark G. Currie
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 11 (2020)
Frontiers in Pharmacology, Vol 11 (2020)
Nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic 3',5' GMP (cGMP) signaling plays a central role in regulation of diverse processes including smooth muscle relaxation, inflammation, and fibrosis. sGC is activated by the short-lived physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235faf214a0dad4f1fdd0e1ad72b1cd8
https://pubmed.ncbi.nlm.nih.gov/32322204
https://pubmed.ncbi.nlm.nih.gov/32322204
Autor:
Andrew Carvalho, Ali R. Banijamali, Alicja Borowik, Frank Scheffler, Deepa Karunakaran, Jonathan Steele, Julia Shanu-Wilson, Richard Phipps, Ravi Manohar, Liam Evans
Publikováno v:
Drug Metabolism and Pharmacokinetics. 35:S25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::665b53ad7c8fa1ca0c262a47252cf155
https://doi.org/10.1016/j.dmpk.2020.04.011
https://doi.org/10.1016/j.dmpk.2020.04.011