Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Andrew Caerwyn Williams"'
Autor:
Benjamin Wilenkin, Brian J. Eastwood, Emanuele Sher, Birgit T. Priest, Andrew Caerwyn Williams, Kevin D. Burris
Publikováno v:
Assay and drug development technologies. 17(7)
Relief from chronic pain continues to represent a large unmet need. The voltage-gated potassium channel Kv7.2/7.3, also known as KCNQ2/3, is a key contributor to the control of resting membrane potential and excitability in nociceptive neurons and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb4d1b91e38bd3e0557f0b0da078a9a3
https://pubmed.ncbi.nlm.nih.gov/31634018
https://pubmed.ncbi.nlm.nih.gov/31634018
Publikováno v:
Tetrahedron Letters. 53:4657-4660
Acid-catalysed cyclisations of the 2-aminoethyl styrene derivatives 9 give good to excellent yields of the corresponding tetrahydroisoquinolines 7 by an intramolecular hydroamination reaction, which represents an alternative and potentially more flex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab585f7643e4049f800e77a197ad6649
https://doi.org/10.1016/j.tetlet.2012.06.091
https://doi.org/10.1016/j.tetlet.2012.06.091
Autor:
Chunjin Ding, Beverly A. Heinz, Mirko Moroni, Andrew Caerwyn Williams, Lisa M. Broad, Elizabeth A. Folly, Ruud Zwart, Adrian J. Mogg, Emanuele Sher, Anna L. Carbone, Deyi Zhang, Isabel Bermudez
Publikováno v:
Molecular Pharmacology. 73:1838-1843
Sazetidine-A has been recently proposed to be a "silent desensitizer" of alpha4beta2 nicotinic acetylcholine receptors (nAChRs), implying that it desensitizes alpha4beta2 nAChRs without first activating them. This unusual pharmacological property of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2abbdfc89701dbf1a4bd649a35e8784
https://doi.org/10.1124/mol.108.045104
https://doi.org/10.1124/mol.108.045104
Publikováno v:
Tetrahedron. 62:9247-9257
Selenocyclisations of the homoallylic sulfonamides [e.g., 26, 28 and 30] using phenylselanyl halides lead exclusively to β-selanyl-pyrrolidines [e.g., 27, 29 and 31] by an overall 5-endo-trig pathway, but with considerable variations in the stereoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd21b7b2b4ce513e0edcad06bc59f406
https://doi.org/10.1016/j.tet.2006.07.018
https://doi.org/10.1016/j.tet.2006.07.018
Autor:
Andrew Caerwyn Williams, Michael J. Corr, Andrew H. Payne, John A. Murphy, Neil Muir, Franziska Schoenebeck, Stuart Lang, Tanweer A. Khan
Publikováno v:
Tetrahedron Letters. 46:4027-4030
The phosphorus based radical precursors N-ethylpiperidine hypophosphite (EPHP) and diethylphosphine oxide (DEPO) are efficient reagents for carrying out the formation of seven- and eight-membered rings. Esters and amides were successfully converted i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5543effec3ab0090747dfe631063f5ca
https://doi.org/10.1016/j.tetlet.2005.04.032
https://doi.org/10.1016/j.tetlet.2005.04.032
Publikováno v:
Tetrahedron Letters. 53:4654-4656
Optimised conditions are reported for Suzuki–Miyaura couplings between N-tosyl-2-bromo-benzylamines and -phenethylamines with vinylboronic acids, using pre-mixes of catalyst, ligand and base, leading to the corresponding 2-tosylaminomethyl- and 2-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0642e1a767e09c3043c2d440e70c0e9
https://doi.org/10.1016/j.tetlet.2012.06.089
https://doi.org/10.1016/j.tetlet.2012.06.089
Publikováno v:
Synlett. 23:1667-1669
Acid-catalysed intramolecular hydroaminations of 2-alkenylarylethylamine derivatives lead smoothly to isoindolines via benzylic carbenium ion generation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0454898a000c67ca456cbe67aaa51c8e
https://doi.org/10.1055/s-0031-1291155
https://doi.org/10.1055/s-0031-1291155
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :1411-1420
Methodology has been established for the formation of enantiomerically enriched α-amino acids using palladium-catalysed allylic amination. The formation of enantiomerically enriched allylamines has been achieved with high enantioselectivity. Oxidati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e3f6aff3452a7d5b0d1566588f1b0bc
https://doi.org/10.1039/a606586d
https://doi.org/10.1039/a606586d
Publikováno v:
Journal of Molecular Catalysis A: Chemical. 99:41-46
Microgels incorporating 2-(tetradecyldimethylammonio)ethyl methacrylate bromide have been prepared by emulsion polymerisation with methyl methacrylate, 2-ethoxyethyl methacrylate and ethylene glycol dimethacrylate in the molar ratio 0.15:0.45:0.30:0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e81b7150a9949b8e35220b0a67c655cc
https://doi.org/10.1016/1381-1169(95)00010-0
https://doi.org/10.1016/1381-1169(95)00010-0
Publikováno v:
ChemInform. 43
Acid-catalyzed cyclizations of 2-aminoethyl styrene derivatives (I), (III) and (V) give the corresponding tetrahydroisoquinolines (II), (IV), and (VI) by an intramolecular hydroamination reaction, which represents an alternative and potentially more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c4aa5e8a1bf1de4c4591f0be87baff0
https://doi.org/10.1002/chin.201248158
https://doi.org/10.1002/chin.201248158