Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Andrew C. Zygmunt"'
Autor:
Willemijn Groenendaal, Francis A Ortega, Armen R Kherlopian, Andrew C Zygmunt, Trine Krogh-Madsen, David J Christini
Publikováno v:
PLoS Computational Biology, Vol 11, Iss 4, p e1004242 (2015)
The traditional cardiac model-building paradigm involves constructing a composite model using data collected from many cells. Equations are derived for each relevant cellular component (e.g., ion channel, exchanger) independently. After the equations
Externí odkaz:
https://doaj.org/article/955d66251d1f439a96259fddd41f95af
Autor:
Charles Antzelevitch, Serge Sicouri, Yoshino Minoura, Andrew C. Zygmunt, José M. Di Diego, Hector Barajas-Martinez, Dan Hu
Publikováno v:
Journal of Cardiovascular Electrophysiology. 23:423-432
Antidepressant-Induced Brugada Syndrome. Introduction: Tricyclic antidepressants are known to induce cardiac arrhythmias at therapeutic or supratherapeutic doses. The tricyclic antidepressant, amitriptyline, is reported to induce ST segment elevation
Autor:
Wu L, Andrew C. Zygmunt, Fabiana S. Scornik, Robert J. Goodrow, Guillermo J. Pérez, Jonathan M. Cordeiro, Di Diego Jm, Luiz Belardinelli, Alexander Burashnikov, Jeffrey M. Fish, Fraser H, Charles Antzelevitch
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 9:S65-S83
Ranolazine is a novel antianginal agent capable of producing anti-ischemic effects at plasma concentrations of 2 to 6 microM without a significant reduction of heart rate or blood pressure. This review summarizes the electrophysiologic properties of
Autor:
Jeffrey M. Fish, José M. Di Diego, Andrew C. Zygmunt, Fabiana S. Scornik, Robert J. Goodrow, Jonathan M. Cordeiro, Charles Antzelevitch, Guillermo J. Pérez
Publikováno v:
Circulation. 106:2004-2011
Background— The Brugada syndrome displays an autosomal dominant mode of transmission with low penetrance. Despite equal genetic transmission of the disease, the clinical phenotype is 8 to 10 times more prevalent in males than in females. The basis
Autor:
Alexander, Burashnikov, José M, Di Diego, Hector, Barajas-Martínez, Dan, Hu, Andrew C, Zygmunt, Jonathan M, Cordeiro, N Sydney, Moise, Bruce G, Kornreich, Luiz, Belardinelli, Charles, Antzelevitch
Publikováno v:
Circulation. Heart failure. 7(4)
Background— There is a critical need for safer and more effective pharmacological management of atrial fibrillation (AF) in the setting of heart failure (HF). Methods and Results— This study investigates the electrophysiological, antiarrhythmic,
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 278:H1671-H1678
This study examines the amplitude of sodium-calcium exchange current ( I NaCa) in epicardial, midmyocardial, and endocardial canine ventricular myocytes. Whole cell currents were recorded at 37°C using standard or perforated-patch voltage-clamp tech
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 275:H1979-H1992
The contributions of electrogenic sodium/calcium exchange current ( I NaCa), calcium-activated chloride conductance [ I Cl(Ca)], and calcium-activated nonselective cation conductance to delayed afterdepolarizations (DAD) were examined. Nonselective c
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 272:H1-H11
Tetrodotoxin (TTX) or substitution of external Na+ reduces the 4-aminopyridine-sensitive transient outward current (Ito1) in rat ventricular myocytes. We investigated the outcome of reducing external sodium on the kinetics, gating, and selectivity of
Autor:
Alexander Burashnikov, Jonathan M. Cordeiro, Tanya Zeina, Vladislav V. Nesterenko, Jacqueline A. Treat, Robert J. Goodrow, Andrew C. Zygmunt, Charles Antzelevitch, José M. Di Diego, Casey White, Brian K. Panama
Background : Developmental changes in the electrical characteristics of the ventricular myocardium are not well defined. This study examines the contribution of inwardly rectifying K + current (I K1 ), transient outward K + current (I to ), delayed r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcd0443e96f9b6576744e1770cc7c85
https://europepmc.org/articles/PMC3837711/
https://europepmc.org/articles/PMC3837711/
Autor:
Sridharan Rajamani, Charles Antzelevitch, Luiz Belardinelli, Andrew C. Zygmunt, Vladislav V. Nesterenko
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 301(4)
Block of Na+ channel conductance by ranolazine displays marked atrial selectivity that is an order of magnitude higher that of other class I antiarrhythmic drugs. Here, we present a Markovian model of the Na+ channel gating, which includes activation