Výsledky vyhledávání - "Andrew C. Selfridge"

Mechanisms of CO 2 ‐dependent regulation of NFκB signaling

Autor: Alex Kreigsheim, Eoin P. Cummins, Ciara E. Keogh, Javier Rodriguez, Carsten C. Scholz, Andrew C. Selfridge

Publikováno v: The FASEB Journal. 32

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33bb16d2fdf3a6b0c431508a8dacb0b6
https://doi.org/10.1096/fasebj.2018.32.1_supplement.864.4

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Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD

Autor: Sophie Van Welden, Pieter Hindryckx, Andrew C. Selfridge

Publikováno v: Nature reviews. Gastroenterologyhepatology. 14(10)

IBD is associated with markedly reduced intestinal mucosal oxygen levels. In this Review, the authors discuss the role of mucosal hypoxia and hypoxia-induced signalling in IBD and identify potential targets for therapies, focusing on the cell-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d340f1907af730cfbc9e19281afd73a
https://pubmed.ncbi.nlm.nih.gov/28853446

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Carbon dioxide-sensing in organisms and its implications for human disease

Autor: Andrew C. Selfridge, Cormac T. Taylor, Peter H. S. Sporn, Jacob I. Sznajder, Eoin P. Cummins

Publikováno v: Cellular and Molecular Life Sciences. 71:831-845

The capacity of organisms to sense changes in the levels of internal and external gases and to respond accordingly is central to a range of physiologic and pathophysiologic processes. Carbon dioxide, a primary product of oxidative metabolism is one s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4d070479a9ed12b20711a03f367223
https://doi.org/10.1007/s00018-013-1470-6

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Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO

Autor: Ciara E, Keogh, Carsten C, Scholz, Javier, Rodriguez, Andrew C, Selfridge, Alexander, von Kriegsheim, Eoin P, Cummins

Publikováno v: The Journal of biological chemistry. 292(27)

CO2 is a physiological gas normally produced in the body during aerobic respiration. Hypercapnia (elevated blood pCO2 >≈50 mm Hg) is a feature of several lung pathologies, e.g. chronic obstructive pulmonary disease. Hypercapnia is associated with i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fd9e6b7b4187747511ceb0a72fe91bb
https://pubmed.ncbi.nlm.nih.gov/28507099

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REST is a hypoxia-responsive transcriptional repressor

Autor: Miguel A S, Cavadas, Marion, Mesnieres, Bianca, Crifo, Mario C, Manresa, Andrew C, Selfridge, Ciara E, Keogh, Zsolt, Fabian, Carsten C, Scholz, Karen A, Nolan, Liliane M A, Rocha, Murtaza M, Tambuwala, Stuart, Brown, Anita, Wdowicz, Danielle, Corbett, Keith J, Murphy, Catherine, Godson, Eoin P, Cummins, Cormac T, Taylor, Alex, Cheong

Publikováno v: Scientific Reports

Cellular exposure to hypoxia results in altered gene expression in a range of physiologic and pathophysiologic states. Discrete cohorts of genes can be either up- or down-regulated in response to hypoxia. While the Hypoxia-Inducible Factor (HIF) is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c97e27527623692d9529c952fc574ad
https://pubmed.ncbi.nlm.nih.gov/27531581

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Hypercapnia Suppresses the HIF-dependent Adaptive Response to Hypoxia

Autor: Eric L. Campbell, Andrew C. Selfridge, Carsten C. Scholz, Peter H. S. Sporn, Cormac T. Taylor, Jacob I. Sznajder, Lynn C. Welch, Eoin P. Cummins, Emilia Lecuona, Miguel Cavadas, Sean P. Colgan, Kim E. Barrett

Publikováno v: Selfridge, A C, Cavadas, M A S, Scholz, C C, Campbell, E L, Welch, L C, Lecuona, E, Colgan, S P, Barrett, K E, Sporn, P H S, Sznajder, J I, Cummins, E P & Taylor, C T 2016, ' Hypercapnia suppresses the HIF-dependent adaptive response to hypoxia ', Journal of Biological Chemistry, vol. 291, no. 22, pp. 11800-11808 . https://doi.org/10.1074/jbc.M116.713941

Molecular oxygen and carbon dioxide are the primary gaseous substrate and product of oxidative metabolism, respectively. Hypoxia (low oxygen) and hypercapnia (high carbon dioxide) are co-incidental features of the tissue microenvironment in a range o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bb644f50c460d842eb9db3b5a6d99aa
https://www.zora.uzh.ch/id/eprint/124670/

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REST mediates resolution of HIF-dependent gene expression in prolonged hypoxia

Autor: Cormac T. Taylor, Alex Cheong, Bianca Crifo, Miguel Cavadas, Mario C. Manresa, Carsten C. Scholz, Marion Mesnieres, Eoin P. Cummins, Andrew C. Selfridge

Publikováno v: Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The hypoxia-inducible factor (HIF) is a key regulator of the cellular response to hypoxia which promotes oxygen delivery and metabolic adaptation to oxygen deprivation. However, the degree and duration of HIF-1α expression in hypoxia must be careful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cd75d4e8c80cf59471970ab8ffea454
https://www.zora.uzh.ch/id/eprint/119602/

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Hypoxia modulates infection of epithelial cells by Pseudomonas aeruginosa

Autor: Karim Asehnoune, Siobhán McClean, Cormac T. Taylor, Andrew C. Selfridge, Kirsten Schaffer, Alexis Broquet, Bettina Schaible

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56491 (2013)
PLoS ONE

Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen commonly associated with lung and wound infections. Hypoxia is a frequent feature of the microenvironment of infected tissues which induces the expression of genes associated with in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1be2b597630854566678734150aa1844
http://europepmc.org/articles/PMC3572047?pdf=render

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