Development and Application of a Slot-Blot Assay Using the Damage Sensing Protein Atl1 to Detect and Quantify O6-Alkylated Guanine Bases in DNA

Autor: Hanum Yaakub, Anthony Howell, Geoffrey P. Margison, Andrew C. Povey

Publikováno v: Toxics, Vol 12, Iss 9, p 649 (2024)

Humans are unavoidably exposed to numerous different mutagenic DNA alkylating agents (AAs), but their role in the initiation of cancers is uncertain, in part due to difficulties in assessing human exposure. To address this, we have developed a screen

Externí odkaz: https://doaj.org/article/a13976f963d94d8893779bfc6bf015bf

Geochemical compositional controls on DNA strand breaks induced in in vitro cell-free assays by crushed rock powders from the Panasqueira mine area, Portugal

Autor: Andrew C. Povey, David A. Polya, Hatim Badri

Publikováno v: Badri, H, Polya, D A & Povey, A C 2020, ' Geochemical compositional controls on DNA strand breaks induced in in vitro cell-free assays by crushed rock powders from the Panasqueira mine area, Portugal ', Environmental Geochemistry and Health . https://doi.org/10.1007/s10653-020-00653-9
Environmental Geochemistry and Health

DNA strand breaks are a common form of DNA damage that can contribute to chromosomal instability or gene mutations. Such strand breaks may be caused by exposure to heavy metals. The aim of this study was to assess the level of DNA strand breaks cause

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271098f2f62ffff9e6dda2f4672a79a7
https://doi.org/10.1007/s10653-020-00653-9

O-283 Recall ability of pesticide users in Uganda and the UK: results from the IMPRESS study

Autor: Anne-Helen Harding, William Mueller, Andrew C. Povey, Hani Mohamed, Aggrey Atuhaire, Kate Jones, Martie van Tongeren, Samuel Fuhrimann, Ruth Mubeezi, Ioannis Basinas, Iris van den Brenk, Karen S. Galea, Hans Kromhout

Publikováno v: Oral Presentations.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a236268b57821536b65d9ab10d437bc9
https://doi.org/10.1136/oem-2021-epi.97

PON1 increases cellular DNA damage by lactone substrates

Autor: G. P. Margison, Tarza Siahmansur, S. Shangula, Y. Liu, Handrean Soran, Mohammad Noori, I. Ahmad, Andrew C. Povey

Publikováno v: Shangula, S, Noori, M, Ahmad, I, Margison, G P, Liu, Y, Siahmansur, T, Soran, H & Povey, A C 2019, ' PON1 increases cellular DNA damage by lactone substrates ', Archives of Toxicology . https://doi.org/10.1007/s00204-019-02475-w

Paraoxonase 1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme that by hydrolysing exogenous and endogenous substrates can provide protection against substrate induced toxicity. To investigate the extent to which PON1 provides protection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71cfcae081c4a07b1dc459cc89ee60c5
https://doi.org/10.1007/s00204-019-02475-w

Insufficient respiratory hazard identification in the safety data sheets for cleaning and disinfection products used in healthcare organisations across England and Wales

Autor: Martie van Tongeren, Martin Seed, Sewon Lee, Andrew C. Povey

Publikováno v: Occupational and environmental medicine. 78(4)

BackgroundExposure to cleaning and disinfection products has been associated with respiratory disorders such as asthma in cleaning and healthcare workers. Safety data sheets (SDSs) provide information on hazardous chemicals that are present in produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b3e0cfce0eb490bad24bd02923d8fc
https://pubmed.ncbi.nlm.nih.gov/35027463