Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Andrew C. Mercer"'
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/3a30748c0a64474dbbe5f7706d739fec
Autor:
Bradley S. Hollidge, Hayley B. Carroll, Randolph Qian, Madison L. Fuller, April R. Giles, Andrew C. Mercer, Olivier Danos, Ye Liu, Joseph T. Bruder, Jared B. Smith
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
Understanding the kinetics and durability of AAV-mediated transgene expression in the brain is essential for conducting basic neuroscience studies as well as for developing gene therapy approaches for CNS diseases. Here, we characterize and compare t
Externí odkaz:
https://doaj.org/article/211584121410446c9ae0775d23eb5024
Publikováno v:
Biotechnology and Bioengineering. 118:2001-2015
Age-related macular degeneration (AMD) associated with dysfunction of retinal pigment epithelial (RPE) cells is the most common cause of untreatable blindness. To advance gene therapy as a viable treatment for AMD there is a need for technologies tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc3f0e6c73d95da73fa657491e81690
https://doi.org/10.1002/bit.27713
https://doi.org/10.1002/bit.27713
Autor:
Emre Firlar, Keith A. Webber, Samantha A. Yost, Andrew C. Mercer, Olivier Danos, Ye Liu, Jason T. Kaelber
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Adeno-associated viruses (AAVs) are used as in vivo gene-delivery vectors in gene-therapy products and have been heavily investigated for numerous indications. Over 100 naturally occurring AAV serotypes and variants have been isolated from primate sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b38b4b679fe7d628db691904504b04
https://doi.org/10.1107/s2053230x20000308
https://doi.org/10.1107/s2053230x20000308
Publikováno v:
Nucleic Acids Research
The serine recombinases are a diverse family of modular enzymes that promote high-fidelity DNA rearrangements between specific target sites. Replacement of their native DNA-binding domains with custom-designed Cys2–His2 zinc-finger proteins results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d3a6a5ade54d99539b0354661d0b36
https://doi.org/10.1093/nar/gkt1389
https://doi.org/10.1093/nar/gkt1389
Publikováno v:
ACS Synthetic Biology
The construction of increasingly sophisticated synthetic biological circuits is dependent on the development of extensible tools capable of providing specific control of gene expression in eukaryotic cells. Here, we describe a new class of synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f926dd01893a8e247c83882f21020bbd
http://europepmc.org/articles/PMC4097969
http://europepmc.org/articles/PMC4097969
Publikováno v:
Nucleic Acids Research
Zinc-finger recombinases (ZFRs) represent a potentially powerful class of tools for targeted genetic engineering. These chimeric enzymes are composed of an activated catalytic domain derived from the resolvase/invertase family of serine recombinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434cae7921f92d06ee7fd5d144e47761
https://doi.org/10.1093/nar/gkt071
https://doi.org/10.1093/nar/gkt071
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research; Vol 40
Nucleic Acids Research; Vol 40
Site-specific recombinases are powerful tools for genome engineering. Hyperactivated variants of the resolvase/invertase family of serine recombinases function without accessory factors, and thus can be re-targeted to sequences of interest by replaci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76033048ddb94603a18c4daa17c2dcb3
Publikováno v:
Nucleic Acids Research
The development of new methods for gene addition to mammalian genomes is necessary to overcome the limitations of conventional genetic engineering strategies. Although a variety of DNA-modifying enzymes have been used to directly catalyze the integra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502a8a9e3d1928010ce5b6acd38015a3
https://doi.org/10.1093/nar/gkr421
https://doi.org/10.1093/nar/gkr421
Publikováno v:
ChemBioChem. 10:1091-1100
Carrier proteins are central to the biosynthesis of primary and secondary metabolites in all organisms. Here we describe metabolic labeling and manipulation of native acyl carrier proteins in both type I and II fatty acid synthases. By utilizing natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72c1fa9d4b1abffa2606eaeca7b9ace
https://doi.org/10.1002/cbic.200800838
https://doi.org/10.1002/cbic.200800838