Metabolomic profiling of Burkholderia cenocepacia in synthetic cystic fibrosis sputum medium reveals nutrient environment-specific production of virulence factors

Autor: Olakunle A. Jaiyesimi, Andrew C. McAvoy, David N. Fogg, Neha Garg

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract Infections by Burkholderia cenocepacia lead to life-threatening disease in immunocompromised individuals, including those living with cystic fibrosis (CF). While genetic variation in various B. cenocepacia strains has been reported, it remai

Externí odkaz: https://doaj.org/article/6dcc81b4117f43e08055b06a144a68e5

Immunogenicity and Efficacy of a Novel Multi-Antigenic Peptide Vaccine Based on Cross-Reactivity between Feline and Human Immunodeficiency Viruses

Autor: Bikash Sahay, Alek M. Aranyos, Meerambika Mishra, Andrew C. McAvoy, Marcus M. Martin, Riuyu Pu, Sayaka Shiomitsu, Keijiro Shiomitsu, Michael J. Dark, Missa P. Sanou, Shannon R. Roff, Mobeen H. Rathore, Janet K. Yamamoto

Publikováno v: Viruses, Vol 11, Iss 2, p 136 (2019)

For the development of an effective HIV-1 vaccine, evolutionarily conserved epitopes between feline and human immunodeficiency viruses (FIV and HIV-1) were determined by analyzing overlapping peptides from retroviral genomes that induced both anti-FI

Externí odkaz: https://doaj.org/article/0b2ca80d22f247ed953a086d80df7b09

Metabolomic profiling of Burkholderia cenocepacia in synthetic cystic fibrosis sputum medium reveals nutrient environment-specific production of virulence factors

Autor: David N. Fogg, Olakunle A. Jaiyesimi, Neha Garg, Andrew C. McAvoy

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports

Infections by Burkholderia cenocepacia lead to life-threatening disease in immunocompromised individuals, including those living with cystic fibrosis (CF). While genetic variation in various B. cenocepacia strains has been reported, it remains unclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71401448717d73a1c976a31ea4e77d4a
https://doaj.org/article/6dcc81b4117f43e08055b06a144a68e5

Differences in Cystic Fibrosis-Associated Burkholderia spp. Bacteria Metabolomes after Exposure to the Antibiotic Trimethoprim

Autor: Ricardo Silva, Andrew C. McAvoy, Neha Garg, Joanna B. Goldberg, Paxton H. Threatt, Olakunle A. Jaiyesimi, Tyler Seladi

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The Burkholderia cepacia complex is a group of closely related bacterial species with large genomes that infect immunocompromised individuals and those living with cystic fibrosis. Some of these sp...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53b0d8b0174358b0a1ec0f9fb05c1b7
https://doi.org/10.1021/acsinfecdis.9b00513

A community resource for paired genomic and metabolomic data mining

Autor: Lars Ridder, Tim S. Bugni, Jamshid Amiri Moghaddam, Florian Huber, Elke Dittmann, Kelly C. Weldon, Louis-Félix Nothias, Douglas Sweeney, Mingxun Wang, Paul R. Jensen, Letícia V. Costa-Lotufo, Christine Beemelmanns, Katherine R. Duncan, Nadine Ziemert, Xuanji Li, Dulce G. Guillén Matus, Chao Du, Neha Garg, Jae Seoun Hur, Elizabeth I. Parkinson, Raphael Reher, Nicholas J. Tobias, Alex A. Blacutt, Emily C Pierce, Michelle Schorn, J. Michael Beman, Simon Rogers, María Victoria Berlanga-Clavero, Martin Baunach, Fan Zhang, Deepa D. Acharya, Harald Gross, Hamada Saad, M. Caroline Roper, Anna Edlund, Jason M. Crawford, Daniel Petras, Alexandra Calteau, Benjamin-Florian Hempel, Seoung Rak Lee, Max Crüsemann, Neil L. Kelleher, Hosein Mohimani, David P. Fewer, Shaurya Chanana, Carmen Saenz, Lena Gerwick, Ki-Hyun Kim, Roderich D. Süssmuth, Jörn Piel, Diego Romero, Marnix H. Medema, Anelize Bauermeister, Christopher Drozd, Regan J. Thomson, Anne Boullie, Michael W. Mullowney, Karine Pires, Andrew C. McAvoy, Alexander A. Aksenov, Saefuddin Aziz, Raquel Castelo-Branco, Julia M. Gauglitz, Mitchell N. Muskat, Bart Cuypers, Emily C. Gentry, Yi Yuan Lee, Eric J. N. Helfrich, Tam Dang, Pieter C. Dorrestein, Liu Cao, Rachel J. Dutton, Gilles P. van Wezel, Helge B. Bode, Margherita Sosio, Asker Daniel Brejnrod, Gajender Aleti, Leonard Kaysser, Amaro E. Trindade-Silva, Willam W. Metcalf, Irina Koester, Tiago Leao, Katherine D. Bauman, Jessica C. Little, Evgenia Glukhov, Ellis C. O’Neill, Justin J. J. van der Hooft, Alyssa M. Demko, Alexander B. Chase, Marc G. Chevrette, Bradley S. Moore, Christian Martin H, Kapil Tahlan, Cameron R. Currie, Allegra T. Aron, Muriel Gugger, Kyo Bin Kang, Víctor J. Carrión, Michael J. Rust, Gabriele M. König, Carlos Molina-Santiago, Søren J. Sørensen, Marianna Iorio, Jean-Claude Dujardin, Daniel Männle, Chung Sub Kim, Laura M. Sanchez, Katherine N. Maloney, Stefan Verhoeven, Tristan de Rond

Publikováno v: Nature Chemical Biology
Nature Chemical Biology, Nature Publishing Group, 2021, ⟨10.1038/s41589-020-00724-z⟩
Nature Chemical Biology 17 (2021) 4
Nature Chemical Biology, 17(4), 363-368
Nature Chemical Biology, 17(4), 363-368. Nature Publishing Group
Nat Chem Biol
Schorn, M A, Verhoeven, S, Ridder, L, Huber, F, Acharya, D D, Aksenov, A A, Aleti, G, Moghaddam, J A, Aron, A T, Aziz, S, Bauermeister, A, Bauman, K D, Baunach, M, Beemelmanns, C, Beman, J M, Berlanga-Clavero, M V, Blacutt, A A, Bode, H B, Boullie, A, Brejnrod, A, Bugni, T S, Calteau, A, Cao, L, Carrión, V J, Castelo-Branco, R, Chanana, S, Chase, A B, Chevrette, M G, Costa-Lotufo, L V, Crawford, J M, Currie, C R, Cuypers, B, Dang, T, de Rond, T, Demko, A M, Dittmann, E, Du, C, Drozd, C, Dujardin, J-C, Dutton, R J, Edlund, A, Fewer, D P, Garg, N, Gauglitz, J M, Gentry, E C, Gerwick, L, Glukhov, E, Gross, H, Gugger, M, Matus, D G G, Helfrich, E J N, Hempel, B-F, Hur, J-S, Iorio, M, Jensen, P R, Kang, K B, Kaysser, L, Kelleher, N L, Kim, C S, Kim, K H, Koester, I, König, G M, Leao, T, Lee, S R, Lee, Y-Y, Li, X, Little, J C, Maloney, K N, Männle, D, Martin H., C, McAvoy, A C, Metcalf, W W, Mohimani, H, Molina-Santiago, C, Moore, B S, Mullowney, M W, Muskat, M, Nothias, L-F, O'Neill, E C, Parkinson, E I, Petras, D, Piel, J, Pierce, E C, Pires, K, Reher, R, Romero, D, Roper, M C, Rust, M, Saad, H, Saenz, C, Sanchez, L M, Sørensen, S J, Sosio, M, Süssmuth, R D, Sweeney, D, Tahlan, K, Thomson, R J, Tobias, N J, Trindade-Silva, A E, van Wezel, G P, Wang, M, Weldon, K C, Zhang, F, Ziemert, N, Duncan, K R, Crüsemann, M, Rogers, S, Dorrestein, P C, Medema, M H & van der Hooft, J J J 2021, ' A community resource for paired genomic and metabolomic data mining ', Nature Chemical Biology, vol. 17, no. 4, pp. 363-368 . https://doi.org/10.1038/s41589-020-00724-z
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Chemical Biology, 2021, ⟨10.1038/s41589-020-00724-z⟩
Nature chemical biology

International audience; Genomics and metabolomics are widely used to explore specialized metabolite diversity. The Paired Omics Data Platform is a community initiative to systematically document links between metabolome and (meta)genome data, aiding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28bab3cd944ad174c6905009e2841f0d
https://hal-pasteur.archives-ouvertes.fr/pasteur-03153704/document