Výsledky vyhledávání - "Andrew C. Leary"

Pharmacokinetics and Pharmacodynamics of Intranasal Insulin Spray (Nasulin™) Administered to Healthy Male Volunteers: Influence of the Nasal Cycle

Autor: Andrew C. Leary, Kathleen Cussen, Robert M. Stote, Muiris Dowling, Jackie O'Brien

Publikováno v: Journal of Diabetes Science and Technology. 2:1054-1060

The pharmacokinetics and pharmacodynamics of a Bentley Pharmaceuticals proprietary intranasal (IN) insulin formulation (Nasulin) were studied in healthy volunteers.Thirteen fasting healthy male volunteers received five doses of medication (one dose o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f688b863393fd517879fdf1a727509
https://doi.org/10.1177/193229680800200613

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Pharmacokinetics and Pharmacodynamics of Intranasal Insulin Administered to Patients with Type 1 Diabetes: A Preliminary Study

Autor: Robert M. Stote, William P. Leary, Jackie O'Brien, Brendan Buckley, Andrew C. Leary, Kathleen Cussen

Publikováno v: Diabetes Technology & Therapeutics. 8:81-88

The pharmacokinetics and pharmacodynamics of a Bentley Pharmaceuticals (Exeter, NH) proprietary insulin formulation designed for intranasal administration were studied in patients with type 1 diabetes, using subcutaneous insulin or placebo as compara

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ba3d7b23ac3c97db32a696d646b958c
https://doi.org/10.1089/dia.2006.8.81

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Physical activity level is an independent predictor of the diurnal variation in blood pressure

Autor: Thomas M. MacDonald, Mike Murphy, Andrew C. Leary, Peter T. Donnan

Publikováno v: Journal of Hypertension. 18:405-410

The aim of this study was to define the relationship between physical activity and the magnitude of the percentage fall in blood pressure at night (nocturnal dip).We simultaneously monitored 24-h ambulatory blood pressure and measured physical activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f1dfe75b7bf4251e4d8a9ce5cc50dab
https://doi.org/10.1097/00004872-200018040-00008

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Pharmacokinetics and pharmacodynamics of intranasal insulin administered to healthy subjects in escalating doses

Autor: H J Breedt, Robert M. Stote, Andrew C. Leary, Brendan Buckley, Jackie O'Brien

Publikováno v: Diabetes technologytherapeutics. 7(1)

This exploratory study examined the pharmacokinetics and pharmacodynamics of a Bentley Pharmaceuticals, Inc. (North Hampton, NH) proprietary insulin formulation utilizing CPE-215 technology designed for intranasal administration.Eight fasting healthy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e627b7689861c724c5f77074e8570945
https://pubmed.ncbi.nlm.nih.gov/15738710

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The white-coat effect is associated with increased blood pressure reactivity to physical activity

Autor: Andrew C. Leary, Peter T. Donnan, Thomas M. MacDonald, Michael B. Murphy

Publikováno v: Blood pressure monitoring. 7(4)

Objective The aim of this study was to test the hypothesis that blood pressure (BP) reactivity to the stress of a clinic visit, the so-called white-coat effect, is associated with increased BP reactivity to physical activity. Design Patients referred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcf212f826416e6bf0f78c7b7ccd621
https://pubmed.ncbi.nlm.nih.gov/12198336

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The influence of physical activity on the variability of ambulatory blood pressure

Autor: Michael B. Murphy, Peter T. Donnan, Andrew C. Leary, Thomas M. MacDonald

Publikováno v: American journal of hypertension. 13(10)

The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneousl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::860d2ce96c6fad8aca6ee05a2d575613
https://pubmed.ncbi.nlm.nih.gov/11041160

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