Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Andrew C. Larner"'
Autor:
Michela Grillo, Carolyn Palmer, Nadine Holmes, Fei Sang, Andrew C Larner, Rahul Bhosale, Peter E Shaw
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244255 (2020)
Reactive oxygen species are bona fide intracellular second messengers that influence cell metabolism and aging by mechanisms that are incompletely resolved. Mitochondria generate superoxide that is dis-mutated to hydrogen peroxide, which in turn oxid
Externí odkaz:
https://doaj.org/article/382e7e3dce3049d0b0548e5a4ae31678
Autor:
Jennifer D Sisler, Magdalena Morgan, Vidisha Raje, Rebecca C Grande, Marta Derecka, Jeremy Meier, Marc Cantwell, Karol Szczepanek, William J Korzun, Edward J Lesnefsky, Thurl E Harris, Colleen M Croniger, Andrew C Larner
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144444 (2015)
The transcription factor STAT1 plays a central role in orchestrating responses to various pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, the antigrowth, and immune surveillance effects of interferons an
Externí odkaz:
https://doaj.org/article/10a097becac749e9bfee43712bf8bf5b
Autor:
Nadine Holmes, Peter E. Shaw, Fei Sang, Michela Grillo, Rahul Bhosale, Andrew C. Larner, Carolyn Palmer
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0244255 (2020)
PLoS ONE
PLoS ONE
Reactive oxygen species are bona fide intracellular second messengers that influence cell metabolism and aging by mechanisms that are incompletely resolved. Mitochondria generate superoxide that is dis-mutated to hydrogen peroxide, which in turn oxid
Autor:
Michael R. Waters, Moonjung Hyun, Daniel H. Conrad, Thurl E. Harris, Vidisha Raje, Jeremy Meier, Andrew C. Larner, Jared S. Farrar, Marc Cantwell, Francesco S. Celi, Joseph C. Lownik
Publikováno v:
Cytokine. 111
Thermogenic fat is a promising target for new therapies in diabetes and obesity. Understanding how thermogenic fat develops is important to develop rational strategies to treat obesity. Previously, we have shown that Tyk2 and STAT3, part of the JAK-S
Autor:
Julia Bollrath, Charles K. Pallangyo, Tiago De Oliveira, Melek C. Arkan, Takaji Matsutani, David Horst, Jaba Gamrekelashvili, Meryem Gülfem Öner, Özge Canli, Makoto Mark Taketo, Arun K. Mankan, Andrew C. Larner, Paul K. Ziegler, Thomas Reinheckel, Susanna Müller, Nina Müller, Dagmar Wirth, Tracy L Putoczki, Julia Slotta-Huspenina, Thomas Kirchner, Matthias Ernst, Florian R. Greten, Winfried S. Wels, Josef Müller-Höcker, Stefan Dröse, Michaela A. Diamanti, Thomas Korn, Tim F. Greten
Publikováno v:
Cell. 174(1)
In colorectal cancer patients, a high density of cytotoxic CD8+ T cells in tumors is associated with better prognosis. Using a Stat3 loss-of-function approach in two wnt/β-catenin-dependent autochthonous models of sporadic intestinal tumorigenesis,
Autor:
Ali Raza, Vidisha Raje, Jennifer Sisler, Marc Cantwell, Claudia Mertens, Heinz Baumann, Peter E. Shaw, Erin Tracy, Dipankar Bandyopadhyay, Andrew C. Larner, Jeremy Meier, Suzana Gispert, Moonjung Hyun, Kazuaki Takabe, Sylvia Torres-Odio
Publikováno v:
Science signaling. 10(472)
Signal transducer and activator of transcription 3 (STAT3) is associated with various physiological and pathological functions, mainly as a transcription factor that translocates to the nucleus upon tyrosine phosphorylation induced by cytokine stimul
Autor:
Andrew C. Larner, Jeremy Meier
Publikováno v:
Seminars in Immunology. 26:20-28
Signal Transducers and Activators of Transcription (STATs) have been studied extensively and have been associated with virtually every biochemical pathway. Until recently, however, they were thought to exert these effects solely as a nuclear transcri
Autor:
Andrew C. Larner, Qifang Zhang, Adly Yacoub, Vidisha Raje, Hossein A. Hamed, Paul Dent, Vasily A. Yakovlev, Marta Derecka, Qun Chen, Kristoffer Valerie, Ying Hu, Jeremy Meier, Edward J. Lesnefsky, Jennifer Sisler, Karol Szczepanek
Publikováno v:
Journal of Biological Chemistry. 288:31280-31288
Signal transducer and activator of transcription 3 (Stat3) is a key mediator in the development of many cancers. For 20 years, it has been assumed that Stat3 mediates its biological activities as a nuclear localized transcription factor activated by
Publikováno v:
Mitochondrion. 12:180-189
The down regulation of mitochondrial electron transport is an emerging mechanism of cytoprotective intervention that is effective in pathologic settings such as myocardial ischemia and reperfusion when the continuation of mitochondrial respiration pr
Autor:
Besim Ogretmen, Paul Dent, Andrew C. Larner, Roland Reinehr, Steven Grant, Paul B. Fisher, Clint Mitchell, Jeremy C. Allegood, Sarah Spiegel, Christina Voelkel-Johnson, Dieter Häussinger, Guo Zhang, Adly Yacoub, Margaret A. Park
Publikováno v:
Cancer Research. 70:6313-6324
The targeted therapeutics sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by activating CD95, and this drug combination is entering phase I evaluation. In this study, we determined how CD95 is activated by treatment