Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Andrew C. Jamieson"'
Publikováno v:
Molecular Therapy. 18(5):947-954
Hepatitis B virus (HBV) chronically infects 350-400 million people worldwide and causes1 million deaths yearly. Current therapies prevent new viral genome formation, but do not target pre-existing viral genomic DNA, thus curing only approximately 1/2
Autor:
Amelia Black, Alan Korman, Trevor Collingwood, Yuanyue Zhou, Casey C. Case, Yann Jouvenot, Barrett K. Fallentine, Edward J. Rebar, Xiaohong Zhong, Yanhong Kong, Karla Ann Henning, Victor Bartsevich, Lei Zhang, Andreas Reik, Lyndon Warfe, Philip D. Gregory, Andrew C. Jamieson, David John King, Xiao-Yong Li
Publikováno v:
Biotechnology and Bioengineering. 97:1180-1189
Increasing the yield of therapeutic proteins from mammalian production cell lines reduces costs and decreases the time to market. To this end, we engineered a zinc finger protein transcription factor (ZFP TF) that binds a DNA sequence within the prom
Autor:
Andrew C Jamieson
Publikováno v:
Obesity Surgery. 16:1400-1404
Autor:
Michael C. Holmes, Jeffrey C. Miller, Ya-Li Lee, Jeremy M. Rock, Sheldon Augustus, Philip D. Gregory, Fyodor D. Urnov, Christian Beauséjour, Matthew H. Porteus, Andrew C. Jamieson
Publikováno v:
Nature. 435:646-651
Permanent modification of the human genome in vivo is impractical owing to the low frequency of homologous recombination in human cells, a fact that hampers biomedical research and progress towards safe and effective gene therapy. Here we report a ge
Publikováno v:
Nature Reviews Drug Discovery. 2:361-368
Zinc-finger proteins (ZFPs) that recognize novel DNA sequences are the basis of a powerful technology platform with many uses in drug discovery and therapeutics. These proteins have been used as the DNA-binding domains of novel transcription factors
Autor:
Andrew C. Jamieson, Lei Zhang, Casey C. Case, Reed Hickey, David F. Meoli, Anjali K. Nath, Frank J. Giordano, Bingliang Chen, Edward J. Rebar, Yan Huang, Lei Xu, S. Kaye Spratt, Alan P. Wolffe, Yuxin Liang, Sameer K. Nath
Publikováno v:
Nature Medicine. 8:1427-1432
The relationship between the structure of zinc-finger protein (ZFP) transcription factors and DNA sequence binding specificity has been extensively studied. Advances in this field have made it possible to design ZFPs de novo that will bind to specifi
Autor:
Andrew C Jamieson
Publikováno v:
Obesity Surgery. 12:5-9
Autor:
Stephen P. Eisenberg, S. Kaye Spratt, Alan P. Wolffe, Andrew C. Jamieson, Matthew C. Mendel, Pei-Xiang Li, Qiang Liu, Yuxin Liang, Lei Zhang, Bingliang Chen, Xiaohong Zhong, Pei-Qi Liu, Hong Qi, Casey C. Case, Edward J. Rebar, Ya-Li Lee
Publikováno v:
Journal of Biological Chemistry. 276:11323-11334
We have mapped conserved regions of enhanced DNase I accessibility within the endogenous chromosomal locus of vascular endothelial growth factor A (VEGF-A). Synthetic zinc finger protein (ZFP) transcription factors were designed to target DNA sequenc
Autor:
Lei Zhang, Brian H. Johnstone, Edward J. Rebar, S. Kaye Spratt, Alan P. Wolffe, Eva Raschke, Hong Qi, Qiang Liu, Casey C. Case, Andrew C. Jamieson
Publikováno v:
Journal of Biological Chemistry. 275:33850-33860
We have targeted the activation of an endogenous chromosomal locus including the human erythropoietin gene using synthetic transcription factors. These transcription factors are targeted to particular DNA sequences in the 5′-flanking region of the
Publikováno v:
Proceedings of the National Academy of Sciences. 93:12834-12839
We have used two monovalent phage display libraries containing variants of the Zif268 DNA-binding domain to obtain families of zinc fingers that bind to alterations in the last 4 bp of the DNA sequence of the Zif268 consensus operator, GCG TG GGCG .