Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrew C. Goodrich"'
Publikováno v:
Journal of Biological Chemistry. 292:10002-10013
Nonribosomal peptide synthesis involves the interplay between covalent protein modifications, conformational fluctuations, catalysis, and transient protein-protein interactions. Delineating the mechanisms involved in orchestrating these various proce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa8e04383bce4879910107a19de29d9
https://doi.org/10.1074/jbc.m116.766220
https://doi.org/10.1074/jbc.m116.766220
Autor:
Valarie Del Rio, Tiffany A. Lu, P Rogelio Escamilla, James F. Reuther, Eric V. Anslyn, Bryan William Davies, Andrew C. Goodrich
Publikováno v:
Journal of the American Chemical Society. 140(10)
Peptide oligomers offer versatile scaffolds for the formation of potent antimicrobial agents due to their high sequence versatility, inherent biocompatibility, and chemical tunability. Though many methods exist for the formation of peptide-based macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2710ab1916a47a0597cd3648460d922f
https://pubmed.ncbi.nlm.nih.gov/29466660
https://pubmed.ncbi.nlm.nih.gov/29466660
Publikováno v:
Journal of the American Chemical Society. 137(37)
Nonribosomal peptide synthetases (NRPSs) are microbial enzymes that produce a wealth of important natural products by condensing substrates in an assembly line manner. The proper sequence of substrates is obtained by tethering them to phosphopantethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4be11faa681b14468dedd6781a62cd2
https://pubmed.ncbi.nlm.nih.gov/26334259
https://pubmed.ncbi.nlm.nih.gov/26334259
Autor:
Andrew C. Goodrich, Dominique P. Frueh
Publikováno v:
Biochemistry. 54(5)
Carrier proteins (CPs) play a central role in nonribosomal peptide synthetases (NRPSs) as they shuttle covalently attached substrates between active sites. Understanding how the covalent attachment of a substrate (loading) influences the molecular pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02c23d6d764739b5904028483a3dc74
https://pubmed.ncbi.nlm.nih.gov/25620398
https://pubmed.ncbi.nlm.nih.gov/25620398
Publikováno v:
Current opinion in structural biology. 23(5)
NMR structural studies of large monomeric and multimeric proteins face distinct challenges. In large monomeric proteins, the common occurrence of frequency degeneracies between residues impedes unambiguous assignment of NMR signals. To overcome this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b253b8b2ce344a5c8a6e65e6e7446de
https://pubmed.ncbi.nlm.nih.gov/23850141
https://pubmed.ncbi.nlm.nih.gov/23850141
Autor:
Dominique P. Frueh, Andrew C. Goodrich, Bradley J. Harden, Subrata H. Mishra, Scott R. Nichols
Publikováno v:
Biophysical Journal. 108:58a
Nonribosomal peptide synthetases (NRPSs) are modular, multi-domain, enzymatic assembly lines that combine simple substrates to synthesize complex natural products (e.g. penicillin, bacitracin, yersiniabactin). Substrates are each covalently attached
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76fd404f25fa8f18180ce172f929897
https://doi.org/10.1016/j.bpj.2014.11.352
https://doi.org/10.1016/j.bpj.2014.11.352
Autor:
Andrew C. Goodrich, Bradley J. Harden, Dominique P. Frueh, Scott R. Nichols, Subrata H. Mishra
Publikováno v:
Biophysical Journal. (2):180a
Non-ribosomal peptide synthetases (NRPSs) are enzymatic systems that synthesize important natural products in bacteria and fungi, often with pharmaceutical applications (antibiotics, antitumor agents or immunosuppressants). NRPSs use a series of doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1779cedc9cf9570f0343bc572b6a92b6
Autor:
Andrew C. Goodrich, Dominique P. Frueh
Publikováno v:
Biophysical Journal. (2):510a
Nonribosomal peptide synthetases (NRPSs) are modular enzymatic systems responsible for the production of complex secondary metabolites in bacteria and fungi. Each module is comprised of (at least) three core domains whose combined action leads to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5f25fdc12b8f7be08b83e45f6fa466
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