Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Andrew C. Giles"'
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102262- (2023)
Summary: We present an optimized protocol for in vivo affinity purification proteomics and biochemistry using the model organism C. elegans. We describe steps for target tagging, large-scale culture, affinity purification using a cryomill, mass spect
Externí odkaz:
https://doaj.org/article/acf1d37cb8a8430295a9b861fd294ed7
Autor:
Andrew C. Giles, Brock Grill
Publikováno v:
Neural Development, Vol 15, Iss 1, Pp 1-18 (2020)
Abstract Huwe1 is a highly conserved member of the HECT E3 ubiquitin ligase family. Here, we explore the growing importance of Huwe1 in nervous system development, function and disease. We discuss extensive progress made in deciphering how Huwe1 regu
Externí odkaz:
https://doaj.org/article/e68e07dfc0af41538e017ad16fba4d2b
Autor:
Oliver Crawley, Karla J. Opperman, Muriel Desbois, Isabel Adrados, Melissa A. Borgen, Andrew C. Giles, Derek R. Duckett, Brock Grill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Despite growing interest in the role of autophagy in neurons, it remains unclear how this process is regulated, in particular, how autophagy is spatially restricted in subcellular compartments in neurons. In this study, the authors use an unbiased pr
Externí odkaz:
https://doaj.org/article/1df888c78b5d4bdb956fe12ca5196ab5
Publikováno v:
npj Science of Learning, Vol 2, Iss 1, Pp 1-10 (2017)
Habituation is more than learning to ignore The long held notion that habituation is simply learning to ignore a repeated stimulus has been challenged by this work showing that habituation reflects a shift in response strategy to escape a repeated av
Externí odkaz:
https://doaj.org/article/99b4bca11d8c434ba46f7c8a500007d0
Autor:
Karla J. Opperman, Ben Mulcahy, Andrew C. Giles, Monica G. Risley, Rayna L. Birnbaum, Erik D. Tulgren, Ken Dawson-Scully, Mei Zhen, Brock Grill
Publikováno v:
Cell Reports, Vol 19, Iss 4, Pp 822-835 (2017)
Genetic changes in the HECT ubiquitin ligase HUWE1 are associated with intellectual disability, but it remains unknown whether HUWE1 functions in post-mitotic neurons to affect circuit function. Using genetics, pharmacology, and electrophysiology, we
Externí odkaz:
https://doaj.org/article/e4065ad31e5e46b9893cfd813f650a47
Autor:
Brock Grill, Kirill A. Martemyanov, Andrew C. Giles, Brian S. Muntean, Maria Dao, Dandan Wang
Publikováno v:
Human Molecular Genetics. 31:510-522
GNAO1 encephalopathy is a neurodevelopmental disorder with a spectrum of symptoms that include dystonic movements, seizures and developmental delay. While numerous GNAO1 mutations are associated with this disorder, the functional consequences of path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39256787f25f7c6c679e52dffafc298
https://doi.org/10.1093/hmg/ddab235
https://doi.org/10.1093/hmg/ddab235
Autor:
Ikue Mori, Wagner Steuer Costa, Shunji Nakano, Linghuan Xu, Andrew C. Giles, Alexander Gottschalk, Muneki Ikeda
Publikováno v:
Proceedings of the National Academy of Sciences. 117:6178-6188
The nervous system evaluates environmental cues and adjusts motor output to ensure navigation toward a preferred environment. The nematode Caenorhabditis elegans navigates in the thermal environment and migrates toward its cultivation temperature by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1a7a171dc854928452ea09f8285f73d
https://doi.org/10.1073/pnas.1918528117
https://doi.org/10.1073/pnas.1918528117
Autor:
Melissa A. Borgen, Oliver Crawley, Brock Grill, Karla J. Opperman, Muriel Desbois, Isabel Adrados, Andrew C. Giles, Derek R. Duckett
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Autophagy is an intracellular catabolic process prominent in starvation, aging and disease. Neuronal autophagy is particularly important, as it affects the development and function of the nervous system, and is heavily implicated in neurodegenerative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23fc4fbb497504dd4a60ee4a3fde192e
http://link.springer.com/article/10.1038/s41467-019-12804-3
http://link.springer.com/article/10.1038/s41467-019-12804-3
Autor:
Andrew C. Giles, Caitlin Johnston, Ikuo Masuho, Kirill A. Martemyanov, Stefano Zucca, Erik A. Lundquist, Brock Grill, Maria Dao, Hannah M. Stoveken, Matthew S. Gill, Dandan Wang, Chenghui Song, Cesare Orlandi, Karla J. Opperman
Publikováno v:
Science. 365:1267-1273
Worms yield opioid receptor insight The µ-opioid receptor (MOR) is the target of pain-reducing drugs, including morphine and the potent synthetic opioid fentanyl. Better understanding of the receptor system is needed to suppress potentially deadly s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d746d65c4ff3117ff179798dd525944f
https://doi.org/10.1126/science.aau2078
https://doi.org/10.1126/science.aau2078
Autor:
Nycole Maza, Dandan Wang, Cody Kowalski, Hannah M. Stoveken, Maria Dao, Omar K. Sial, Andrew C. Giles, Brock Grill, Kirill A. Martemyanov
Publikováno v:
Nat Neurosci
Repeated exposure to opioids causes tolerance, which limits their analgesic utility and contributes to overdose and abuse liability. However, the molecular mechanisms underpinning tolerance are not well understood. Here, we used a forward genetic scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c791988382102fdaade06a449574af4
https://pubmed.ncbi.nlm.nih.gov/35982154
https://pubmed.ncbi.nlm.nih.gov/35982154