Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Andrew C. G. Porter"'
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Imperfect conservation of human pre-mRNA splice sites is necessary to produce alternative isoforms. This flexibility is combined with the precision of the message reading frame. Apart from intron-termini GU_AG and the branchpoint A, the most conserve
Externí odkaz:
https://doaj.org/article/7e98d89c673344a2a9382a3c8b41de6e
Publikováno v:
International Journal of Molecular Sciences
Type II topoisomerase enzymes are essential for resolving DNA topology problems arising through various aspects of DNA metabolism. In vertebrates two isoforms are present, one of which (TOP2A) accumulates on chromatin during mitosis. Moreover, TOP2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d5cbb0c84fe03f30f5dc05176511ae6
https://pubmed.ncbi.nlm.nih.gov/30871006
https://pubmed.ncbi.nlm.nih.gov/30871006
Publikováno v:
The journal of gene medicine. 16(1-2)
Mutations in the β-globin gene (HBB) cause haemoglobinopathies where current treatments have serious limitations. Gene correction by homologous recombination (HR) is an attractive approach to gene therapy for such diseases and is stimulated by gene-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2fce2cffdb16cb45b20a7ef1a45dd26
https://pubmed.ncbi.nlm.nih.gov/24590875
https://pubmed.ncbi.nlm.nih.gov/24590875
Autor:
Christine J, Farr, Melissa, Antoniou-Kourounioti, Michael L, Mimmack, Arsen, Volkov, Andrew C G, Porter
Publikováno v:
Nucleic Acids Research
As proliferating cells transit from interphase into M-phase, chromatin undergoes extensive reorganization, and topoisomerase (topo) IIα, the major isoform of this enzyme present in cycling vertebrate cells, plays a key role in this process. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ae089e9c2e22c9b6eb4998785d48d57
https://pubmed.ncbi.nlm.nih.gov/24476913
https://pubmed.ncbi.nlm.nih.gov/24476913
Publikováno v:
European Journal of Biochemistry. 268:1605-1612
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47a2f4b822a617bf56f867906499643
https://doi.org/10.1046/j.1432-1033.2001.02027.x
https://doi.org/10.1046/j.1432-1033.2001.02027.x
Autor:
Andrew C G, Porter
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 582
Eukaryotic type II topoisomerases (Topo II) are implicated in a wide range of cellular processes. Cells in which Topo II protein has been specifically depleted or mutated provide powerful systems for analysing the normal in vivo functions of Topo II
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de2e6d57142e1c145b5ffe3efbd812cb
https://pubmed.ncbi.nlm.nih.gov/19763955
https://pubmed.ncbi.nlm.nih.gov/19763955
Autor:
Olga Isman, Michael Roberts, Jennifer Morgan, Ian R Graham, Kirsten Goldring, Diana J. Watt, Qilong Lu, Matthew G. Dunckley, Andrew C. G. Porter, Terence A. Partridge, George Dickson
Publikováno v:
Human Gene Therapy. :081015093227032
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f914a1dd10491a1739ef99eed192ae3b
https://doi.org/10.1089/hgt.2008.063
https://doi.org/10.1089/hgt.2008.063
Autor:
Dirk R. Gewert, Laurence E. Reid, Adrian H. Brasnett, Chris Gilbert, Ian M. Kerr, Andrew C. G. Porter, George R. Stark
Publikováno v:
Proceedings of the National Academy of Sciences. 86:840-844
Genomic and cDNA clones corresponding to 9-27, a member of the human 1-8 gene family highly inducible by alpha- and gamma-interferons (IFNs), have been isolated and characterized. A 1.7-kilobase genomic clone contains a complete functional gene with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c55235a8d4bb2e8c7a66a5b30c1b38a4
https://doi.org/10.1073/pnas.86.3.840
https://doi.org/10.1073/pnas.86.3.840
Autor:
John Spencer Emtage, Andrew C. G. Porter, M. A. Easton, Michael Houghton, H. M. Lewis, John C. Smith, S.M. Doel, Norman Henry Carey, G. H. Catlin, A. G. Stewart, T.P. Patel
Publikováno v:
Nucleic acids research. 8(13)
Using synthetic oligodeoxyribonucleotides to prime the transcription of interferon mRNA and cDNA, we recently determined the mRNA sequence coding for the 47 amino-terminal amino acids of mature human fibroblast interferon (1). From this sequence, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690f4cda120518c0d2da067aeeb2af30
https://pubmed.ncbi.nlm.nih.gov/6159580
https://pubmed.ncbi.nlm.nih.gov/6159580