Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Andrew C. Eliot"'
1
Fosmidomycin biosynthesis diverges from related phosphonate natural products
Autor: Annette Erb, Elizabeth I. Parkinson, Andrew C. Eliot, Kou San Ju, William W. Metcalf
Publikováno v: Nature chemical biology
Fosmidomycin and related molecules comprise a family of phosphonate natural products with potent antibacterial, antimalarial and herbicidal activities. To understand the biosynthesis of these compounds, we characterized the fosmidomycin producer, Str
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0953733c401ce9448babf5aa0ddb6f
https://doi.org/10.1038/s41589-019-0343-1
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2
Molecular Cloning and Heterologous Expression of the Dehydrophos Biosynthetic Gene Cluster
Autor: Wilfred A. van der Donk, Benjamin T. Circello, William W. Metcalf, Andrew C. Eliot, Jin Hee Lee
Publikováno v: Chemistry & Biology. 17(4):402-411
Dehydrophos is a vinyl phosphonate tripeptide produced by Streptomyces luridus with demonstrated broad spectrum antibiotic activity. To identify genes necessary for biosynthesis of this unusual compound we screened a fosmid library of S. luridus for
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3
Biosynthesis of 2-Hydroxyethylphosphonate, an Unexpected Intermediate Common to Multiple Phosphonate Biosynthetic Pathways
Autor: Benjamin T. Circello, Joshua A. V. Blodgett, Wilfred A. van der Donk, Andrew C. Eliot, Zengyi Shao, Gongyong Li, Huimin Zhao, Ryan Woodyer, William W. Metcalf
Publikováno v: Journal of Biological Chemistry. 283:23161-23168
Phosphonic acids encompass a common yet chemically diverse class of natural products that often possess potent biological activities. Here we report that, despite the significant structural differences among many of these compounds, their biosyntheti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e11d624bf699db90affea9eff3ad7e
https://doi.org/10.1074/jbc.m801788200
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6
Structure of 1-aminocyclopropane-1-carboxylate synthase in complex with an amino-oxy analogue of the substrate: implications for substrate binding
Autor: Andrew C. Eliot, Guido Capitani, Radii M. Khomutov, Heinz Gut, Markus G. Grütter, Jack F. Kirsch
Publikováno v: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1647:55-60
The crystal structure of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with the substrate analogue [2-(amino-oxy)ethyl](5′-deoxyadenosin-5′-yl)(methyl)sulfonium (AMA) was determined at 2.01-A resolution. The crystallographic results
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dafc1ed89d53a8be5c4eee794ca9bc
https://doi.org/10.1016/s1570-9639(03)00049-9
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7
Modulation of the Internal Aldimine pKa's of 1-Aminocyclopropane-1-carboxylate Synthase and Aspartate Aminotransferase by Specific Active Site Residues
Autor: Andrew C. Eliot, Jack F. Kirsch
Publikováno v: Biochemistry. 41:3836-3842
The active sites of the homologous pyridoxal phosphate- (PLP-) dependent enzymes 1 -aminocyclopropane- I -carboxylate (ACC) synthase and aspartate aminotransferase (AATase) are almost entirely conserved, yet the pK a 's ofthe two internal aldimines a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7496af05539de15360f8e8111a313602
https://doi.org/10.1021/bi016084l
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8
Cofactor Requirements and Reconstitution Of Microcin B17 Synthetase: A Multienzyme Complex that Catalyzes the Formation of Oxazoles and Thiazoles in the Antibiotic Microcin B17
Autor: Christopher T. Walsh, Andrew C. Eliot, Ranabir Sinha Roy, Bryce E. Nickels, Neil L. Kelleher, Jill C. Milne, Anita Wokhlu
Publikováno v: Biochemistry. 38:4768-4781
In the maturation of the Escherichia coli antibiotic Microcin B17 (MccB17), the McbA prepro-antibiotic is modified post-translationally by the multimeric microcin synthetase complex (composed of the McbB, -C, and -D proteins), which cyclizes four cys
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30c9f8f970a91736baf01ece26081e5
https://doi.org/10.1021/bi982975q
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9
ATP/GTP Hydrolysis Is Required for Oxazole and Thiazole Biosynthesis in the Peptide Antibiotic Microcin B17
Autor: Christopher T. Walsh, Neil L. Kelleher, Andrew C. Eliot, Jill C. Milne
Publikováno v: Biochemistry. 37:13250-13261
In the maturation of the Escherichia coli antibiotic Microcin B17, the product of the mcbA gene is modified posttranslationally by the multimeric Microcin synthetase complex (composed of McbB, C, and D) to cyclize four Cys and four Ser residues to fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef064894d80c3c673b266ca19a6308f
https://doi.org/10.1021/bi980996e
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