Výsledky vyhledávání - "Andrew C. Bell"

Inhibition of non-homologous end joining in Fanconi Anemia cells results in rescue of survival after interstrand crosslinks but sensitization to replication associated double-strand breaks

Autor: Simon N. Powell, Andrew C. Bell, Laura J. Eccles

Publikováno v: DNA Repair. 64:1-9

When Fanconi Anemia (FA) proteins were depleted in human U2OS cells with integrated DNA repair reporters, we observed decreases in homologous recombination (HR), decreases in mutagenic non-homologous end joining (m-NHEJ) and increases in canonical NH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c3013fc08a3966ac3d26e3eef1172e9
https://doi.org/10.1016/j.dnarep.2018.02.003

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Outcomes of multimodal therapy in a large series of patients with anaplastic thyroid cancer

Autor: Jennifer Ma, Jonathan E. Leeman, Kyrie S. Olsen, Ian Ganly, Nancy Y. Lee, Eric J. Sherman, Andries H. Groen, Andrew C. Bell, Ashok R. Shaha, Benjamin H. Lok, Nadeem Riaz, Sean McBride, Jung Julie Kang, C. Jillian Tsai, E.S. Anderson, Dan Fan

Publikováno v: Cancer. Wiley

Background The role of radiotherapy (RT) in the treatment of patients with anaplastic thyroid cancer (ATC) for local tumor control is critical because mortality often is secondary to complications of tumor volume rather than metastatic disease. Herei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e4f8927304670689195326493f3c3b
https://research.rug.nl/en/publications/3e02e42d-de33-488b-9a56-1b847a3b0cb5

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Human papillomavirus 16 promotes microhomology-mediated end-joining

Autor: Andrew C. Bell, Nadeem Riaz, Pedro Blecua, Rahul Majumdar, Himanshi Narang, Rama Rao Damerla, Suleman S. Hussain, Pavithran T. Ravindran, Daniel S. Higginson, Xiaoqing Rong-Mullins, Nancy Y. Lee, Simon N. Powell, Yi Li, Jonathan E. Leeman

Squamous cell carcinomas (SCCs) arising from aerodigestive or anogenital epithelium that are associated with the human papillomavirus (HPV) are far more readily cured with radiation therapy than HPV-negative SCCs. The mechanism behind this increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369eb1da4cd5880bdfc499d7e9412463
https://europepmc.org/articles/PMC6815166/

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Proton Radiotherapy for Recurrent or Metastatic Head and Neck Cancers with Palliative Quad Shot

Autor: Marina Shcherba, Nancy Y. Lee, Oren Cahlon, Xin Cai, Jennifer Ma, Jingfeng Zong, Han Xiao, Benjamin H. Lok, Nadeem Riaz, Sean McBride, Andrew C. Bell, Chiaojung Jillian Tsai, Eric J Sherman, Stanley I. Gutiontov

Publikováno v: International journal of particle therapy. 4(4)

Purpose: Some patients with previously treated, unresectable, recurrent or metastatic head and neck malignancies are not amenable to curative-intent treatment. Here, we investigated the quad-shot (RTOG 8502) regimen of hypofractionated proton radioth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c5691b0e41ceae1d4750c8d2fab23a
https://pubmed.ncbi.nlm.nih.gov/30246055

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Talazoparib Is a Potent Radiosensitizer in Small Cell Lung Cancer Cell Lines and Xenografts

Autor: Benjamin H. Lok, Elisa de Stanchina, Andrew C. Bell, John T. Poirier, Jennifer Ma, James Laird, Charles M. Rudin

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 24(20)

Purpose: Small cell lung cancer (SCLC) is an aggressive malignancy with a critical need for novel therapies. Our goal was to determine whether PARP inhibition could sensitize SCLC cells to ionizing radiation (IR) and if so, to determine the contribut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b2d098e7c2489f49c07158cc74e1758
https://pubmed.ncbi.nlm.nih.gov/29945991

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Radiotherapy to demonstrate persistent overall survival benefit in locally advanced or metastatic anaplastic thyroid cancer

Autor: Eric J. Sherman, Ian Ganly, Benjamin H. Lok, E.S. Anderson, Nadeem Riaz, Ashok R. Shaha, Nancy Y. Lee, Andrew C. Bell, Sean McBride, C. Jillian Tsai, Jennifer Ma, Jonathan E. Leeman

Publikováno v: Journal of Clinical Oncology. 36:e18115-e18115

e18115Background: Anaplastic thyroid cancer (ATC) is associated with poor prognosis and rapid tumor enlargement which affects nearby critical structures. Mortality is often secondary to complicatio...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a48a19aa63f23d6129d0d080446da194
https://doi.org/10.1200/jco.2018.36.15_suppl.e18115

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