Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Andrew C. Adams"'
Autor:
Jo E. Lewis, Chloe Monnier, Hayley Marshall, Maxine Fowler, Rebecca Green, Scott Cooper, Aristeidis Chiotellis, Jeni Luckett, Alan C. Perkins, Tamer Coskun, Andrew C. Adams, Ricardo J. Samms, Francis J.P. Ebling, Kostas Tsintzas
Publikováno v:
Molecular Metabolism, Vol 31, Iss , Pp 45-54 (2020)
Objective: Fibroblast growth factor 21 (FGF21) has been shown to rapidly lower body weight in the Siberian hamster, a preclinical model of adiposity. This induced negative energy balance mediated by FGF21 is associated with both lowered caloric intak
Externí odkaz:
https://doaj.org/article/a1e9dc6506f942278c9fc2ad5c935b3a
Autor:
Patrick J. Antonellis, Brian A. Droz, Richard Cosgrove, Libbey S. O'Farrell, Tamer Coskun, James W. Perfield, II, Steven Bauer, Mark Wade, Tara E. Chouinard, Joseph T. Brozinick, Andrew C. Adams, Ricardo J. Samms
Publikováno v:
Molecular Metabolism, Vol 30, Iss , Pp 131-139 (2019)
Objective: Fibroblast growth factor 19 (FGF19) is a postprandial hormone which plays diverse roles in the regulation of bile acid, glucose, and lipid metabolism. Administration of FGF19 to obese/diabetic mice lowers body weight, improves insulin sens
Externí odkaz:
https://doaj.org/article/f1ef67a9a6a44312b87faed6aa256893
Autor:
Kacey J. Prentice, Stacy G. Wendell, Ying Liu, Judith A. Eversley, Sonia R. Salvatore, Haneesha Mohan, Sydney L. Brandt, Andrew C. Adams, X. Serena Wang, David Wei, Garret A. FitzGerald, Timothy B. Durham, Craig D. Hammond, Kyle W. Sloop, Carsten Skarke, Francisco J. Schopfer, Michael B. Wheeler
Publikováno v:
EBioMedicine, Vol 27, Iss C, Pp 200-213 (2018)
Prescription ω-3 fatty acid ethyl ester supplements are commonly used for the treatment of hypertriglyceridemia. However, the metabolic profile and effect of the metabolites formed by these treatments remain unknown. Here we utilized unbiased metabo
Externí odkaz:
https://doaj.org/article/8859af43754d46f59999fc8b6184ede4
Autor:
Bhavna N. Desai, Garima Singhal, Mikiko Watanabe, Darko Stevanovic, Thomas Lundasen, ffolliott M. Fisher, Marie L. Mather, Hilde G. Vardeh, Nicholas Douris, Andrew C. Adams, Imad A. Nasser, Garret A. FitzGerald, Jeffrey S. Flier, Carsten Skarke, Eleftheria Maratos-Flier
Publikováno v:
Molecular Metabolism, Vol 6, Iss 11, Pp 1395-1406 (2017)
Objective: Excess ethanol consumption has serious pathologic consequences. In humans, repeated episodes of binge drinking can lead to liver damage and have adverse effects on other organs such as pancreas and brain. Long term chronic consumption of e
Externí odkaz:
https://doaj.org/article/46986f70a5ac4562857f1b01835bbf14
Autor:
Jo E. Lewis, Ricardo J. Samms, Scott Cooper, Jeni C. Luckett, Alan C. Perkins, Andrew C. Adams, Kostas Tsintzas, Francis J. P. Ebling
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract FGF21 exerts profound metabolic effects in Siberian hamsters exposed to long day (LD) photoperiods that increase appetite and adiposity, however these effects are attenuated in short day (SD) animals that display hypophagia and reduced adipo
Externí odkaz:
https://doaj.org/article/95e972ce73d34b99befdbcf40d02600f
Autor:
Garima Singhal, Nicholas Douris, Alan J. Fish, Xinyao Zhang, Andrew C. Adams, Jeffrey S. Flier, Pavlos Pissios, Eleftheria Maratos-Flier
Publikováno v:
Molecular Metabolism, Vol 5, Iss 8, Pp 690-698 (2016)
Objective: Reproduction is an energetically expensive process. Insufficient calorie reserves, signaled to the brain through peripheral signals such as leptin, suppress fertility. Recently, fibroblast growth factor 21 (FGF21) was implicated as a signa
Externí odkaz:
https://doaj.org/article/bcee5f6c8954400ab1b0fa49f042571f
Autor:
Ricardo J. Samms, Dennis P. Smith, Christine C. Cheng, Patrick P. Antonellis, James W. Perfield 2nd, Alexei Kharitonenkov, Ruth E. Gimeno, Andrew C. Adams
Publikováno v:
Cell Reports, Vol 11, Iss 7, Pp 991-999 (2015)
A primary target of the pleiotropic metabolic hormone FGF21 is adipose tissue, where it initiates a gene expression program to enhance energy expenditure, an effect presumed to be centered on augmented UCP1 expression and activity. In UCP1 null (UCP1
Externí odkaz:
https://doaj.org/article/3d27427d33034b5a8636289a607e3145
Autor:
Ricardo J. Samms, Christine C. Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, Andrew. C. Adams, Muhammad A. Abdul-Ghani, Ralph A. DeFronzo, Luke Norton
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 323(2)
Fibroblast growth factor 21 (FGF21) is increased acutely by carbohydrate ingestion and is elevated in patients with type 2 diabetes (T2D). However, the physiological significance of increased FGF21 in humans remains largely unknown. We examined wheth
Autor:
Guannan Li, Hanqing Chen, Feng Shen, Steven Blake Smithson, Gavyn Lee Shealy, Qinggong Ping, Zerong Liang, Jingyan Han, Andrew C. Adams, Yu Li, Dechun Feng, Bin Gao, Masahiro Morita, Xianlin Han, Tim H. Huang, Nicolas Musi, Mengwei Zang
Publikováno v:
Hepatology.
Autor:
Jack Knorr, Russell Perry, Peter Chen, Corey Hebert, Richard E. Higgs, Mark D. Williams, Joseph Boscia, Bharat Mocherla, Masoud Azizad, Princy Kumar, Robert L. Gottlieb, Paul Klekotka, Dipak R. Patel, Ajay Nirula, Imad Shawa, Andra L. Blomkalns, Andrew C. Adams, Gregory D. Huhn, Kenneth L. Custer, Lei Shen, Timothy R. Holzer, Jason Morris, Philip J. Ebert, Andrew E. Schade, Jacob Van Naarden, Blaze investigators, Gerard J. Oakley, Jose Cardona, Janelle Sabo, Matan C. Dabora, Daniel Skovronsky, Chad Crystal, Barry Heller, Awawu Igbinadolor, Michael Dougan
Publikováno v:
Clinical Infectious Diseases. 75:e440-e449
Background Based on interim analyses and modeling data, lower doses of bamlanivimab and etesevimab together (700/1400 mg) were investigated to determine optimal dose and expand availability of treatment. Methods This Phase 3 portion of the BLAZE-1 tr