Zobrazeno 1 - 10
of 135
pro vyhledávání: '"Andrew C. Kruse"'
Autor:
Katherine J. Susa, Gary A. Bradshaw, Robyn J. Eisert, Charlotte M. Schilling, Marian Kalocsay, Stephen C. Blacklow, Andrew C. Kruse
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114332- (2024)
Summary: The B cell receptor (BCR) signals together with a multi-component co-receptor complex to initiate B cell activation in response to antigen binding. Here, we take advantage of peroxidase-catalyzed proximity labeling combined with quantitative
Externí odkaz:
https://doaj.org/article/1216f0b2527b47618886cbc540d72911
Autor:
Irina Shlosman, Elayne M. Fivenson, Morgan S. A. Gilman, Tyler A. Sisley, Suzanne Walker, Thomas G. Bernhardt, Andrew C. Kruse, Joseph J. Loparo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The peptidoglycan (PG) cell wall protects bacteria against osmotic lysis and determines cell shape, making this structure a key antibiotic target. Peptidoglycan is a polymer of glycan chains connected by peptide crosslinks, and its synthesis
Externí odkaz:
https://doaj.org/article/46f4aabe611d4823be2a46c4d4c0f829
Autor:
Edward P. Harvey, Jung-Eun Shin, Meredith A. Skiba, Genevieve R. Nemeth, Joseph D. Hurley, Alon Wellner, Ada Y. Shaw, Victor G. Miranda, Joseph K. Min, Chang C. Liu, Debora S. Marks, Andrew C. Kruse
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Off-target binding hinders the development of therapeutic antibodies and reproducibility in basic research settings. Here the authors develop a method to quantify and reduce the polyreactivity of antibody fragments based on protein sequence alone.
Externí odkaz:
https://doaj.org/article/9f15c88fe2344995bf186f5732b9be87
Autor:
Qi Li, Fiachra Humphries, Roxie C. Girardin, Aaron Wallace, Monir Ejemel, Alla Amcheslavsky, Conor T. McMahon, Zachary A. Schiller, Zepei Ma, John Cruz, Alan P. Dupuis, Anne F. Payne, Arooma Maryam, Nese Kurt Yilmaz, Kathleen A. McDonough, Brian G. Pierce, Celia A. Schiffer, Andrew C. Kruse, Mark S. Klempner, Lisa A. Cavacini, Katherine A. Fitzgerald, Yang Wang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Anti-COVID antibody therapeutics have been developed but not widely used due to their high cost and escape of neutralization from the emerging variants. Here, we describe the development of VHH-IgA1.1, a nanobody IgA fusion molecule as an inhalable,
Externí odkaz:
https://doaj.org/article/daf01ec763884ddfa115d5def03c2186
Autor:
Jung-Eun Shin, Adam J. Riesselman, Aaron W. Kollasch, Conor McMahon, Elana Simon, Chris Sander, Aashish Manglik, Andrew C. Kruse, Debora S. Marks
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The ability to design functional sequences is central to protein engineering and biotherapeutics. Here the authors introduce a deep generative alignment-free model for sequence design applied to highly variable regions and design and test a diverse n
Externí odkaz:
https://doaj.org/article/9f71edbc554b43bcb6739269e59cc88c
Autor:
Alla Amcheslavsky, Aaron L. Wallace, Monir Ejemel, Qi Li, Conor T. McMahon, Matteo Stoppato, Serena Giuntini, Zachary A. Schiller, Jessica R. Pondish, Jacqueline R. Toomey, Ryan M. Schneider, Jordan Meisinger, Raimond Heukers, Andrew C. Kruse, Eileen M. Barry, Brian G. Pierce, Mark S. Klempner, Lisa A. Cavacini, Yang Wang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Enterotoxigenic Escherichia coli (ETEC) is estimated to cause approximately 380,000 deaths annually during sporadic or epidemic outbreaks worldwide. Development of vaccines against ETEC is very challenging due to the vast heterogeneity of th
Externí odkaz:
https://doaj.org/article/8c71423749de4016b747f5338a446935
Autor:
Yongqiang Gao, Jeremy D. Amon, Lior Artzi, Fernando H. Ramírez-Guadiana, Kelly P. Brock, Joshua C. Cofsky, Deborah S. Marks, Andrew C. Kruse, David Z. Rudner
Publikováno v:
Science. 380:387-391
Bacterial spores resist antibiotics and sterilization and can remain metabolically inactive for decades, but they can rapidly germinate and resume growth in response to nutrients. Broadly conserved receptors embedded in the spore membrane detect nutr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8beb65bfa66f2dee85bee531e175a9
https://doi.org/10.1126/science.adg9829
https://doi.org/10.1126/science.adg9829
Autor:
Robert W. Malone, Philip Tisdall, Philip Fremont-Smith, Yongfeng Liu, Xi-Ping Huang, Kris M. White, Lisa Miorin, Elena Moreno, Assaf Alon, Elise Delaforge, Christopher D. Hennecker, Guanyu Wang, Joshua Pottel, Robert V. Blair, Chad J. Roy, Nora Smith, Julie M. Hall, Kevin M Tomera, Gideon Shapiro, Anthony Mittermaier, Andrew C. Kruse, Adolfo García-Sastre, Bryan L. Roth, Jill Glasspool-Malone, Darrell O. Ricke
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, there are no
Externí odkaz:
https://doaj.org/article/886e5d63bd85412f90473f81dc54eb9e
Publikováno v:
eLife, Vol 9 (2020)
CD81 and its binding partner CD19 are core subunits of the B cell co-receptor complex. While CD19 belongs to the extensively studied Ig superfamily, CD81 belongs to a poorly understood family of four-pass transmembrane proteins called tetraspanins. T
Externí odkaz:
https://doaj.org/article/3af7915df1a447b1b7c09ff919f4a7b7
Autor:
Sanduo Zheng, Andrew C Kruse
Publikováno v:
eLife, Vol 8 (2019)
Differences in the kinetics of G protein activation can explain why only some receptors can activate potassium ion channels called GIRKs.
Externí odkaz:
https://doaj.org/article/1b67e1c8dd5642e9b0f21a78cd57ba74