Nerve agent hydrolysis activity designed into a human drug metabolism enzyme.

Autor: Andrew C Hemmert, Tamara C Otto, Roberto A Chica, Monika Wierdl, Jonathan S Edwards, Steven M Lewis, Carol C Edwards, Lyudmila Tsurkan, C Linn Cadieux, Shane A Kasten, John R Cashman, Stephen L Mayo, Philip M Potter, Douglas M Cerasoli, Matthew R Redinbo

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e17441 (2011)

Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poison

Externí odkaz: https://doaj.org/article/cc3673771a9c4824bb65ae97a1dd1a81

First Report of bla VIM-4 - and mcr-9 -Coharboring Enterobacter Species Isolated from a Pediatric Patient

Autor: Michael J. Satlin, Barry N. Kreiswirth, Kalyan D. Chavda, Stephen G. Jenkins, Lars F. Westblade, Liang Chen, Andrew C. Hemmert, Mariana Castanheira

Publikováno v: mSphere, Vol 4, Iss 5, p e00629-19 (2019)
mSphere, Vol 4, Iss 5 (2019)

We describe the complete genome assembly and sequence of a clinical Enterobacter isolate harboring both bla VIM-4 and mcr-9 recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760fdc7f88b4c9707f67a2c986add18b
https://doi.org/10.1128/msphere.00629-19

Multicenter Evaluation of BioFire FilmArray Meningitis/Encephalitis Panel for Detection of Bacteria, Viruses, and Yeast in Cerebrospinal Fluid Specimens

Autor: Joan-Miquel Balada-Llasat, J. Kristie Johnson, Paul R. Lephart, Amy Leber, Jo Anne Miller, Paul C. Schreckenberger, Sharon L. Reed, Sarah Holt, Jennifer Dien Bard, Karen C. Carroll, Judy A. Daly, Sharon DesJarlais, Kimberle C. Chapin, Nicole L. Soliven, Jillian Cullison, Tori Enomoto, Matthew J. Bankowski, Kevin M. Bourzac, Andrew C. Hemmert, Lindsay LeBlanc, Javier Mestas, Kathy Everhart, Hossein Salimnia

Publikováno v: Journal of clinical microbiology, vol 54, iss 9
Leber, AL; Everhart, K; Balada-Llasat, JM; Cullison, J; Daly, J; Holt, S; et al.(2016). Multicenter evaluation of biofire filmarray meningitis/encephalitis panel for detection of bacteria, viruses, and yeast in cerebrospinal fluid specimens. Journal of Clinical Microbiology, 54(9), 2251-2261. doi: 10.1128/JCM.00730-16. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2cf1h55f

Rapid diagnosis and treatment of infectious meningitis and encephalitis are critical to minimize morbidity and mortality. Comprehensive testing of cerebrospinal fluid (CSF) often includes Gram stain, culture, antigen detection, and molecular methods,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ed8f333c4f209d675ffa0a93e9f2f8
https://escholarship.org/uc/item/2cf1h55f

Enhancing pathogen identification in patients with meningitis and a negative Gram stain using the BioFire FilmArray® Meningitis/Encephalitis panel

Autor: Rodrigo Hasbun, Elizabeth Aguilera, Susan H. Wootton, Lucrecia Salazar, Andrew C. Hemmert

Publikováno v: Annals of Clinical Microbiology and Antimicrobials

Background Meningitis with a negative cerebrospinal (CSF) Gram stain represents a diagnostic and therapeutic challenge. The purpose of our study was to evaluate the performance of the BioFire FilmArray® Meningitis/Encephalitis (FA ME) panel in patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2165971f3cc0aa5b081133422d2f499f
http://europepmc.org/articles/PMC4839114

Human Carboxylesterase 1 Stereoselectively Binds the Nerve Agent Cyclosarin and Spontaneously Hydrolyzes the Nerve Agent Sarin

Autor: Andrew C. Hemmert, John R. Cashman, Monika Wierdl, Mary MacDonald, Matthew R. Redinbo, Christopher D. Fleming, Douglas M. Cerasoli, Philip M. Potter, Tamara C. Otto, Carol C. Edwards

Publikováno v: Molecular Pharmacology. 77:508-516

Organophosphorus (OP) nerve agents are potent toxins that inhibit cholinesterases and produce a rapid and lethal cholinergic crisis. Development of protein-based therapeutics is being pursued with the goal of preventing nerve agent toxicity and prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe9db2983bcc2bdcf94f8c64fda229c
https://doi.org/10.1124/mol.109.062356