Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Andrew C, Penn"'
Autor:
Giles Winchester, Oliver G. Steele, Samuel Liu, Andre Maia Chagas, Wajeeha Aziz, Andrew C. Penn
Publikováno v:
Frontiers in Neuroinformatics, Vol 18 (2024)
Detection and analysis of spontaneous synaptic events is an extremely common task in many neuroscience research labs. Various algorithms and tools have been developed over the years to improve the sensitivity of detecting synaptic events. However, th
Externí odkaz:
https://doaj.org/article/4523956e934642679fff43b75a43e0b1
Autor:
Marwa Elmasri, James S. Lotti, Wajeeha Aziz, Oliver G. Steele, Eirini Karachaliou, Kenji Sakimura, Kasper B. Hansen, Andrew C. Penn
Publikováno v:
Brain Sciences, Vol 12, Iss 6, p 789 (2022)
GRIN2B mutations are rare but often associated with patients having severe neurodevelopmental disorders with varying range of symptoms such as intellectual disability, developmental delay and epilepsy. Patient symptoms likely arise from mutations dis
Externí odkaz:
https://doaj.org/article/8e4d846d461544c2aa4a98e20d3181e3
Autor:
D. Moolenaar Van Der Does, E. Karachaliou, M. Elmasri, G. Winchester, Andrew C. Penn, Kenji Sakimura, W. Aziz, D. Hunter, E. Bates
Publikováno v:
Communications Biology. 5
Dominant mutations in the human gene GRIN2A, encoding NMDA receptor (NMDAR) subunit GluN2A, make a significant and growing contribution to the catalogue of published single-gene epilepsies. Understanding the disease mechanism in these epilepsy patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2560bd14412544232342aa222cf45e0
https://doi.org/10.1038/s42003-022-03115-3
https://doi.org/10.1038/s42003-022-03115-3
Autor:
Daniel Choquet, Eric Hosy, Yann Humeau, François Georges, Andrew C. Penn, Christelle Breillat, L. Royer, Chun-Lei Zhang, Jennifer D. Petersen
Publikováno v:
Nature
Nature, Nature Publishing Group, 2017, 549 (7672), pp.384-388. ⟨10.1038/nature23658⟩
Nature, Nature Publishing Group, 2017, 549 (7672), pp.384-388. ⟨10.1038/nature23658⟩
Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice. Learning and memory are thought to rely o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05ec60bcf700cf18b702bd1de27bd658
https://hal.archives-ouvertes.fr/hal-03129961
https://hal.archives-ouvertes.fr/hal-03129961
Publikováno v:
Nucleic Acids Research
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3fa3fa57c2e8d868d08bc99438000e
http://europepmc.org/articles/PMC3553983
http://europepmc.org/articles/PMC3553983
Publikováno v:
Nucleic Acids Research
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb1cf6bb9546ffd9e4e70edbcadf15b
http://europepmc.org/articles/PMC3553965
http://europepmc.org/articles/PMC3553965
Publikováno v:
Neuron
Summary The AMPA-type glutamate receptor (AMPAR) subunit composition shapes synaptic transmission and varies throughout development and in response to different input patterns. Here, we show that chronic activity deprivation gives rise to synaptic AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c135970f90c68dc4bbd16b1b1ba3a5f
https://doi.org/10.1016/j.neuron.2012.08.010
https://doi.org/10.1016/j.neuron.2012.08.010
Autor:
Maxim Rossmann, Dmitry B. Veprintsev, Madhav Sukumaran, Andrew C. Penn, M. Madan Babu, Ingo H. Greger
Publikováno v:
The EMBO Journal. 30:959-971
The assembly of AMPA‐type glutamate receptors (AMPARs) into distinct ion channel tetramers ultimately governs the nature of information transfer at excitatory synapses. How cells regulate the formation of diverse homo‐ and heteromeric AMPARs is u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87767ab1064e9d5bd9d684078b1810c2
https://doi.org/10.1038/emboj.2011.16
https://doi.org/10.1038/emboj.2011.16
Autor:
Andrew C. Penn, Ingo H. Greger
Publikováno v:
RNA Biology. 6:517-521
AMPA receptors are ion channel tetramers that mediate fast excitatory neurotransmission in vertebrate brains. AMPAR functional properties as well as receptor biogenesis in the endoplasmic reticulum (ER) are shaped by RNA processing events, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745a0d617613239c6330ba257156b617
https://doi.org/10.4161/rna.6.5.9552
https://doi.org/10.4161/rna.6.5.9552
Publikováno v:
Trends in Neurosciences. 30:407-416
AMPA-type (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) glutamate receptors (AMPARs) mediate post-synaptic depolarization and fast excitatory transmission in the central nervous system. AMPARs are tetrameric ion channels that assemble in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a08b27ddcd1d2d047a62a7293863e5
https://doi.org/10.1016/j.tins.2007.06.005
https://doi.org/10.1016/j.tins.2007.06.005