Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Andrew C, Karaplis"'
Autor:
Dibyendu K. Panda, Xiuying Bai, Yan Zhang, Nicholas A. Stylianesis, Antonis E. Koromilas, Mark L. Lipman, Andrew C. Karaplis
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 24 (2022)
The Hippo pathway nuclear effector Yes-associated protein (YAP) potentiates the progression of polycystic kidney disease (PKD) arising from ciliopathies. The mechanisms underlying the increase in YAP expression and transcriptional activity in PKD rem
Externí odkaz:
https://doaj.org/article/805150cc024648f6bb0b0df97758d5bb
Autor:
Suhaib Radi, Andrew C. Karaplis
Publikováno v:
Case Reports in Endocrinology, Vol 2017 (2017)
While the contributing role of testosterone to bone health is rather modest compared to other factors such as estradiol levels, male hypogonadism is associated with low bone mass and fragility fractures. Along with stimulating physical puberty by ach
Externí odkaz:
https://doaj.org/article/a8127f4b7d3f4e3c9ad0b30e0751a8fd
Publikováno v:
The Journal of clinical endocrinology and metabolism. 107(10)
Context Autosomal recessive hypophosphatemic rickets (ARHR) are rare, heritable renal phosphate-wasting disorders that arise from overexpression of the bone-derived phosphaturic hormone fibroblast growth factor 23 (FGF23) leading to impaired bone min
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05e69d25764acb7cbdb2bed44ad4f26
https://pubmed.ncbi.nlm.nih.gov/35896139
https://pubmed.ncbi.nlm.nih.gov/35896139
Autor:
Zhiyuan Mao, Yaoyao Jin, Yongjie Zhang, Rong Wang, Qun Wang, Dengshun Miao, Qiangcheng Wang, Min Cui, Andrew C. Karaplis, Yahong Liu, Yi Ping Zhang, Christopher B. Shields, Lisa B E Shields
Publikováno v:
Developmental Neurobiology. 81:47-62
Parathyroid hormone-related peptide (PTHrP) acts under physiological conditions to regulate normal development of several tissues and organs. The role of PTHrP in spinal cord development has not been characterized. Pthrp knock in (Pthrp KI) mice were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49084a8548d1384aec365aae11c5679
https://doi.org/10.1002/dneu.22798
https://doi.org/10.1002/dneu.22798
Autor:
Zhen Gu, David Goltzman, Haijian Sun, Ying Zhang, Guangpei Chen, Dengshun Miao, Andrew C. Karaplis
Publikováno v:
International Journal of Biological Sciences
We previously demonstrated that parathyroid hormone-related peptide (PTHrP) 1-84 knockin (Pthrp KI) mice, which lacked a PTHrP nuclear localization sequence (NLS) and C-terminus, displayed early senescence, defective osteoblastic bone formation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3737b6401356c3eb3fe2f66e2eec723a
http://europepmc.org/articles/PMC5968843
http://europepmc.org/articles/PMC5968843
Autor:
Judy Maddox, Kenneth G. Saag, Michelle Fan, Jeffrey Petersen, Maria Luisa Brandi, Andrew C. Karaplis, Andreas Grauer, Paul D Meisner, Mattias Lorentzon, Thierry Thomas
Publikováno v:
New England Journal of Medicine. 377:1417-1427
BACKGROUND Romosozumab is a monoclonal antibody that binds to and inhibits sclerostin, increases bone formation, and decreases bone resorption. METHODS We enrolled 4093 postmenopausal women with osteoporosis and a fragility fracture and randomly assi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce24a6110edc816dbb3639902df5dcc
https://doi.org/10.1056/nejmoa1708322
https://doi.org/10.1056/nejmoa1708322
Autor:
Midori Yamaguchi, Hiroshi Shitara, Kazuhiro Okumura, Ryo Kominami, Eriko Isogai, Yuichi Wakabayashi, Ikuo Miura, Megumi Saito, Andrew C. Karaplis, Choji Taya, Shigeharu Wakana, Haruka Munakata, Yasuhiro Yoshizawa
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Using a forward genetics approach to map loci in a mouse skin cancer model, we previously identified a genetic locus, Skin tumour modifier of MSM 1 (Stmm1) on chromosome 7, conferring strong tumour resistance. Sub-congenic mapping localized Parathyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de8164d9b13ff5d9119cff5c36e62e0
http://link.springer.com/article/10.1038/s41598-017-11561-x
http://link.springer.com/article/10.1038/s41598-017-11561-x
Publikováno v:
Journal of Bone and Mineral Research. 33:2239-2241
To assess the effect of hypoparathyroidism on osteogenesis and bone turnover in vivo, bone marrow ablation (BMXs) were performed in tibias of 8-week-old wild-type and parathyroid hormone-null (PTH(-/-)) mice and newly formed bone tissue was analyzed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4d7b1856e8c203fed717e08aeeb8265
https://doi.org/10.1002/jbmr.3582
https://doi.org/10.1002/jbmr.3582
Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis
Autor:
Rui, Zhang, Jiarong, Li, Gloria, Assaker, Anne, Camirand, Siham, Sabri, Andrew C, Karaplis, Richard, Kremer
Publikováno v:
Advances in experimental medicine and biology. 1164
PTHrP was first discovered as the most common mediator of malignancy-associated hypercalcemia. Subsequently, the discovery of its ubiquitous expression in normal tissues unraveled its role as a physiological autocrine/paracrine regulator. The signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a3dada72b7b1eb675bb275b317a497e8
https://pubmed.ncbi.nlm.nih.gov/31576548
https://pubmed.ncbi.nlm.nih.gov/31576548
Parathyroid Hormone-Related Protein (PTHrP): An Emerging Target in Cancer Progression and Metastasis
Autor:
Andrew C. Karaplis, Gloria Assaker, Siham Sabri, Rui Zhang, Jiarong Li, Richard Kremer, Anne Camirand
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030222536
PTHrP was first discovered as the most common mediator of malignancy-associated hypercalcemia. Subsequently, the discovery of its ubiquitous expression in normal tissues unraveled its role as a physiological autocrine/paracrine regulator. The signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::071a50bcdb51ed83de81f05550a69cb3
https://doi.org/10.1007/978-3-030-22254-3_13
https://doi.org/10.1007/978-3-030-22254-3_13
