Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew Brearley"'
Autor:
Jens Kopatz, Rajesh V. Devraj, Melanie Hermann, R.O. Hughes, Raul Krauss, Antoine Berthemy, Kerstin Danker, Thomas M. Engber, Jonathan Bentley, Kenneth Young, Susan Boyce, Andrew Brearley, Todd Bosanac
Publikováno v:
Brain
Axonal degeneration is an early and ongoing event that causes disability and disease progression in many neurodegenerative disorders of the peripheral and central nervous systems. Chemotherapy-induced peripheral neuropathy (CIPN) is a major cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91a416a7a05248b425cb2d19ae0061d
http://europepmc.org/articles/PMC8634121
http://europepmc.org/articles/PMC8634121
Autor:
Yun Shi, Philip S. Kerry, Jeffrey D. Nanson, Todd Bosanac, Yo Sasaki, Raul Krauss, Forhad K. Saikot, Sarah E. Adams, Tamim Mosaiab, Veronika Masic, Xianrong Mao, Faith Rose, Eduardo Vasquez, Marieke Furrer, Katie Cunnea, Andrew Brearley, Weixi Gu, Zhenyao Luo, Lou Brillault, Michael J. Landsberg, Aaron DiAntonio, Bostjan Kobe, Jeffrey Milbrandt, Robert O. Hughes, Thomas Ve
Publikováno v:
Mol Cell
The NADase SARM1 (sterile alpha and TIR motif containing 1) is a key executioner of axon degeneration and a therapeutic target for several neurodegenerative conditions. We show that a potent SARM1 inhibitor undergoes base exchange with the nicotinami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3594ecc983f2e73022be37b1e325b787
https://doi.org/10.1016/j.molcel.2022.03.007
https://doi.org/10.1016/j.molcel.2022.03.007
Autor:
John R. Fozard, Martin Gosling, David Farr, Lynne Jordan, David A. Sykes, Darryl Brynley Jones, David Beattie, Joe Fullerton, Lyndon Nigel Brown, Julia Hatto, Rachel Profit, Mark Mercer, Diana Janus, Christine Lewis, Helen Oakman, Robin Alec Fairhurst, Friedrich Schuerch, Michelle Bradley, Nicola Arnold, Roger J. Taylor, Janet Maas, Steven J. Charlton, Andrew Brearley, Andrew R. Tuffnell, Alexandre Trifilieff, Clive Mccarthy, Neil John Press
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4341-4347
The optimisation of two series of 4-hydroxybenzothiazolone derived β2-adrenoceptor agonists, bearing α-substituted cyclopentyl and β-phenethyl amino-substituents, as inhaled long-acting bronchodilators is described. Analogues were selected for syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6783b59db6f184a0eb19d182e169bc4
https://doi.org/10.1016/j.bmcl.2014.06.014
https://doi.org/10.1016/j.bmcl.2014.06.014
Autor:
David Beattie, Christine Lewis, Clive Mccarthy, Darryl Brynley Jones, Andrew R. Tuffnell, Bernard Cuenoud, Robin Alec Fairhurst, Andrew Brearley, Martin Gosling, Helen Oakman, Rowan Stringer, Steven J. Charlton, Roger J. Taylor, Diana Janus, Michelle Bradley, Peter Gedeck
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:5302-5307
The chiral synthesis of a 4-hydroxybenzothiazolone based series of β2-adrenoceptor agonists is described. Using this methodology a library of N-substituted analogues were prepared for the rapid identification of leads with the potential to be fast o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a07dbf2769e10012f92d88393c10afb
https://doi.org/10.1016/j.bmcl.2010.06.136
https://doi.org/10.1016/j.bmcl.2010.06.136
Autor:
Robin Alec Fairhurst, James Neef, Brian Cox, Koremu Meja, Robert J. Turner, Paul Kirkham, David Beattie, Ryan West, Steven J. Charlton, Gillian Spooner, Helen Oakman, Zarin Brown, Lana Nanson, Roger J. Taylor, Hannah Woodward, John R. Fozard, Peter Gedeck, Andrew Brearley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1219-1224
The synthesis of two series of 4'-aza-carbocyclic nucleosides are described in which the 4'-substituent is either a reversed amide, relative to the carboxamide of NECA, or an N-bonded heterocycle. Using established purine substitution patterns, poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de070cc31c79e2dda4cfa38c65e5ab93
https://doi.org/10.1016/j.bmcl.2009.11.131
https://doi.org/10.1016/j.bmcl.2009.11.131
Autor:
Jeffrey P. Stonehouse, Neil John Press, Andrew Brearley, Peter Richard Curran, Charlotte E. Allen, Alan Armstrong, Valerie Boissel, Lilya Sviridenko
Publikováno v:
Organic letters. 17(3)
A kinetic template-guided tethering (KTGT) strategy has been developed for the site-directed discovery of fragments that bind to defined protein surfaces, where acrylamide-modified fragments can be irreversibly captured in a protein-templated conjuga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4db8dee2c44ad40edabe45671beece
https://pubmed.ncbi.nlm.nih.gov/25582165
https://pubmed.ncbi.nlm.nih.gov/25582165
Autor:
Andrew Brearley
Publikováno v:
Astropolitics. 4:43-67
The legal regime under which the resources of the Moon can be exploited is unclear. Recent proposals indicate that states are now planning to return to the Moon. Lunar resources offer great potential, both for terrestrial applications and in the expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fb23537215c91d13d13961754115800
https://doi.org/10.1080/14777620600762790
https://doi.org/10.1080/14777620600762790
Autor:
Andrew Brearley
Publikováno v:
Astropolitics. 3:1-34
Orbital debris, trapped in the Earth's gravity, presents a real and growing threat to human activity in space. This essay investigates the technical and legal environments within which the problem exists, questioning the available technical remedies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d237b9540b8ac0a7d1d8df6b613568af
https://doi.org/10.1080/14777620590933566
https://doi.org/10.1080/14777620590933566
Publikováno v:
Space Policy. 29:272-273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f629c676d992e5aaec169eedad1c04fe
https://doi.org/10.1016/j.spacepol.2013.10.003
https://doi.org/10.1016/j.spacepol.2013.10.003
Autor:
Andrew Brearley-Smith
Publikováno v:
BMJ. 292:628-628
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c720947bf34e84541ef15d37abb2b1
https://doi.org/10.1136/bmj.292.6520.628-e
https://doi.org/10.1136/bmj.292.6520.628-e