Yeast m6A Methylated mRNAs Are Enriched on Translating Ribosomes during Meiosis, and under Rapamycin Treatment.

Autor: Zsuzsanna Bodi, Andrew Bottley, Nathan Archer, Sean T May, Rupert G Fray

Publikováno v: PLoS ONE, Vol 10, Iss 7, p e0132090 (2015)

Interest in mRNA methylation has exploded in recent years. The sudden interest in a 40 year old discovery was due in part to the finding of FTO's (Fat Mass Obesity) N6-methyl-adenosine (m6A) deaminase activity, thus suggesting a link between obesity-

Externí odkaz: https://doaj.org/article/e1a48ac3b7a14424bb079b4bfb01a184

PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.

Autor: Frances R Wadelin, Joel Fulton, Hilary M Collins, Nikolaos Tertipis, Andrew Bottley, Keith A Spriggs, Franco H Falcone, David M Heery

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e58052 (2013)

Preferentially expressed antigen in melanoma (PRAME) has been described as a cancer-testis antigen and is associated with leukaemias and solid tumours. Here we show that PRAME gene transcription in leukaemic cell lines is rapidly induced by exposure

Externí odkaz: https://doaj.org/article/b32dad261bba42caabba91579d7a833f

Correction to ‘The human insulin receptor mRNA contains a functional internal ribosome entry segment’

Autor: Keith A Spriggs, Laura C Cobbold, Simon H Ridley, Mark Coldwell, Andrew Bottley, Martin Bushell, Anne E Willis, Kenneth Siddle

Publikováno v: Nucleic Acids Research. 50:1796-1798

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77965b89bb1074706a51d3313c7f74e9
https://doi.org/10.1093/nar/gkac063

Epigenetic Variation Amongst Polyploidy Crop Species

Autor: Andrew Bottley

Publikováno v: Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications ISBN: 9783030147594
Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications ISBN: 9783319079707

Many agronomically important crop species such as wheat are (or were once) polyploid, with at least one round of whole genome duplication occurring before domestication. This genetic buffering or redundancy allows for sequence divergence, and in turn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::661ac04b735b6006d16c6eec0244a2d1
https://doi.org/10.1007/978-3-030-14760-0_6

Methylation profiling RIN3 and MEF2C identifies epigenetic marks associated with sporadic early onset Alzheimer’s disease

Autor: Kevin Morgan, Sally Chappell, Imelda Barber, Tamar Guetta-Baranes, Andrew Bottley, Graham B. Seymour, Jim Craigon, Kirsty A Boden, Keeley J. Brookes, Naomi Clement, Tulsi Patel, Natalie H. Chapman

Publikováno v: Journal of Alzheimer's Disease Reports

A number of genetic loci associate with early onset Alzheimer’s disease (EOAD); however, the drivers of this disease remains enigmatic. Genome wide association and in vivo modeling have shown that loss-of-function, e.g., ABCA7, reduced levels of SI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca3ea27bd39b8e3421218de89cabaaf
https://nottingham-repository.worktribe.com/file/882225/1/adr%2F2017%2F1-1%2Fadr-1-1-adr170015%2Fadr-1-adr170015.pdf