Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Andrew Biggerstaff"'
Publikováno v:
Brain Sciences, Vol 12, Iss 12, p 1687 (2022)
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis. However, despite significant de
Externí odkaz:
https://doaj.org/article/bd9ea3cf9e564ff094ec2e868e086c14
Autor:
Kelly F. Paton, Andrew Biggerstaff, Sophia Kaska, Rachel S. Crowley, Anne C. La Flamme, Thomas E. Prisinzano, Bronwyn M. Kivell
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, cl
Externí odkaz:
https://doaj.org/article/b9f4351e6b5d472db7d619fb7f810bd9
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Declines in coral abundance have been linked to increased sedimentation at many locations across the world and at some of these locations there have been subsequent increases in sponge abundance. These shifts appear counterintuitive as spong
Externí odkaz:
https://doaj.org/article/90c57479820748d0bf2bf5445a0fcbda
Autor:
Bronwyn M. Kivell, Kelly F. Paton, Nitin Kumar, Aashish S. Morani, Aimee Culverhouse, Amy Shepherd, Susan A. Welsh, Andrew Biggerstaff, Rachel S. Crowley, Thomas E. Prisinzano
Publikováno v:
Molecules, Vol 23, Iss 10, p 2602 (2018)
The acute activation of kappa opioid receptors (KOPr) produces antinociceptive and anti-cocaine effects, however, their side-effects have limited further clinical development. Mesyl Sal B is a potent and selective KOPr analogue of Salvinorin A (Sal A
Externí odkaz:
https://doaj.org/article/b7c703a3687e4e638f6d6d30eadc40f1
Autor:
Bronwyn M. Kivell, Rachel Saylor Crowley, Andrew Biggerstaff, Thomas E. Prisinzano, Sophia Kaska, Kelly F. Paton, Anne C. La Flamme
Publikováno v:
Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 14 (2020)
Frontiers in Neuroscience, Vol 14 (2020)
In the search for safer, non-addictive analgesics, kappa opioid receptor (KOPr) agonists are a potential target, as unlike mu-opioid analgesics, they do not have abuse potential. Salvinorin A (SalA) is a potent and selective KOPr agonist, however, cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20244de8907edef6842a1b793d15fa89
http://europepmc.org/articles/PMC7385413
http://europepmc.org/articles/PMC7385413
Autor:
Jeffrey M. Witkin, Arnold Lippa, Jodi L. Smith, Xiaoming Jin, Xingjie Ping, Andrew Biggerstaff, Bronwyn M. Kivell, Daniel E. Knutson, Dishary Sharmin, Kamal P. Pandey, Md Yeunus Mian, James M. Cook, Rok Cerne
Publikováno v:
Pharmacology Biochemistry and Behavior. 213:173321
GABAkines, or positive allosteric modulators of γ-aminobutyric acid-A (GABA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74984dc2be7ee1b3fb7b3628e3acdc96
https://doi.org/10.1016/j.pbb.2021.173321
https://doi.org/10.1016/j.pbb.2021.173321
Autor:
Emily McGrath, Andrew Biggerstaff, Holly Bennett, Tracey Bates, Megan R. Shaffer, Joseph Marlow, James J. Bell
Publikováno v:
Ecological Indicators. 78:470-488
Monitoring has become a critical component of managing marine environments world-wide in the face of local and global anthropogenic impacts. Typically the focus of most monitoring programmes has been to quantify temporal and spatial variation in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::896389c46844480bb95af8a1228c07a1
https://doi.org/10.1016/j.ecolind.2017.03.001
https://doi.org/10.1016/j.ecolind.2017.03.001
Autor:
Victor W. Day, Bronwyn M. Kivell, Thomas E. Prisinzano, Rachel Saylor Crowley, Andrew Biggerstaff, Benjamin Neuenswander, Kelly F. Paton, Alexander M. Sherwood
Publikováno v:
Journal of Medicinal Chemistry. 60:3866-3878
Previous structure-activity studies on the neoclerodane diterpenoid salvinorin A have demonstrated the importance of the acetoxy functionality on the A-ring in its activity as a kappa opioid receptor agonist. Few studies have focused on understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1e7f637f16f625faf1ded8724f3ad03
https://doi.org/10.1021/acs.jmedchem.7b00148
https://doi.org/10.1021/acs.jmedchem.7b00148
Autor:
Sophia Kaska, Thomas E. Prisinzano, Lindsay Kornberger, Andrew Biggerstaff, Bronwyn M. Kivell
Publikováno v:
The FASEB Journal. 33
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a029fcc8e79b82330d32005ff2de273
https://doi.org/10.1096/fasebj.2019.33.1_supplement.663.14
https://doi.org/10.1096/fasebj.2019.33.1_supplement.663.14
Publikováno v:
Coral Reefs. 34:1049-1061
Changes to coral reefs are occurring worldwide, often resulting in declining environmental quality which can be in the form of higher sedimentation rates and increased turbidity. While environmental acclimation to turbid and low-light conditions has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a60accd05627ef654b95b820f22afae5
https://doi.org/10.1007/s00338-015-1340-9
https://doi.org/10.1007/s00338-015-1340-9