Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Andrew Berglund"'
Publikováno v:
Microorganisms, Vol 12, Iss 7, p 1499 (2024)
Zika virus (ZIKV), a re-emerging flavivirus, is associated with devasting developmental and neurological disease outcomes particularly in infants infected in utero. Towards understanding the molecular underpinnings of the unique ZIKV disease patholog
Externí odkaz:
https://doaj.org/article/31eed67e13b448a8b593dcf857e8991d
Publikováno v:
In Journal of Molecular Biology 1 August 2023 435(15)
Autor:
Emily E. Davey, Cécilia Légaré, Lori Planco, Sharon Shaughnessy, Claudia D. Lennon, Marie-Pier Roussel, Hannah K. Shorrock, Man Hung, John Douglas Cleary, Elise Duchesne, J. Andrew Berglund
Publikováno v:
JCI Insight, Vol 8, Iss 14 (2023)
Myotonic dystrophy type 1 (DM1), the most common form of adult-onset muscular dystrophy, is caused by a CTG expansion resulting in significant transcriptomic dysregulation that leads to muscle weakness and wasting. While strength training is clinical
Externí odkaz:
https://doaj.org/article/d641442504a74f18b3344b7cb793d359
Autor:
Jana R. Jenquin, Alana P. O’Brien, Kiril Poukalov, Yidan Lu, Jesus A. Frias, Hannah K. Shorrock, Jared I. Richardson, Hormoz Mazdiyasni, Hongfen Yang, Robert W. Huigens, III, David Boykin, Laura P.W. Ranum, John Douglas Cleary, Eric T. Wang, J. Andrew Berglund
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104198- (2022)
Summary: Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are common forms of adult onset muscular dystrophy. Pathogenesis in both diseases is largely driven by production of toxic-expanded repeat RNAs that sequester MBNL RNA-binding proteins, causin
Externí odkaz:
https://doaj.org/article/58816a4f83314c1bbc07ac1339b064d0
CCG•CGG interruptions in high‐penetrance SCA8 families increase RAN translation and protein toxicity
Autor:
Barbara A Perez, Hannah K Shorrock, Monica Banez‐Coronel, Tao Zu, Lisa EL Romano, Lauren A Laboissonniere, Tammy Reid, Yoshio Ikeda, Kaalak Reddy, Christopher M Gomez, Thomas Bird, Tetsuo Ashizawa, Lawrence J Schut, Alfredo Brusco, J Andrew Berglund, Lis F Hasholt, Jorgen E Nielsen, SH Subramony, Laura PW Ranum
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 11, Pp n/a-n/a (2021)
Abstract Spinocerebellar ataxia type 8 (SCA8), a dominantly inherited neurodegenerative disorder caused by a CTG•CAG expansion, is unusual because most individuals that carry the mutation do not develop ataxia. To understand the variable penetrance
Externí odkaz:
https://doaj.org/article/33aca9ac8dc84150a7d6116bee01440f
Autor:
Melissa N. Hinman, Jared I. Richardson, Rose A. Sockol, Eliza D. Aronson, Sarah J. Stednitz, Katrina N. Murray, J. Andrew Berglund, Karen Guillemin
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 6 (2021)
The muscleblind RNA-binding proteins (MBNL1, MBNL2 and MBNL3) are highly conserved across vertebrates and are important regulators of RNA alternative splicing. Loss of MBNL protein function through sequestration by CUG or CCUG RNA repeats is largely
Externí odkaz:
https://doaj.org/article/6f0a3d28e4c9477a8019cab6074dcf0b
Autor:
Jacob H Schroader, Lindsey A Jones, Ryan Meng, Hannah K Shorrock, Jared I Richardson, Sharon M Shaughnessy, Qishan Lin, Thomas J Begley, J Andrew Berglund, Gabriele Fuchs, Mark T Handley, Kaalak Reddy
Publikováno v:
Nucleic Acids Research. 50:9306-9318
Failure to prevent accumulation of the non-canonical nucleotide inosine triphosphate (ITP) by inosine triphosphate pyrophosphatase (ITPase) during nucleotide synthesis results in misincorporation of inosine into RNA and can cause severe and fatal dev
Addressing Persistent Vaccine Hesitancy in a Military Community Through a Physician-Led Intervention
Autor:
Joseph Glendening, Brant Bickford, Ronald Markert, Joseph Yuhas, Andrew Berglund, Devin Kelly, Joshua Scott, Kathryn Burtson
Publikováno v:
Military Medicine. 188:928-931
Introduction Following the identification of coronavirus disease 2019 (COVID-19) in China, the virus has spread rapidly around the world causing severe illness and death. Several vaccines were found to be safe and effective and made available first t
Autor:
Subodh K. Mishra, Sawyer M. Hicks, Jesus A. Frias, Sweta Vangaveti, Masayuki Nakamori, John D. Cleary, Kaalak Reddy, J. Andrew Berglund
Myotonic dystrophy is a multisystemic neuromuscular disease caused by either a CTG repeat expansion inDMPK(DM1) or a CCTG repeat expansion inCNBP(DM2). Transcription of the expanded alleles produces toxic gain-of-function RNA that sequester the MBNL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a3c829ed7e0874e8d64b3c410b07c0b
https://doi.org/10.1101/2023.02.02.526846
https://doi.org/10.1101/2023.02.02.526846