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Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection.

Autor: Linda M Sircy, Andrew G Ramstead, Lisa C Gibbs, Hemant Joshi, Andrew Baessler, Ignacio Mena, Adolfo García-Sastre, Lyska L Emerson, Keke C Fairfax, Matthew A Williams, J Scott Hale

Publikováno v: PLoS Pathogens, Vol 20, Iss 9, p e1011639 (2024)

Current influenza vaccine strategies have yet to overcome significant obstacles, including rapid antigenic drift of seasonal influenza viruses, in generating efficacious long-term humoral immunity. Due to the necessity of germinal center formation in

Externí odkaz: https://doaj.org/article/67badab4cd554c29b4561222bf73923a

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Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus

Autor: Phiroze Sethna, Andrew Bae, Katherine Sortino, Jeffrey M. Chamberlain, Robert A. Bambara, Stephen Dewhurst, Randall Lanier

Publikováno v: Antimicrobial Agents and Chemotherapy. 63

Human adenovirus (AdV) can cause fatal disease in immune-suppressed individuals, but treatment options are limited, in part because the antiviral cytidine analog cidofovir (CDV) is nephrotoxic. The investigational agent brincidofovir (BCV) is orally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529f45fefd47c7ffa416ea6fd1ba2e7e
https://doi.org/10.1128/aac.01925-18

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Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial

Autor: Roy F. Chemaly, Janet A. Englund, Gregory E. Chittick, Marion E. Morrison, Andrew Bae, Joanne Kurtzberg, Vinod K. Prasad, Michael Grimley, Thomas M. Brundage

Publikováno v: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 23(3)

Adenovirus infection in immunocompromised patients contributes to significant morbidity and mortality, especially after allogeneic hematopoietic cell transplantation (HCT). Brincidofovir (BCV, CMX001) is an orally bioavailable lipid conjugate of cido

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a9633df68ef854f77e06d30f3ba946d
https://pubmed.ncbi.nlm.nih.gov/28063938

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Characterization of Resistance to the Protease Inhibitor GS-9451 in Hepatitis C Virus-Infected Patients

Autor: Jeanette Harris, Andrew Bae, Hadas Dvory-Sobol, Michael D. Miller, Kelly A. Wong, Hongmei Mo, Phillip S. Pang, Karin S. Ku, Eric Lawitz

Publikováno v: Antimicrobial Agents and Chemotherapy. 56:5289-5295

GS-9451, a novel hepatitis C virus (HCV) nonstructural 3/4a (NS3/4a) protease inhibitor, is highly active in patients infected with HCV genotype 1 (GT 1). The aim of this study is to characterize the clinical resistance profile of GS-9451 in GT 1 HCV

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f03e83bee9898b4cbcbb0855c20fc0d7
https://doi.org/10.1128/aac.00780-12

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Development of a replicon-based phenotypic assay for assessing the drug susceptibilities of HCV NS3 protease genes from clinical isolates

Autor: Jeanette Harris, Xiaoping Qi, Michael I. Miller, Shan Liu, Andrew Bae, William E. Delaney, Siu-Chi Sun, Hongmei Mo, Huiling Yang

Publikováno v: Antiviral Research. 81:166-173

Hepatitis C virus (HCV) protease inhibitors targeting HCV NS3 can efficiently suppress HCV replication. However, the selection of resistance has been observed both in vitro and in vivo. Here, we describe a new method for efficient analysis of the dru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90290d437f53ab4cf3d3b92d7c76bc2
https://doi.org/10.1016/j.antiviral.2008.11.002

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Low-Level K65R Mutation in HIV-1 Reverse Transcriptase of Treatment-Experienced Patients Exposed to Abacavir or Didanosine

Autor: Andrew Bae, Katyna Borroto-Esoda, Lijie Zhong, Nicolas A. Margot, Evguenia S. Svarovskaia, Derrick D. Goodman, Michael D. Miller, Joshua M. Waters

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 46:174-180

Background: Prior abacavir (ABC) or didanosine (ddI) therapy can result in the L74V/I or K65R mutation in HIV-1 reverse transcriptase. Preexisting K65R may have an impact on the treatment response to tenofovir disoproxil fumarate (TDF). Methods: An a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4afb363cb65ae714dd5b460d039a31
https://doi.org/10.1097/qai.0b013e31814258c0

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Viral Kinetics of the Y448H HCV NS5B Polymerase Mutant in Patients Treated with the HCV Inhibitor Tegobuvir (GS-9190)

Autor: Karin S. Ku, Evguenia S. Svarovskaia, Andrew Bae, Derrick D. Goodman, Hongmei Mo, Michael D. Miller

Publikováno v: Journal of Antivirals & Antiretrovirals.

Tegobuvir (GSâ9190) is a novel hepatitis C virus (HCV) nonânucleoside NS5B polymerase inhibitor that effectively inhibits HCV replication in HCV-infected genotype (GT) 1 patients. The NS5B Y448H mutation was the most frequent mutation selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91e21a0b1ed57b10517c0fd9b5e83605
https://doi.org/10.4172/jaa.1000071

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