Výsledky vyhledávání - "Andrew B. Mahon"

Akademický článek

Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease

Autor: Jing Li, Si-Yeon Jeong, Bei Xiong, Alan Tseng, Andrew B. Mahon, Steven Isaacman, Victor R. Gordeuk, Jaehyung Cho

Publikováno v: Haematologica, Vol 105, Iss 10 (2019)

Adherent neutrophils on vascular endothelium positively contribute to cell-cell aggregation and vaso-occlusion in sickle cell disease. In the present study, we demonstrated that pyridoxamine, a derivative of vitamin B6, might be a therapeutic agent t

Externí odkaz: https://doaj.org/article/77a14f9508c8473c951c1fea43d01edf

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Akademický článek

Synthesis of 5,6,11,12-tetrahydrodibenzo[b,f][1,5]diazocines and a demonstration of their reactivity to afford methano strap-modified Tröger’s base analogues

Autor: Andrew B. Mahon, Donald C. Craig, Andrew C. Try

Publikováno v: ARKIVOC, Vol 2008, Iss 12, Pp 148-163 (2008)

Externí odkaz: https://doaj.org/article/6257783559be4f5dacafd82c3189aa92

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Akademický článek

5,11-Dimethyldibenzo[b,f][1,5]diazocine-6,12(5H,11H)-dione

Autor: Andrew C. Try, Paul Jensen, Andrew B. Mahon

Publikováno v: Acta Crystallographica Section E, Vol 64, Iss 2, Pp o469-o469 (2008)

In the molecule of the title compound, C16H14N2O2, an N,N′-dimethyldianthranilide, the two methyl groups are disordered over two positions; site occupation factors were kept fixed as 0.75:0.25 and 0.65:0.35. The dihedral angle between the two benze

Externí odkaz: https://doaj.org/article/ecd129efa50a4bef983c654ca7e285b1

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Frequency of procedural and medical treatments of actinic keratosis

Autor: Steven R. Feldman, Varun Ranpariya, Andrew B Mahon, Suraj Muddasani

Publikováno v: Ranpariya, V K, Muddasani, S, Mahon, A B & Feldman, S R 2022, ' Frequency of procedural and medical treatments of actinic keratosis ', Journal of the American Academy of Dermatology, vol. 86, no. 4, pp. 916-918 . https://doi.org/10.1016/j.jaad.2021.03.047

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eeb74441ae1cf7a417fad48742b88b
https://findresearcher.sdu.dk:8443/ws/files/182533531/Frequency_of_Procedural_and_Medical_Treatments_of_Actinic_Keratosis.pdf

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Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease

Autor: Jaehyung Cho, Bei Xiong, Jing Li, Steven Isaacman, Victor R. Gordeuk, Andrew B. Mahon, Si-Yeon Jeong, Alan Tseng

Publikováno v: Haematologica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1936abda689d323b263f0e2ebe133f
http://europepmc.org/articles/PMC7556679

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An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics

Autor: Paramjit S. Arora, Michael G. Wuo, Andrew B. Mahon

Publikováno v: Journal of the American Chemical Society

Coiled coils are a major motif in proteins and orchestrate multimerization of various complexes important for biological processes. Inhibition of coiled coil-mediated interactions has significant biomedical potential. However, general approaches that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f3fca29cc8f1059e4d23b54b111e5a
http://europepmc.org/articles/PMC4577959

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Constrained peptide helices

Autor: Paramjit S. Arora, Andrew B. Mahon

Publikováno v: Understanding and Exploiting Protein–Protein Interactions as Drug Targets. :62-73

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b152e29239c2cfc5d949e9cf35865894
https://doi.org/10.4155/ebo.13.172

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Reaction of Tröger’s base analogues with Vilsmeier reagents

Autor: Donald C. Craig, Andrew C. Try, Andrew B. Mahon, Qasim M. Malik

Publikováno v: Tetrahedron. 67:8509-8514

As part of a program aimed at introducing functionality onto the Troger’s base framework post-synthesis, we investigated the formylation reaction of Troger’s base analogues with Vilsmeier reagents. We found that rather than the anticipated reacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf79418c94df2470f8883ae6cf61c241
https://doi.org/10.1016/j.tet.2011.08.095

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Synthesis of Symmetric Dinitro-Functionalised Tröger's Base Analogues

Autor: M. Delower H. Bhuiyan, Andrew B. Mahon, Andrew C. Try, Paul H. Jensen, Jack K. Clegg

Publikováno v: European Journal of Organic Chemistry. 2009:687-698

The synthesis of six new examples of 2,8-dinitro-substituted Troger's base analogues are reported, together with the first examples of 1,7-, 3,9- and 4,10-dinitro Troger's base analogues and the first example of a tetranitro Troger's base compound. S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::977d2068e9d28b6534cc1f75c8191b8b
https://doi.org/10.1002/ejoc.200801032

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