Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Andrew B. Lane"'
Autor:
Katherine L Furniss, Hung-Ji Tsai, Jo Ann W Byl, Andrew B Lane, Amit C Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J Clarke
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003832 (2013)
By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes. In humans, the strand passage reaction of DNA topoisomerase II (Topo II) is the target of s
Externí odkaz:
https://doaj.org/article/925baffde6b44627b6f84bc643f95894
Autor:
Andreas Ettinger, Magdalena Strzelecka, Andrew B. Lane, Torsten Wittmann, Rebecca Heald, Andrew W. Grenfell
Publikováno v:
Developmental cell, vol 34, iss 3
Lane, AB; Strzelecka, M; Ettinger, A; Grenfell, AW; Wittmann, T; & Heald, R. (2015). Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening. Developmental Cell. doi: 10.1016/j.devcel.2015.06.003. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5t94d8b1
Lane, AB; Strzelecka, M; Ettinger, A; Grenfell, AW; Wittmann, T; & Heald, R. (2015). Enzymatically Generated CRISPR Libraries for Genome Labeling and Screening. Developmental Cell. doi: 10.1016/j.devcel.2015.06.003. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/5t94d8b1
© 2015 Elsevier Inc. CRISPR-based technologies have emerged as powerful tools to alter genomes and mark chromosomal loci, but an inexpensive method for generating large numbers of RNA guides for whole genome screening and labeling is lacking. Using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5727725aa1277506352b8316f54e0f
https://doi.org/10.1016/j.devcel.2015.06.003
https://doi.org/10.1016/j.devcel.2015.06.003
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1703
Topoisomerase II activity is crucial to maintain genome stability through the removal of catenanes in the DNA formed during DNA replication and scaffolding the mitotic chromosome. Perturbed Topo II activity causes defects in chromosome segregation du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::10cd28ac30a892c9010409d36572048d
https://pubmed.ncbi.nlm.nih.gov/29177745
https://pubmed.ncbi.nlm.nih.gov/29177745
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1703
For analyzing chromosome structural defects that result from topoisomerase II (topo II) dysfunction we have adapted classical cell cycle experiments, classical cytological techniques and the use of a potent topo II inhibitor (ICRF-193). In this chapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92a67910365a94b0bae58dfc42cd474d
https://pubmed.ncbi.nlm.nih.gov/29177744
https://pubmed.ncbi.nlm.nih.gov/29177744
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974580
For analyzing chromosome structural defects that result from topoisomerase II (topo II) dysfunction we have adapted classical cell cycle experiments, classical cytological techniques and the use of a potent topo II inhibitor (ICRF-193). In this chapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6481c752e1799f24154d8f98feffde53
https://doi.org/10.1007/978-1-4939-7459-7_15
https://doi.org/10.1007/978-1-4939-7459-7_15
Publikováno v:
Methods in Molecular Biology ISBN: 9781493974580
Topoisomerase II activity is crucial to maintain genome stability through the removal of catenanes in the DNA formed during DNA replication and scaffolding the mitotic chromosome. Perturbed Topo II activity causes defects in chromosome segregation du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230b338c2429449b0fff2ab5ddd71c06
https://doi.org/10.1007/978-1-4939-7459-7_16
https://doi.org/10.1007/978-1-4939-7459-7_16
A novel chromatin tether domain controls topoisomerase IIα dynamics and mitotic chromosome formation
Publikováno v:
The Journal of Cell Biology
The dynamics of topoisomerase IIα binding to DNA and histones are important for successful mitosis and are regulated by a novel chromatin tether (ChT) domain in topoisomerase IIα.
DNA topoisomerase IIα (Topo IIα) is the target of an importan
DNA topoisomerase IIα (Topo IIα) is the target of an importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db896bacf0396780d0009f17839c2728
https://doi.org/10.1083/jcb.201303045
https://doi.org/10.1083/jcb.201303045
Autor:
Duncan J. Clarke, Andrew B. Lane
Publikováno v:
BioEssays. 34:963-972
Recent data show that catastrophic events during one cell cycle can cause massive genome damage producing viable clones with unstable genomes. This is in contrast with the traditional view that tumorigenesis requires a long-term process in which muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28b0941df12eac92a653b2c11d06ebe8
https://doi.org/10.1002/bies.201200082
https://doi.org/10.1002/bies.201200082
Publikováno v:
Methods in Molecular Biology ISBN: 9781607613398
Topoisomerase II activity is crucial to maintain genome stability through the removal of catenanes in the DNA formed during DNA replication and scaffolding the mitotic chromosome. Perturbed Topo II activity causes defects in chromosome segregation du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84febc40b901362af62ed7d5a5a5774b
https://doi.org/10.1007/978-1-60761-340-4_14
https://doi.org/10.1007/978-1-60761-340-4_14
Autor:
Duncan J. Clarke, Andrew B. Lane
Publikováno v:
Methods in Molecular Biology ISBN: 9781607613398
DNA topoisomerases are enzymes that alter the topology of DNA. They have important functions in DNA replication, transcription, Holliday junction dissolution, chromosome condensation, and sister chromatid separation. Deficiencies in these enzymes are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605a4728f5667f9a7fb460ec101c56b8
https://doi.org/10.1007/978-1-60761-340-4_1
https://doi.org/10.1007/978-1-60761-340-4_1