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pro vyhledávání: '"Andrew B. Knott"'
Autor:
Andrew B. Knott, Ella Bossy-Wetzel
Mitochondria are dynamic organelles that are of critical importance for cellular survival and health. Because mitochondria play central roles in energy production and synaptic maintenance, neurons are believed to be particularly vulnerable to mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92e828da874765b250d64feafa6a29a
https://doi.org/10.1093/med/9780190233563.003.0012
https://doi.org/10.1093/med/9780190233563.003.0012
Autor:
Andrew B. Knott, Ella Bossy-Wetzel
Publikováno v:
Antioxidants & Redox Signaling. 11:541-553
Nitric oxide (NO) is an important messenger molecule in a variety of physiological systems. NO, a gas, is produced from L-arginine by different isoforms of nitric oxide synthase (NOS) and serves many normal physiologic purposes, such as promoting vas
Autor:
Ella Bossy-Wetzel, Andrew B. Knott
Publikováno v:
Annals of the New York Academy of Sciences. 1147:283-292
Mitochondrial dysfunction is a common characteristic of all neurodegenerative diseases. However, the cause of this dysfunction remains a mystery. Here, we discuss the potential role of mitochondrial fission and fusion in the onset and progression of
Publikováno v:
Nature Reviews Neuroscience. 9:505-518
Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondrial fission and fusion ensure metabolite and mitochondrial DNA (mtDNA) mixing and dictate organelle shape, number and bioenergetic functionality. There
Autor:
Ella Bossy-Wetzel, Andrew B. Knott
Publikováno v:
Cell Death & Differentiation. 14:1985-1988
superoxide dismutase 1 (SOD1). Furthermore, theresults indicate that mutant SOD1 astrocytes release one ormore toxic substances that selectively kill both mutant andwild-type motor neurons. These discoveries signal newdirections for ALS research and
Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by a single-gene mutation: a CAG expansion in the huntingtin (HTT) gene that results in production of a mutated protein, mutant HTT, with a polyglutamine tail (polyQ-HTT). A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497560e04bfc9b20f3445afca6017396
https://europepmc.org/articles/PMC4532781/
https://europepmc.org/articles/PMC4532781/
Autor:
Andrew B. Knott, Ella Bossy-Wetzel
Nitric oxide (NO) serves as a messenger molecule in a variety of physiological systems and also converts into toxic radical species that can damage cells through a process known as nitrosative stress. While the physiological roles of NO in blood vess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58ff7d53b150d8d0605cad681a8b6592
https://europepmc.org/articles/PMC3988980/
https://europepmc.org/articles/PMC3988980/
Autor:
Alejandra M. Petrilli, Blaise Bossy, Andrew B. Knott, Eva Klinglmayr, Ursula Lütz-Meindl, Ella Bossy-Wetzel, Eliezer Masliah, Jin Chen, Robert Schwarzenbacher
Mitochondrial dysfunction and synaptic loss are among the earliest events linked to Alzheimer's disease (AD) and might play a causative role in disease onset and progression. The underlying mechanisms of mitochondrial and synaptic dysfunction in AD r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06e2fb5735b37566e9570ce123df0a7
https://europepmc.org/articles/PMC2893334/
https://europepmc.org/articles/PMC2893334/
Autor:
Wenjun Song, Andrew Hicks, Ola J. Martin, Sarah Lubitz, Ella Bossy-Wetzel, Andrew B. Knott, Blaise Bossy
Publikováno v:
Methods (San Diego, Calif.). 46(4)
Mitochondrial morphology and length change during fission and fusion and mitochondrial movement varies dependent upon the cell type and the physiological conditions. Here, we describe fundamental wide-field fluorescence microscopy and 3D imaging tech
Publikováno v:
Trends in neurosciences. 31(12)
Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder that gradually robs affected individuals of memory, cognitive skills and normal movements. Although research has identified a single faulty gene, the huntingtin gene, as the c