Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Andrew B. Clippingdale"'
Publikováno v:
Protein & Peptide Letters. 11:377-384
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures are available to minimize or even abolish the negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60b9a0acffbac6ea9943151d18ccd1ab
https://doi.org/10.2174/0929866043406986
https://doi.org/10.2174/0929866043406986
Publikováno v:
Journal of Peptide Science. 6:225-234
Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::085d5b61692e12f6d071aa269203096c
https://doi.org/10.1002/(sici)1099-1387(200005)6:5<225::aid-psc244>3.0.co
https://doi.org/10.1002/(sici)1099-1387(200005)6:5<225::aid-psc244>3.0.co
Autor:
Andrew B. Clippingdale, Colin J. Barrow, Colin L. Masters, David H. Small, Konrad Beyreuther, Su San Mok
Publikováno v:
Journal of Neuroscience Research. 61:449-457
The major constituent of amyloid plaques in the Alzheimer disease (AD) brain is the amyloid protein (A beta). A beta has been shown to be neurotoxic to cells, but the exact mechanism of its effects are still not known. Most studies have focussed on A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90c397a5b55246db27ce8432493405dd
https://doi.org/10.1002/1097-4547(20000815)61:4<449::aid-jnr12>3.0.co
https://doi.org/10.1002/1097-4547(20000815)61:4<449::aid-jnr12>3.0.co
Publikováno v:
Letters in Peptide Science. 6:289-293
Modifications to secondary structure and fibril formation caused by multiple acetylHmb backbone amide protection of Alzheimer's disease Aβ(1-40) were investigated using circular dichroism spectroscopy and electron microscopy. Penta(acetylHmb)Aβ(1-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::528e0cdc408017ba125bf590e9d12b59
https://doi.org/10.1007/bf02443424
https://doi.org/10.1007/bf02443424
Publikováno v:
The Journal of Peptide Research. 53:665-672
The Fmoc solid phase synthesis of A beta(1-40), a strongly aggregating peptide found in Alzheimer's disease brain, was performed using 2-hydroxy-4-methoxybenzyl (Hmb) backbone amide protection. Hmb-Gly residues were incorporated using N(alpha)-Fmoc-H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5edc6ae7aadf137357abc53effa02450
https://doi.org/10.1034/j.1399-3011.1999.00065.x
https://doi.org/10.1034/j.1399-3011.1999.00065.x
Autor:
Jiuya He, John E. Walker, Alan J. Robinson, Ian J. Holt, Johannes N. Spelbrink, Michael E. Harbour, Chih-Chieh Mao, Aurelio Reyes, Andrew B. Clippingdale, Stefanie Reichelt, Miriam Di Re, Ian M. Fearnley, Caroline Granycome, Hiroshi Sembongi
Publikováno v:
The Journal of Cell Biology
Many copies of mammalian mitochondrial DNA contain a short triple-stranded region, or displacement loop (D-loop), in the major noncoding region. In the 35 years since their discovery, no function has been assigned to mitochondrial D-loops. We purifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56edc5d366edd9397a9a41e49434a183
https://www.repository.cam.ac.uk/handle/1810/266268
https://www.repository.cam.ac.uk/handle/1810/266268
Autor:
James S. Eddes, Richard J. Simpson, Andrew B. Clippingdale, Lisa M. Connolly, Robert L. Moritz, Hong Ji, Eugene A. Kapp, Sam Gilbert
Publikováno v:
Proteomics. 5(13)
Free-flow electrophoresis (FFE) and rapid (6 min) RP-HPLC was used to fractionate human citrate-treated plasma. Prior to analysis, the six most abundant proteins in plasma were removed by immunoaffinity chromatography; both depleted plasma and the fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd38925e44c3adbe93db9e8b75fc094
https://pubmed.ncbi.nlm.nih.gov/16052629
https://pubmed.ncbi.nlm.nih.gov/16052629
Publikováno v:
ChemInform. 36
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures are available to minimize or even abolish the negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb706984dad5fb9f6fecc52e286f288
https://doi.org/10.1002/chin.200523256
https://doi.org/10.1002/chin.200523256
Publikováno v:
Protein and peptide letters. 11(4)
The phenomenon of "difficult sequence" has long frustrated chemists in their efforts to assemble peptides that contain such sequences by solid phase synthesis methods. A variety of remedial measures are available to minimize or even abolish the negat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cbebf79df7449ee2db8406a9080b91a
https://pubmed.ncbi.nlm.nih.gov/15327371
https://pubmed.ncbi.nlm.nih.gov/15327371
Autor:
Nicola F. Dawson, Antonia A. Claasz, John D. Wade, Geoffrey W. Tregear, Kathryn J. Smith, Ping Fu, Andrew B. Clippingdale, Marc N. Mathieu
Publikováno v:
ChemInform. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87084216514bfafe3825120fd8b33b7c
https://doi.org/10.1002/chin.200345270
https://doi.org/10.1002/chin.200345270