Zobrazeno 1 - 10
of 300
pro vyhledávání: '"Andrew B Lassman"'
Autor:
Osama Al-Dalahmah, Michael G. Argenziano, Adithya Kannan, Aayushi Mahajan, Julia Furnari, Fahad Paryani, Deborah Boyett, Akshay Save, Nelson Humala, Fatima Khan, Juncheng Li, Hong Lu, Yu Sun, John F. Tuddenham, Alexander R. Goldberg, Athanassios Dovas, Matei A. Banu, Tejaswi Sudhakar, Erin Bush, Andrew B. Lassman, Guy M. McKhann, Brian J. A. Gill, Brett Youngerman, Michael B. Sisti, Jeffrey N. Bruce, Peter A. Sims, Vilas Menon, Peter Canoll
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Glioblastoma (GBM) diffusely infiltrates the brain and intermingles with non-neoplastic brain cells, including astrocytes, neurons and microglia/myeloid cells. This complex mixture of cell types forms the biological context for therapeutic r
Externí odkaz:
https://doaj.org/article/84706af8be0f4cffa61c89d018e75e54
Autor:
Thomas J. Kaley, Katherine S. Panageas, Elena I. Pentsova, Ingo K. Mellinghoff, Craig Nolan, Igor Gavrilovic, Lisa M. DeAngelis, Lauren E. Abrey, Eric C. Holland, Antonio Omuro, Mario E. Lacouture, Emmy Ludwig, Andrew B. Lassman
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 4, Pp 429-436 (2020)
Abstract Purpose Malignant glioma (MG) is the most deadly primary brain cancer. Signaling though the PI3K/AKT/mTOR axis is activated in most MGs and therefore a potential therapeutic target. The mTOR inhibitor temsirolimus and the AKT inhibitor perif
Externí odkaz:
https://doaj.org/article/12a34fde3fdf4d90a2d5bd4a3dc14ad8
Autor:
Mayu O. Frank, Takahiko Koyama, Kahn Rhrissorrakrai, Nicolas Robine, Filippo Utro, Anne-Katrin Emde, Bo-Juen Chen, Kanika Arora, Minita Shah, Heather Geiger, Vanessa Felice, Esra Dikoglu, Sadia Rahman, Alice Fang, Vladimir Vacic, Ewa A. Bergmann, Julia L. Moore Vogel, Catherine Reeves, Depinder Khaira, Anthony Calabro, Duyang Kim, Michelle F. Lamendola-Essel, Cecilia Esteves, Phaedra Agius, Christian Stolte, John Boockvar, Alexis Demopoulos, Dimitris G. Placantonakis, John G. Golfinos, Cameron Brennan, Jeffrey Bruce, Andrew B. Lassman, Peter Canoll, Christian Grommes, Mariza Daras, Eli Diamond, Antonio Omuro, Elena Pentsova, Dana E. Orange, Stephen J. Harvey, Jerome B. Posner, Vanessa V. Michelini, Vaidehi Jobanputra, Michael C. Zody, John Kelly, Laxmi Parida, Kazimierz O. Wrzeszczynski, Ajay K. Royyuru, Robert B. Darnell
Publikováno v:
BMC Medical Genomics, Vol 12, Iss 1, Pp 1-16 (2019)
Abstract Background Prompted by the revolution in high-throughput sequencing and its potential impact for treating cancer patients, we initiated a clinical research study to compare the ability of different sequencing assays and analysis methods to a
Externí odkaz:
https://doaj.org/article/11a5273709844f08a3cc53b25ce39717
Autor:
Prabhjot S. Mundi, Filemon S. Dela Cruz, Adina Grunn, Daniel Diolaiti, Audrey Mauguen, Allison R. Rainey, Kristina Guillan, Armaan Siddiquee, Daoqi You, Ronald Realubit, Charles Karan, Michael V. Ortiz, Eugene F. Douglass, Melissa Accordino, Suzanne Mistretta, Frances Brogan, Jeffrey N. Bruce, Cristina I. Caescu, Richard D. Carvajal, Katherine D. Crew, Guarionex Decastro, Mark Heaney, Brian S. Henick, Dawn L. Hershman, June Y. Hou, Fabio M. Iwamoto, Joseph G. Jurcic, Ravi P. Kiran, Michael D. Kluger, Teri Kreisl, Nicole Lamanna, Andrew B. Lassman, Emerson A. Lim, Gulam A. Manji, Guy M. McKhann, James M. McKiernan, Alfred I. Neugut, Kenneth P. Olive, Todd Rosenblat, Gary K. Schwartz, Catherine A. Shu, Michael B. Sisti, Ana Tergas, Reena M. Vattakalam, Mary Welch, Sven Wenske, Jason D. Wright, Peter Canoll, Hanina Hibshoosh, Kevin Kalinsky, Mahalaxmi Aburi, Peter A. Sims, Mariano J. Alvarez, Andrew L. Kung, Andrea Califano
Publikováno v:
Cancer Discovery. :OF1-OF22
Predicting in vivo response to antineoplastics remains an elusive challenge. We performed a first-of-kind evaluation of two transcriptome-based precision cancer medicine methodologies to predict tumor sensitivity to a comprehensive repertoire of clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2372be69c8c6242e5877bc9ce0d6bdc4
https://doi.org/10.1158/2159-8290.cd-22-1020
https://doi.org/10.1158/2159-8290.cd-22-1020
Autor:
Maximilian J. Mair, Rupert Bartsch, Emilie Le Rhun, Anna S. Berghoff, Priscilla K. Brastianos, Javier Cortes, Hui K. Gan, Nancy U. Lin, Andrew B. Lassman, Patrick Y. Wen, Michael Weller, Martin van den Bent, Matthias Preusser
Publikováno v:
Nature Reviews Clinical Oncology. 20:372-389
Antibody–drug conjugates (ADCs), a class of targeted cancer therapeutics combining monoclonal antibodies with a cytotoxic payload via a chemical linker, have already been approved for the treatment of several cancer types, with extensive clinical d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f719b8a742aa6859a0fc1f389ab55895
https://doi.org/10.1038/s41571-023-00756-z
https://doi.org/10.1038/s41571-023-00756-z
Publikováno v:
Neuro-Oncology, 25(6), 1015-1016. Oxford University Press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a79d4a605f952cfb4acfafb2a6830c
https://pure.eur.nl/en/publications/fc9716d1-4c94-4de4-b0e6-b0b27eb930ee
https://pure.eur.nl/en/publications/fc9716d1-4c94-4de4-b0e6-b0b27eb930ee
Autor:
Priya U Kumthekar, Michael J Avram, Andrew B Lassman, Nancy U Lin, Eudocia Lee, Sean A Grimm, Margaret Schwartz, Kirsten L Bell Burdett, Rimas V Lukas, Karan Dixit, Isabella Perron, Hui Zhang, William J Gradishar, Elena I Pentsova, Suriya Jeyapalan, Morris D Groves, Michelle Melisko, Jeffrey J Raizer
Publikováno v:
Neuro-Oncology. 25:557-565
Background Patients with human epidermal growth factor receptor 2-positive (HER2-positive) cancers have a high incidence of central nervous system (CNS) spread, but unfortunately systemic trastuzumab which targets the HER2 receptor has little CNS pen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f77768f1b6a19e682c66e9d528a059e2
https://doi.org/10.1093/neuonc/noac195
https://doi.org/10.1093/neuonc/noac195
Autor:
Andrew B Lassman, Stephanie L Pugh, Tony J C Wang, Kenneth Aldape, Hui K Gan, Matthias Preusser, Michael A Vogelbaum, Erik P Sulman, Minhee Won, Peixin Zhang, Golnaz Moazami, Marian S Macsai, Mark R Gilbert, Earle E Bain, Vincent Blot, Peter J Ansell, Suvajit Samanta, Madan G Kundu, Terri S Armstrong, Jeffrey S Wefel, Clemens Seidel, Filip Y de Vos, Sigmund Hsu, Andrés F Cardona, Giuseppe Lombardi, Dmitry Bentsion, Richard A Peterson, Craig Gedye, Véronique Bourg, Antje Wick, Walter J Curran, Minesh P Mehta
Publikováno v:
Neuro-Oncology. 25:339-350
Background Approximately 50% of newly diagnosed glioblastomas (GBMs) harbor epidermal growth factor receptor gene amplification (EGFR-amp). Preclinical and early-phase clinical data suggested efficacy of depatuxizumab mafodotin (depatux-m), an antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61cba05f685b47a6b772842ddcb1f753
https://doi.org/10.1093/neuonc/noac173
https://doi.org/10.1093/neuonc/noac173
Autor:
Meghna S. Trivedi, Melissa K. Accordino, Fabio M. Iwamoto, Deanna Fisher, Lan Huynh, Kathleen Fenn, Julie Ann Mayer, Kevin Kalinsky, Dawn L. Hershman, Julia E. McGuinness, David Cieremans, Edgar V. Sales, Mary Welch, Margaux Wooster, Robbie Schultz, Shing Lee, Lauren Franks, Teri N. Kreisl, Andrew B. Lassman, Katherine D. Crew, Veena M. Singh, Aya Haggiagi
Publikováno v:
Clin Breast Cancer
Diagnosis of LM is limited by low sensitivity of cerebrospinal fluid (CSF) cytopathology. Detecting tumor cells in CSF (CSF-TCs) might be more sensitive. We evaluated if CNSide (CNSide), a novel assay for tumor cell detection in CSF, can detect CSF-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18518ec147e6d5e4d96fd13d4dcbb832
https://doi.org/10.1016/j.clbc.2021.11.002
https://doi.org/10.1016/j.clbc.2021.11.002
Autor:
Ingo K. Mellinghoff, Timothy F. Cloughesy, Minesh P. Mehta, Paul S. Mischel, John G. Kuhn, William H. Yong, Lisa M. DeAngelis, Andrew B. Lassman, Nian Wu, Steve Horvath, Howard A. Fine, Michael D. Prados, Susan M. Chang, Kathleen R. Lamborn, Patrick Y. Wen, Jan Drappatz, David A. Reardon, Mark R. Gilbert, W. K. Alfred Yung, Frank Lieberman, Linda M. Liau, Adriana Heguy, Cameron W. Brennan, Alicia Pedraza, Julie Dang, Daisuke Kuga, Akio Iwanami, Shaojun Zhu, Hui Tao, Nicolas Yannuzzi, Milan G. Chheda, Barbara Oldrini, Sara Kubek, Phioanh Leia Nghiemphu, Christian Grommes, Carl Campos, Daniel Rohle, H. Ian Robins, Igor Vivanco
mp3 file (11 MB). In the May edition of the Cancer Discovery podcast, Science Writer Elizabeth McKenna talks with Ingo K. Mellinghoff about his paper, which suggests that the disappointing clinical activity of first-generation EGFR inhibitors in glio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61ea84dde1575a2f19855b3499939fbe
https://doi.org/10.1158/2159-8290.22529031.v1
https://doi.org/10.1158/2159-8290.22529031.v1