Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Andrew B Lassar"'
Publikováno v:
PLoS Genetics, Vol 10, Iss 1, p e1004072 (2014)
In the limb bud, patterning along the anterior-posterior (A-P) axis is controlled by Sonic Hedgehog (Shh), a signaling molecule secreted by the "Zone of Polarizing Activity", an organizer tissue located in the posterior margin of the limb bud. We hav
Externí odkaz:
https://doaj.org/article/4c96b1b3baa3423aa131d41300f4510e
Publikováno v:
bioRxiv
The forkhead box transcription factor genesFoxc1andFoxc2are expressed in the condensing mesenchyme of the developing skeleton prior to the onset of chondrocyte differentiation. To determine the roles of these transcription factors in limb development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081bceaeffb7de786c40a956f04c5707
https://doi.org/10.1101/2023.04.26.538325
https://doi.org/10.1101/2023.04.26.538325
Autor:
Akira Hara, Haruhiko Akiyama, Andrew B. Lassar, Kentaro Takeuchi, Kazu Matsumoto, Hiroyasu Ogawa, Norishige Kuramitsu, Atsushi Goto, Keisuke Akaike, Yoshiyuki Suehara, Hitomi Aoki
Publikováno v:
Osteoarthritis Cartilage
Summary Objective Low molecular weight compounds that reduce the expression of MMP13 at the mRNA level might serve as disease-modifying osteoarthritis (OA) drugs (DMOADs). The objective of this study was to identify a candidate DMOAD that targets MMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db089a3c3a334c4013012583d978511d
https://doi.org/10.1016/j.joca.2021.08.001
https://doi.org/10.1016/j.joca.2021.08.001
Autor:
Deepak Kumar, Andrew B. Lassar
Publikováno v:
Cell Reports, Vol 8, Iss 5, Pp 1419-1431 (2014)
The formation of cartilage is restricted to the core of the limb bud mesenchyme by ectodermal Wnts, which can irreversibly silence expression of the prochondrogenic transcription factor Sox9. In contrast, fibroblast growth factor (FGF) signals from t
Externí odkaz:
https://doaj.org/article/713daba671ae4e798a615f3250d7d122
Autor:
Nicole Bell, Sanket Bhagat, Shanmugam Muruganandan, Ryunhyung Kim, Kailing Ho, Rachel Pierce, Elena Kozhemyakina, Andrew B. Lassar, Laura Gamer, Vicki Rosen, Andreia M. Ionescu
Publikováno v:
Bone
We previously found that FoxA factors are necessary for chondrocyte differentiation. To investigate whether FoxA factors alone are sufficient to drive chondrocyte hypertrophy, we build a FoxA2 transgenic mouse in which FoxA2 cDNA is driven by a reite
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebe91795a816215ab4af7e187ea176a
https://pubmed.ncbi.nlm.nih.gov/35398294
https://pubmed.ncbi.nlm.nih.gov/35398294
Autor:
Ramesh A. Shivdasani, Han-Hwa Hung, Kristina Holton, Alan J. Grodzinsky, Unmesh Jadhav, Cheng-Hai Zhang, Yao Gao, Andrew B. Lassar
A hallmark of cells comprising the superficial zone of articular cartilage is their expression of lubricin, encoded by thePrg4gene, that lubricates the joint and protects against the development of arthritis. Here, we identify Creb5 as a transcriptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::441983fbb90941d3e66e89f03cea8a68
https://doi.org/10.1101/2020.08.12.248609
https://doi.org/10.1101/2020.08.12.248609
Publikováno v:
Nature communications. 13(1)
While prior work has established that articular cartilage arises from Prg4-expressing perichondrial cells, it is not clear how this process is specifically restricted to the perichondrium of synovial joints. We document that the transcription factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0e4f463d8a16edb80db5db4f2878f65
https://pubmed.ncbi.nlm.nih.gov/36435829
https://pubmed.ncbi.nlm.nih.gov/36435829
Autor:
Andrew B. Lassar, Alan J. Grodzinsky, Han-Hwa Hung, Kristina Holton, Yao Gao, Ramesh A. Shivdasani, Unmesh Jadhav, Cheng-Hai Zhang
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
A hallmark of cells comprising the superficial zone of articular cartilage is their expression of lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the development of arthritis. Here, we identify Creb5 as a transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6544a5619fa68e48cf121262f147002d
https://pubmed.ncbi.nlm.nih.gov/33712729
https://pubmed.ncbi.nlm.nih.gov/33712729
Autor:
Hong Qian, Matthew L. Warman, Jozef Kaiser, Thibault Bouderlique, Lei Li, Phillip T Newton, Andrei S. Chagin, Andrew B. Lassar, Marie Šejnohová, Igor Adameyko, Elena Kozhemyakina, Meng Xie, Vyacheslav Dyachuk, Björn Barenius, Tomáš Zikmund, Jan Krivanek
Publikováno v:
The FASEB Journal. 31:1067-1084
Articular cartilage has little regenerative capacity. Recently, genetic lineage tracing experiments have revealed chondrocyte progenitors at the articular surface. We further characterized these progenitors by using in vivo genetic approaches. Histon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b31be76e1fa3fb9cfa6c8bb0cad2e2d
https://doi.org/10.1096/fj.201600918r
https://doi.org/10.1096/fj.201600918r
Autor:
Forest Lai, Mieno Shiraishi, Tso-Pang Yao, Shigeki Nishimori, Elena Kozhemyakina, Andrew B. Lassar, Henry M. Kronenberg, Tatsuya Kobayashi
Publikováno v:
JCI Insight. 4
During endochondral bone formation, chondrocyte hypertrophy represents a crucial turning point from chondrocyte differentiation to bone formation. Both parathyroid hormone-related protein (PTHrP) and histone deacetylase 4 (HDAC4) inhibit chondrocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3744f60d23521f907303b882c829956
https://doi.org/10.1172/jci.insight.97903
https://doi.org/10.1172/jci.insight.97903