Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Andrew B Goryachev"'
Patterning and Morphogenesis From Cells to Organisms: Progress, Common Principles and New Challenges
Autor:
Andrew B. Goryachev, Moisés Mallo
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Externí odkaz:
https://doaj.org/article/604ded26fe014cf4b75df4ca6fd64e10
Publikováno v:
iScience, Vol 8, Iss , Pp 222-235 (2018)
Summary: Centrioles, the cores of centrosomes and cilia, duplicate every cell cycle to ensure their faithful inheritance. How only a single procentriole is produced on each mother centriole remains enigmatic. We propose the first mechanistic biophysi
Externí odkaz:
https://doaj.org/article/f996421304214c45a7b9a4f17a3c029b
Autor:
Andrew B. Goryachev, Marcin Leda
Publikováno v:
F1000Research, Vol 8 (2019)
Small GTPases are organizers of a plethora of cellular processes. The time and place of their activation are tightly controlled by the localization and activation of their regulators, guanine-nucleotide exchange factors (GEFs) and GTPase-activating p
Externí odkaz:
https://doaj.org/article/f5c7d9f0345e423d9d5a6db02ee2fc71
Autor:
Ye Dee Tay, Marcin Leda, Christos Spanos, Juri Rappsilber, Andrew B. Goryachev, Kenneth E. Sawin
Publikováno v:
Cell Reports, Vol 26, Iss 6, Pp 1654-1667.e7 (2019)
Summary: NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity by regulating the Cdc42 guanine nucleotide exchange factor Gef
Externí odkaz:
https://doaj.org/article/89e89c621b12403fa7324cf1ed48c3ef
Autor:
Kirstine Lavrsen, Girish Rajendraprasad, Marcin Leda, Susana Eibes, Elisa Vitiello, Vasileios Katopodis, Andrew B. Goryachev, Marin Barisic
Publikováno v:
Lavrsen, K, Rajendraprasad, G, Leda, M, Eibes, S, Vitiello, E, Katopodis, V, Goryachev, A B & Barisic, M 2023, ' Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration ', Proceedings of the National Academy of Sciences, vol. 120, no. 22, e2300322120 . https://doi.org/10.1073/pnas.2300322120
To initiate directed movement, cells must become polarized, establishing a protrusive leading edge and a contractile trailing edge. This symmetry-breaking process involves reorganization of cytoskeleton and asymmetric distribution of regulatory molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4779f9bf9eaf0c087bbbeb95ccf063b
https://www.pure.ed.ac.uk/ws/files/348350550/pnas.2300322120.pdf
https://www.pure.ed.ac.uk/ws/files/348350550/pnas.2300322120.pdf
Autor:
Andrew B. Goryachev
Publikováno v:
Cells, Vol 10, Iss 1, p 86 (2021)
The concept of “symmetry breaking” has become a mainstay of modern biology, yet you will not find a definition of this concept specific to biological systems in Wikipedia [...]
Externí odkaz:
https://doaj.org/article/0fb9d92d7aff449e9b1a5e68e2d5a8a6
Autor:
Andrew B. Goryachev, Marcin Leda
Publikováno v:
Cells, Vol 9, Iss 9, p 2011 (2020)
Cellular morphogenesis is governed by the prepattern based on the symmetry-breaking emergence of dense protein clusters. Thus, a cluster of active GTPase Cdc42 marks the site of nascent bud in the baker’s yeast. An important biological question is
Externí odkaz:
https://doaj.org/article/d31e80c5275b492097dbe0aaa414c643
Autor:
Jennifer Landino, Marcin Leda, Ani Michaud, Zachary T. Swider, Mariah Prom, Christine M. Field, William M. Bement, Anthony Vecchiarelli, Andrew B. Goryachev, Ann L. Miller
Publikováno v:
Biophysical Journal. 122:167a-168a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a533cfa66fd5cbf838a3fc684a37daee
https://doi.org/10.1016/j.bpj.2022.11.1053
https://doi.org/10.1016/j.bpj.2022.11.1053
Autor:
Zachary T. Swider, Ann L. Miller, George von Dassow, Ani Michaud, Andrew B. Goryachev, William M. Bement, Marcin Leda, Jennifer Landino
Publikováno v:
Curr Biol
Michaud, A, Swider, Z T, Landino, J, Leda, M, Miller, A L, von Dassow, G, Goryachev, A B & Bement, W M 2021, ' Cortical excitability and cell division ', Current Biology, vol. 31, no. 10, pp. PR553-R559 . https://doi.org/10.1016/j.cub.2021.02.053
Michaud, A, Swider, Z T, Landino, J, Leda, M, Miller, A L, von Dassow, G, Goryachev, A B & Bement, W M 2021, ' Cortical excitability and cell division ', Current Biology, vol. 31, no. 10, pp. PR553-R559 . https://doi.org/10.1016/j.cub.2021.02.053
As the interface between the cell and its environment, the cell cortex must be able to respond to a variety of external stimuli. This is made possible in part by cortical excitability, a behavior driven by coupled positive and negative feedback loops
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc12fae112c84f59580367eb4d1feaee
https://doi.org/10.1016/j.cub.2021.02.053
https://doi.org/10.1016/j.cub.2021.02.053
Autor:
Ani Michaud, Marcin Leda, Zachary T. Swider, Songeun Kim, Jiaye He, Jennifer Landino, Jenna R. Valley, Jan Huisken, Andrew B. Goryachev, George von Dassow, William M. Bement
Publikováno v:
Michaud, A, Leda, M, Swider, Z T, Kim, S, He, J, Landino, J, Valley, J R, Huisken, J, Goryachev, A B, von Dassow, G & Bement, W M 2022, ' A versatile cortical pattern-forming circuit based on Rho, F-actin, Ect2 and RGA-3/4 ', Journal of Cell Biology, vol. 221, no. 8, e202203017 . https://doi.org/10.1083/jcb.202203017
Many cells can generate complementary traveling waves of actin filaments (F-actin) and cytoskeletal regulators. This phenomenon, termed cortical excitability, results from coupled positive and negative feedback loops of cytoskeletal regulators. The n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca9b7bae8d5f417516ef7569b70c78e1
https://doi.org/10.1083/jcb.202203017
https://doi.org/10.1083/jcb.202203017