Výsledky vyhledávání - "Andrew B, Kelson"

Synthesis of [14C]anthracycline anticancer agent 14-O-(β-alanyl-N-HCl)-7-O-(2′,6′-dideoxy-2′-fluoro-α-l-talopyranosyl) adriamycinone-14-14C (DA-125-14C)

Autor: Sung W. Rhee, Michael Tracy, Lane A. Clizbe, Jong-Sei Park, Andrew B. Kelson, Jae-Yang Kong, Won-Bae Kim, Jungick Yang, Jung-Koo Roh, Kenneth J. Ryan, Kwang-Dae Ok, Chang Moon-Ho

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 39:773-785

Synthesis of the anthracycline anticancer agent, 14-O(β-alanyl-N-HC)-7-O (2',6'-dideoxy-2'-fluoro-α-L-talopyranosyl) Adriamycinone (DA-125- 14 C) labeled with carbon-14 regiospecifically for ADME (absorption, distribution, metabolism, and excretion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96ec246f5293cc058c910fb416642779
https://doi.org/10.1002/(sici)1099-1344(199709)39:9<773::aid-jlcr21>3.0.co

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Gallium-based anti-infectives: targeting microbial iron-uptake mechanisms

Autor: Vu Truong-Le, Andrew B Kelson, Maia Carnevali

Publikováno v: Current opinion in pharmacology. 13(5)

Microbes have evolved elaborate iron-acquisition systems to sequester iron from the host environment using siderophores and heme uptake systems. Gallium(III) is structurally similar to iron(III), except that it cannot be reduced under physiological c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f8b49f714e464c9cc05b3b2a19df19
https://pubmed.ncbi.nlm.nih.gov/23876838

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Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma

Autor: A. D. Lewis, Eric O. Aboagye, Michael Tracy, Martin A. Graham, Andrew B. Kelson, Paul Workman

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 672:125-132

N-(2-Hydroxy-3,3,3-trifluoropropyl(-2-(2-nitro-1-imidazolyl) acetamide, a novel 2-nitroimidazole is currently being developed as a non-invasive probe for tumour hypoxia. A sensitive minimum quantifiable level = 25 ng/ml; C.V. = 6.01%) and selective a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cce6846abf37e2203a6c1c96fde9d3e
https://doi.org/10.1016/0378-4347(95)00204-v

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Antitumor efficacy and molecular mechanism of TLK58747, a novel DNA-alkylating prodrug

Autor: Hua, Xu, Zhuo, Wang, John C, Donaldson, Hong, Yao, Siqun, Zhou, Andrew B, Kelson, Wenli, Ma, Kevin T, Weber, Edgardo, Laborde, Mingshan, Cheng, Lidia, Sambucetti, James G, Keck

Publikováno v: Anticancer research. 29(10)

DNA-damaging agents are widely used for the treatment of human malignancies. Agents containing the multifunctional alkylating moiety tetrakis(2-chloroethyl)phosphorodiamidic acid are currently under development as cancer therapeutics.TLK58747, a phop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::feabf9394ff7e8b99c1efb2e6a7170e2
https://pubmed.ncbi.nlm.nih.gov/19846918

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Efficient synthesis of trisubstituted pyrazoles and isoxazoles using a traceless 'catch and release' solid-phase strategy

Autor: Brian T. Peterson, Edgardo Laborde, Andrew B. Kelson, Wenli Ma

Publikováno v: Journal of combinatorial chemistry. 11(4)

An efficient three-component, two-step “catch and release” solid-phase synthesis of 3,4,5-trisubstituted pyrazoles and isoxazoles has been developed. The first step involves a base-promoted condensation of a 2-sulfonyl- or a 2-carbonyl-acetonitri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d02cb253ae882b8b14190d5cbfd0e5a4
https://pubmed.ncbi.nlm.nih.gov/19459688

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Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors

Autor: John W. Lewis, Lawrence Toll, Peter Grundt, Cris M. Olsen, Nurulain T. Zaveri, Andrew B. Kelson, Willma E. Polgar

Publikováno v: European journal of pharmacology. 428(1)

Nociceptin/orphanin FQ (N/OFQ) was recently identified as the endogenous ligand for the opioid-receptor like (ORL1) receptor. Although the ORL1 receptor shows sequence homology with the opioid receptors, the nociceptin/ORL1 ligand-receptor system has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6be28164dc2093b9d1d14d384d102eff
https://pubmed.ncbi.nlm.nih.gov/11779034

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Asymmetric synthesis via acetal templates. 15. The preparation of enantiomerically pure mevinolin analogs

Autor: Andrew B. Kelson, William S. Johnson, John D. Elliott

Publikováno v: Tetrahedron Letters. 29:3757-3760

An efficient asymmetric synthesis of the hydroxylactone moiety of mevinolin 1 is described. The key step is the TiCl 4 -catalyzed coupling reaction of acetals 3a and 3b derived from (R)-1,3-butanediol with 1,3-bis(trimethylsilyloxy)-1-methoxybuta-1,3

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c582b2136866f5e2df2a133495481dd
https://doi.org/10.1016/s0040-4039(00)82107-3

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Autor: Andrew B. Kelson, Malcolm N. Palfreyman, John D. Elliott, Neil Purcell, Richard J. Stoodley

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2441

(3R,4S,5R)-3,4-O-Cyclohexylidene-3,4,5-trihydroxycyclohexan-1-one (11a), prepared from D-quinic acid (4a) by a published three-step sequence, was converted into the 5-O-benzoyl derivative (11b) by the action of benzoyl chloride. Simultaneous protecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86e60dc4cbad45f7c5bb94239489eed0
https://doi.org/10.1039/p19830002441

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