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Autor:
Wen Zhou, Brian Gadbaw, Savita Bharathy, Taoufik Ouatas, Andrew Avigdor Butler, Felix Huth, Vassilios Aslanis, Kenichi Umehara
Publikováno v:
Cancer Chemotherapy and Pharmacology. 84:749-757
Ruxolitinib is metabolized by cytochrome P450 (CYP)3A4 and CYP2C9. Dual inhibitors of these enzymes (like fluconazole) lead to increased ruxolitinib exposure relative to a single pathway inhibition of CYP3A4 or CYP2C9. The magnitude of this interacti