Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Andrew A. Welcher"'
Autor:
Heekyong R. Bae, Michael Boedigheimer, Seon Min Jeon, Richard A. Fravell, Patrick S.C. Leung, Michael A. Damore, Giorgio Trinchieri, M. Eric Gershwin, Howard A. Young, Deborah L. Hodge, Vishal Thovarai, Andrew A. Welcher, John M. Fenimore, Amiran Dzutsev, Myung-Sook Choi
Publikováno v:
J Autoimmun
Low grade, chronic inflammation is a critical risk factor for immunologic dysfunction including autoimmune diseases. However, the multiplicity of complex mechanisms and lack of relevant murine models limit our understanding of the precise role of chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd2452976d050026fa9c2bd879973db
https://escholarship.org/uc/item/38j5c3wc
https://escholarship.org/uc/item/38j5c3wc
Autor:
Bryan S Clay, Rebecca A Shilling, Hozefa S Bandukwala, Tamson V Moore, Judy L Cannon, Andrew A Welcher, Joel V Weinstock, Anne I Sperling
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7525 (2009)
Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5' promoter in humans is associated with increased atopy and serum IgE in a founder
Externí odkaz:
https://doaj.org/article/f7b468f8afff45d897881ab69bf6ac1c
Autor:
Kevin Latinis, Michael Boedigheimer, Lovely Goyal, Zahir Amoura, Winnie Sohn, Christopher Banfield, Kelly S. Oliner, Andrew A. Welcher, James B. Chung, Michael A. Damore, Gregory E. Arnold, Kit Chiu, Alla Rudinskaya, Narendra Chirmule, Jill P. Buyon, Alan Kivitz
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective To assess the safety and immunologic impact of inhibiting interferon-γ (IFNγ) with AMG 811, a human IgG1 monoclonal antibody against IFNγ, in patients with systemic lupus erythematosus (SLE). Methods Twenty-six patients with mild-to-mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab10c99c384e4494658239585ade22a7
https://doi.org/10.1002/art.39248
https://doi.org/10.1002/art.39248
Autor:
Juan Jose Perez Ruixo, Ping Chen, Thuy Vu, Barbara A. Sullivan, Winnie Sohn, Andrew A. Welcher, Michael Boedigheimer, David Martin, Adimoolam Narayanan, Peiming Ma, Jin Wang
Publikováno v:
Pharmaceutical Research. 32:640-653
To investigate the relationships between AMG 811 exposure, concentration changes in serum IFN-γ, and IFN-γ-induced protein 10 (CXCL10), and to identify important contributions of baseline covariates to these relationships. A mechanism based pharmac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81206946676d57f3e1468d5e40e177f0
https://doi.org/10.1007/s11095-014-1492-2
https://doi.org/10.1007/s11095-014-1492-2
Autor:
Wen Yu, Paul Skipp, Ratko Djukanovic, Ana R. Sousa, Graham Roberts, Kian Fan Chung, Martin Timour, Xuguang Hu, Lori Twehues, Peter J. Sterk, Julie Corfield, Ian M. Adcock, Michael Boedigheimer, James P.R. Schofield, Andrew A. Welcher, Bertrand De Meulder, Anthony Rowe, Diane Lefaudeux, Charles Auffray, Jeannette Bigler
Publikováno v:
American journal of respiratory and critical care medicine, 195(10), 1311-1320. American Thoracic Society
Stratification of asthma at the molecular level, especially using accessible biospecimens, could greatly enable patient selection for targeted therapy. To determine the value of blood analysis to identify transcriptional differences between clinicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b62fe32b6a643d5654a683aa6d2a40c9
http://hdl.handle.net/10044/1/42697
http://hdl.handle.net/10044/1/42697
Autor:
David Fiorentino, Michael Boedigheimer, Andrew A. Welcher, Michael A. Damore, Victoria P. Werth, James B. Chung, David Martin, Barbara A. Sullivan, Gregory E. Arnold, Chris B. Russell, Jeannette Bigler, Christine Wang, Kit Chiu
Publikováno v:
Arthritis & Rheumatology (Hoboken, N.j.)
Objective Interferon-γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811, an anti-IFNγ antibody, in patients with DLE. Methods The study was designed as a phase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3c5ff9c9628ea210991ccb02b33a20
https://pubmed.ncbi.nlm.nih.gov/28118537
https://pubmed.ncbi.nlm.nih.gov/28118537
Autor:
Natalia Leshinsky, Gary Means, Scott D. Patterson, William A. Rees, Geoffrey S. Diemer, Kathryn J. Newhall, Andrew A. Welcher, Hilary T. Chute, Chris B. Russell, Keith Kerkof
Publikováno v:
Clinical Chemistry. 56:1483-1491
BACKGROUND Biomarker assays are often conducted on whole blood samples in the course of drug development studies. Because bacterial lipopolysaccharide (LPS) (endotoxin) contamination is known to cause spontaneous cytokine production by monocytes, con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee736a60a535e227915cad721ea97ad1
https://doi.org/10.1373/clinchem.2006.144618
https://doi.org/10.1373/clinchem.2006.144618
Autor:
Richard A. Flavell, Tom Horan, Joel V. Weinstock, Bryan S. Clay, Elizabeth Berry, Tiffany Lu, Anne I. Sperling, Andrew A. Welcher, Steve K. Yoshinaga, Jianlcun Tong, Rebecca A. Shilling, Amanda G. Tesciuba, Tamson V. Moore, Judy L. Cannon, Hozefa S. Bandukwala
Publikováno v:
Cellular Immunology. 259:177-184
Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a82d819a1f54735bf2aea12bc24fc7f8
https://doi.org/10.1016/j.cellimm.2009.06.013
https://doi.org/10.1016/j.cellimm.2009.06.013
Autor:
Tamson V. Moore, Rebecca A. Shilling, Anne I. Sperling, Andrew A. Welcher, Joel V. Weinstock, Bryan S. Clay, Monica D. Agarwal, Amanda G. Tesciuba, Hozefa S. Bandukwala
Publikováno v:
The Journal of Immunology. 181:1019-1024
The T cell costimulatory molecule ICOS regulates Th2 effector function in allergic airway disease. Recently, several studies with ICOS−/− mice have also demonstrated a role for ICOS in Th2 differentiation. To determine the effects of ICOS on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4044852511c67c4a1435e5fd2e35acb8
https://doi.org/10.4049/jimmunol.181.2.1019
https://doi.org/10.4049/jimmunol.181.2.1019
Autor:
Kurt Morgenstern, Matthew W. Martin, Faye Hsieh, Stuart C. Chaffee, Susan A. Tomlinson, Susan M. Turci, Joseph J. Nunes, Lilly Chai, Paul E. Rose, Josie H. Lee, Antonio J. Oliveira-dos-Santos, Erin F. DiMauro, Vinod F. Patel, David Powers, Yan Gu, Xin Huang, Jean Bemis, Andrew A. Welcher, David C. Mcgowan, Huilin Zhao, Joseph L. Kim, Xiaotian Zhu, Holly L. Deak, Li Zhu, Yanyan Tudor, Ted Faust, Linda F. Epstein, Christina Boucher, Anu Gore, Deanna Mohn, Stephen Schneider, John Newcomb, Daniela Metz, Brad Henkle, Paul Gallant
Publikováno v:
Journal of Medicinal Chemistry. 51:1681-1694
The lymphocyte-specific kinase (Lck), a member of the Src family of cytoplasmic tyrosine kinases, is expressed in T cells and natural killer (NK) cells. Genetic evidence, including knockout mice and human mutations, demonstrates that Lck kinase activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8884d0e69b4d85c6e3a74c4f98b0f
https://doi.org/10.1021/jm7010996
https://doi.org/10.1021/jm7010996