Zobrazeno 1 - 10
of 2 178
pro vyhledávání: '"Andrew A. Morris"'
Autor:
Yi Shiau Ng, Nichola Z. Lax, Paul Maddison, Charlotte L. Alston, Emma L. Blakely, Philippa D. Hepplewhite, Gillian Riordan, Surita Meldau, Patrick F. Chinnery, Germaine Pierre, Efstathia Chronopoulou, Ailian Du, Imelda Hughes, Andrew A. Morris, Smaragda Kamakari, Georgia Chrousos, Richard J. Rodenburg, Christiaan G.J. Saris, Catherine Feeney, Steven A. Hardy, Takafumi Sakakibara, Akira Sudo, Yasushi Okazaki, Kei Murayama, Helen Mundy, Michael G. Hanna, Akira Ohtake, Andrew M. Schaefer, Mike P. Champion, Doug M. Turnbull, Robert W. Taylor, Robert D.S. Pitceathly, Robert McFarland, Gráinne S. Gorman
Publikováno v:
EBioMedicine, Vol 30, Iss , Pp 86-93 (2018)
Mutations in the m.13094T>C MT-ND5 gene have been previously described in three cases of Leigh Syndrome (LS). In this retrospective, international cohort study we identified 20 clinically affected individuals (13 families) and four asymptomatic carri
Externí odkaz:
https://doaj.org/article/3670bb9d88df4ad19193530872b41183
Autor:
Stavros Stivaros, Shruti Garg, Maria Tziraki, Ying Cai, Owen Thomas, Joseph Mellor, Andrew A. Morris, Carly Jim, Karolina Szumanska-Ryt, Laura M Parkes, Hamied A. Haroon, Daniela Montaldi, Nicholas Webb, John Keane, Francisco X. Castellanos, Alcino J. Silva, Sue Huson, Stephen Williams, D. Gareth Evans, Richard Emsley, Jonathan Green, SANTA Consortium
Publikováno v:
Molecular Autism, Vol 9, Iss 1, Pp 1-13 (2018)
Abstract Background Neurofibromatosis 1 (NF1) is a monogenic model for syndromic autism. Statins rescue the social and cognitive phenotype in animal knockout models, but translational trials with subjects > 8 years using cognition/behaviour outcomes
Externí odkaz:
https://doaj.org/article/dafd5e775ca6491c9657b16a73c4e0fa
Autor:
Jennifer Shuldiner, Meagan Lacroix, Marianne Saragosa, Catherine Reis, Kevin L. Schwartz, Sharon Gushue, Valerie Leung, Jeremy Grimshaw, Michael Silverman, Kednapa Thavorn, Jerome A. Leis, Michael Kidd, Nick Daneman, Mina Tradous, Bradley Langford, Andrew M. Morris, Jonathan Lam, Gary Garber, Jamie Brehaut, Monica Taljaard, Michelle Greiver, Noah Michael Ivers
Publikováno v:
Implementation Science, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Background Unnecessary antibiotic prescriptions in primary care are common and contribute to antimicrobial resistance in the population. Audit and feedback (A&F) on antibiotic prescribing to primary care can improve the appropriateness of an
Externí odkaz:
https://doaj.org/article/ba469a9457c94237849a68d2f6b4dcb7
Autor:
Pedro Póvoa, Luís Coelho, José Pedro Cidade, Adrian Ceccato, Andrew Conway Morris, Jorge Salluh, Vandack Nobre, Saad Nseir, Ignacio Martin-Loeches, Thiago Lisboa, Paula Ramirez, Anahita Rouzé, Daniel A. Sweeney, Andre C. Kalil
Publikováno v:
Annals of Intensive Care, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Severe acute respiratory infections, such as community-acquired pneumonia, hospital-acquired pneumonia, and ventilator-associated pneumonia, constitute frequent and lethal pulmonary infections in the intensive care unit (ICU). Despite optima
Externí odkaz:
https://doaj.org/article/68dad71ce7d6469ca7be4b5410caf1b3
Autor:
Tinashe Chikowore, Kristi Läll, Lisa K. Micklesfield, Zane Lombard, Julia H. Goedecke, Segun Fatumo, Shane A. Norris, Reedik Magi, Michele Ramsay, Paul W. Franks, Guillaume Pare, Andrew P. Morris
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Polygenic prediction studies in continental Africans are scarce. Africa’s genetic and environmental diversity pose a challenge that limits the generalizability of polygenic risk scores (PRS) for body mass index (BMI) within the
Externí odkaz:
https://doaj.org/article/825d36976194427aa422588375cc1fb5
Autor:
Hannah Wozniak, Alexis Tabah, François Barbier, Stéphane Ruckly, Ambre Loiodice, Murat Akova, Marc Leone, Andrew Conway Morris, Matteo Bassetti, Kostoula Arvaniti, Ricard Ferrer, Liesbet de Bus, Jose Artur Paiva, Hendrik Bracht, Adam Mikstacki, Adel Alsisi, Liana Valeanu, Josef Prazak, Jean-François Timsit, Niccolò Buetti, on behalf of the EUROBACT-2 Study Group, ESICM, ESCMID ESGCIP and the OUTCOMEREA Network
Publikováno v:
Annals of Intensive Care, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Background Hospital-acquired bloodstream infections are common in the intensive care unit (ICU) and have a high mortality rate. Patients with cirrhosis are especially susceptible to infections, yet there is a knowledge gap in the epidemiolog
Externí odkaz:
https://doaj.org/article/fe09467495ba4b089af4f17200897ee6
Autor:
Passent Helal, Wangmingyu Xia, Puspendu Sardar, Anna Conway‐Morris, Andrew Conway‐Morris, Virginia A. Pedicord, Jaco Serfontein
Publikováno v:
Brain and Behavior, Vol 14, Iss 9, Pp n/a-n/a (2024)
Abstract Objective Anorexia nervosa has the highest mortality rate among psychiatric illnesses. Current treatments remain ineffective for a large fraction of patients. This may be due to unclear mechanisms behind its development and maintenance. Stud
Externí odkaz:
https://doaj.org/article/f4487b362ef04d4d9e7763c63a8a052b
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 40, Iss , Pp 101104- (2024)
Several disorders of energy metabolism have been treated with exogenous ketone bodies. The benefit of this treatment is best documented in multiple acyl-CoA dehydrogenase deficiency (MADD) (MIM#231680). One might also expect ketone bodies to help in
Externí odkaz:
https://doaj.org/article/32f54e43788e41bc887af62801f681ab
Autor:
Xiaoguang Xu, Chachrit Khunsriraksakul, James M. Eales, Sebastien Rubin, David Scannali, Sushant Saluja, David Talavera, Havell Markus, Lida Wang, Maciej Drzal, Akhlaq Maan, Abigail C. Lay, Priscilla R. Prestes, Jeniece Regan, Avantika R. Diwadkar, Matthew Denniff, Grzegorz Rempega, Jakub Ryszawy, Robert Król, John P. Dormer, Monika Szulinska, Marta Walczak, Andrzej Antczak, Pamela R. Matías-García, Melanie Waldenberger, Adrian S. Woolf, Bernard Keavney, Ewa Zukowska-Szczechowska, Wojciech Wystrychowski, Joanna Zywiec, Pawel Bogdanski, A. H. Jan Danser, Nilesh J. Samani, Tomasz J. Guzik, Andrew P. Morris, Dajiang J. Liu, Fadi J. Charchar, Human Kidney Tissue Resource Study Group, Maciej Tomaszewski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-29 (2024)
Abstract Genetic mechanisms of blood pressure (BP) regulation remain poorly defined. Using kidney-specific epigenomic annotations and 3D genome information we generated and validated gene expression prediction models for the purpose of transcriptome-
Externí odkaz:
https://doaj.org/article/f5e9da19c88d4024b4071ce5130ced06
Autor:
Ana Luiza Arruda, Golam M. Khandaker, Andrew P. Morris, George Davey Smith, Laura M. Huckins, Eleftheria Zeggini
Publikováno v:
Schizophrenia, Vol 10, Iss 1, Pp 1-12 (2024)
Abstract Multimorbidity represents an increasingly important public health challenge with far-reaching implications for health management and policy. Mental health and metabolic diseases have a well-established epidemiological association. In this st
Externí odkaz:
https://doaj.org/article/3b75b79866b845a5a6b0e06d19062b74