Zobrazeno 1 - 10
of 1 270
pro vyhledávání: '"Andrew A. Green"'
Autor:
Shristi Bhattarai, Manali Rupji, Hsueh-ping Chao, Qi Xu, Geetanjali Saini, Padmashree Rida, Mohammed A. Aleskandarany, Andrew R. Green, Ian O. Ellis, Emiel A. Janssen, Kristin Jonsdottir, Emad Rakha, Jeanne Kowalski, Ritu Aneja
Publikováno v:
BJC Reports, Vol 2, Iss 1, Pp 1-10 (2024)
Abstract Background Ki67 index (KI) and mitotic index (MI) are proliferation markers with established prognostic value in breast carcinomas. While KI is evaluated immunohistochemically and reported as a percentage, MI is determined visually and refle
Externí odkaz:
https://doaj.org/article/8feb79c71f7142a48c824535a1a38430
Autor:
Corinne L. Woodcock, Mansour Alsaleem, Michael S. Toss, Jennifer Lothion-Roy, Anna E. Harris, Jennie N. Jeyapalan, Nataliya Blatt, Albert A. Rizvanov, Regina R. Miftakhova, Yousif A. Kariri, Srinivasan Madhusudan, Andrew R. Green, Catrin S. Rutland, Rupert G. Fray, Emad A. Rakha, Nigel P. Mongan
Publikováno v:
Discover Oncology, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Background N6-methyladenosine (m6A) is the most common internal RNA modification and is involved in regulation of RNA and protein expression. AlkB family member 5 (ALKBH5) is a m6A demethylase. Given the important role of m6A in biological m
Externí odkaz:
https://doaj.org/article/8fdaac6eb0dd41889920c42b595de135
Autor:
Tanjina Kader, Elena Provenzano, Madawa W. Jayawardana, Shona Hendry, Jia-Min Pang, Kenneth Elder, David J. Byrne, Lauren Tjoeka, Helen ML. Frazer, Eloise House, Sureshni I. Jayasinghe, Holly Keane, Anand Murugasu, Neeha Rajan, Islam M. Miligy, Michael Toss, Andrew R. Green, Emad A. Rakha, Stephen B. Fox, G. Bruce Mann, Ian G. Campbell, Kylie L. Gorringe
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-10 (2024)
Abstract Various histopathological, clinical and imaging parameters have been evaluated to identify a subset of women diagnosed with lesions with uncertain malignant potential (B3 or BIRADS 3/4A lesions) who could safely be observed rather than being
Externí odkaz:
https://doaj.org/article/b48a3f6e9ea54a189ccefd102db6473b
Autor:
Behnaz Saidy, Richa Vasan, Rosie Durant, Megan-Rose Greener, Adelynn Immanuel, Andrew R. Green, Emad Rakha, Ian Ellis, Graham Ball, Stewart G. Martin, Sarah J. Storr
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract DARPP-32 is a key regulator of protein-phosphatase-1 (PP-1) and protein kinase A (PKA), with its function dependent upon its phosphorylation state. We previously identified DKK1 and GRB7 as genes with linked expression using Artificial Neura
Externí odkaz:
https://doaj.org/article/8c1ee39167a0487ca4d3a7902d3e505d
Autor:
Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Ake Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline A. Drukker, Annuska M. Glas, Andrew R. Green, Edoardo Isnaldi, Jórunn Eyfjörð, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil R. Lakhani, Anita Langerod, John W. M. Martens, Amy E. McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad A. Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter T. Simpson, Marjanka K. Schmidt, Christos Sotiriou, Paul N. Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc Van de Vijver, Steven Van Laere, Laura van’t Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke T. Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek D. Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard, Christine Desmedt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of untreated primary BC di
Externí odkaz:
https://doaj.org/article/449fce543ad84736bc9d60953aa2df60
Autor:
Ayat Lashen, Abdulbaqi Al-Kawaz, Jennie N Jeyapalan, Shatha Alqahtani, Ahmed Shoqafi, Mashael Algethami, Michael Toss, Andrew R Green, Nigel P Mongan, Sudha Sharma, Mohammad R Akbari, Emad A Rakha, Srinivasan Madhusudan
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 47, Iss , Pp 100957- (2024)
RECQL is essential for genomic stability. Here, we evaluated RECQL in 449 pure ductal carcinomas in situ (DCIS), 152 DCIS components of mixed DCIS/invasive breast cancer (IBC) tumors, 157 IBC components of mixed DCIS/IBC and 50 normal epithelial term
Externí odkaz:
https://doaj.org/article/49f4f85691f14003931c5bd5105aab22
RANK is a poor prognosis marker and a therapeutic target in ER‐negative postmenopausal breast cancer
Autor:
Marina Ciscar, Eva M Trinidad, Gema Perez‐Chacon, Mansour Alsaleem, Maria Jimenez, Maria J Jimenez‐Santos, Hector Perez‐Montoyo, Adrian Sanz‐Moreno, Andrea Vethencourt, Michael Toss, Anna Petit, Maria T Soler‐Monso, Victor Lopez, Jorge Gomez‐Miragaya, Clara Gomez‐Aleza, Lacey E Dobrolecki, Michael T Lewis, Alejandra Bruna, Silvana Mouron, Miguel Quintela‐Fandino, Fatima Al‐Shahrour, Antonio Martinez‐Aranda, Angels Sierra, Andrew R Green, Emad Rakha, Eva Gonzalez‐Suarez
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 4, Pp 1-12 (2023)
Abstract Despite strong preclinical data, the therapeutic benefit of the RANKL inhibitor, denosumab, in breast cancer patients, beyond the bone, is unclear. Aiming to select patients who may benefit from denosumab, we hereby analyzed RANK and RANKL p
Externí odkaz:
https://doaj.org/article/1a7e932a6a184ce6a384d4a58e43a0be
Autor:
Mashael Algethami, Michael S. Toss, Corinne L. Woodcock, Chandar Jaipal, Juliette Brownlie, Ahmed Shoqafi, Adel Alblihy, Katia A. Mesquita, Andrew R. Green, Nigel P. Mongan, Jennie N. Jeyapalan, Emad A. Rakha, Srinivasan Madhusudan
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Replication Protein A (RPA), a heterotrimeric complex consisting of RPA1, 2, and 3 subunits, is a single-stranded DNA (ssDNA)-binding protein that is critically involved in replication, checkpoint regulation and DNA repair. Here we have eval
Externí odkaz:
https://doaj.org/article/c5ad0bb1f1a94ed0a4920ebd299adf4e
Autor:
Radhika Aiyappa‐Maudsley, Sarah J Storr, Emad A Rakha, Andrew R Green, Ian O Ellis, Stewart G Martin
Publikováno v:
The Journal of Pathology: Clinical Research, Vol 8, Iss 6, Pp 550-566 (2022)
Abstract The cytochrome P450 family of enzymes metabolise a wide range of compounds and play important roles in breast cancer pathogenesis due to their involvement in estrogen metabolism and the production of carcinogenic metabolites during this proc
Externí odkaz:
https://doaj.org/article/f4475e0c317e43b4a14ddc6ba556ba65
Autor:
Nicholas Chancellor, Philip J. D. Crowley, Tanja Durić, Walter Vinci, Mohammad H. Amin, Andrew G. Green, Paul A. Warburton, Gabriel Aeppli
Publikováno v:
npj Quantum Information, Vol 8, Iss 1, Pp 1-8 (2022)
Abstract A finite length ferromagnetic chain with opposite spin polarization imposed at its two ends is one of the simplest frustrated spin models. In the clean classical limit the domain wall inserted on account of the boundary conditions resides wi
Externí odkaz:
https://doaj.org/article/3e468eaec6674f89b91cd553472ced75