Zobrazeno 1 - 10
of 1 940
pro vyhledávání: '"Andrew A. Brown"'
Autor:
Andrew A. Brown, Juan J. Fernandez-Tajes, Mun-gwan Hong, Caroline A. Brorsson, Robert W. Koivula, David Davtian, Théo Dupuis, Ambra Sartori, Theodora-Dafni Michalettou, Ian M. Forgie, Jonathan Adam, Kristine H. Allin, Robert Caiazzo, Henna Cederberg, Federico De Masi, Petra J. M. Elders, Giuseppe N. Giordano, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison J. Heggie, Cédric Howald, Angus G. Jones, Tarja Kokkola, Markku Laakso, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Miranda Mourby, Petra B. Musholt, Birgitte Nilsson, Francois Pattou, Deborah Penet, Violeta Raverdy, Martin Ridderstråle, Luciana Romano, Femke Rutters, Sapna Sharma, Harriet Teare, Leen ‘t Hart, Konstantinos D. Tsirigos, Jagadish Vangipurapu, Henrik Vestergaard, Søren Brunak, Paul W. Franks, Gary Frost, Harald Grallert, Bernd Jablonka, Mark I. McCarthy, Imre Pavo, Oluf Pedersen, Hartmut Ruetten, Mark Walker, The DIRECT Consortium, Jerzy Adamski, Jochen M. Schwenk, Ewan R. Pearson, Emmanouil T. Dermitzakis, Ana Viñuela
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype,
Externí odkaz:
https://doaj.org/article/03b888dddec54ecd93647492ab5dd5aa
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D
Autor:
Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda Bennett, Michael Boehnke, Andrew A. Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Paul Johnson, Ulrika Krus, Patrick E. MacDonald, Anubha Mahajan, Jocelyn E. Manning Fox, Narisu Narisu, Vibe Nylander, Peter Orchard, Nikolay Oskolkov, Nikolaos I. Panousis, Anthony Payne, Michael L. Stitzel, Swarooparani Vadlamudi, Ryan Welch, Francis S. Collins, Karen L. Mohlke, Anna L. Gloyn, Laura J. Scott, Emmanouil T. Dermitzakis, Leif Groop, Stephen C. J. Parker, Mark I. McCarthy
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Mechanistic inference following GWAS is hampered by the lack of tissue-specific transcriptomic resources. Here the authors combine genetic variants predisposing to type 2 diabetes with human pancreatic islet RNA-seq data. They identify 7741 islet exp
Externí odkaz:
https://doaj.org/article/1e9cd2a221bf4b5fa3193842e74efdfa
Autor:
Olivier Delaneau, Halit Ongen, Andrew A. Brown, Alexandre Fort, Nikolaos I. Panousis, Emmanouil T. Dermitzakis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Analysis of molecular quantitative trait loci (molQTL) can help interpret genome-wide association studies and requires efficient approaches to correct for multiple testing. This study describes a bioinformatics toolkit called QTLtool that can handle
Externí odkaz:
https://doaj.org/article/3aa3ab4013b84fed9c3eb130c22dcb98
Autor:
Sebastijan Hobor, Maise Al Bakir, Crispin T. Hiley, Marcin Skrzypski, Alexander M. Frankell, Bjorn Bakker, Thomas B. K. Watkins, Aleksandra Markovets, Jonathan R. Dry, Andrew P. Brown, Jasper van der Aart, Hilda van den Bos, Diana Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H. Rabinowitz, Laila Ait Hassou, Saskia Litière, D. Lucas Kerr, Lisa Tan, Gavin Kelly, David A. Moore, Matthew J. Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R. M. Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M. Blakely, Elza C. de Bruin, Floris Foijer, Karen H. Vousden, Trever G. Bivona, TRACERx consortium, Robert E. Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract The phenomenon of mixed/heterogenous treatment responses to cancer therapies within an individual patient presents a challenging clinical scenario. Furthermore, the molecular basis of mixed intra-patient tumor responses remains unclear. Here
Externí odkaz:
https://doaj.org/article/a58c4b29e1d8491b8078212067633916
Autor:
Richard J McManus, Ben Goldacre, David Evans, Alex J Walker, Christopher Wood, Jessica Morley, Brian MacKenna, Christopher T Rentsch, Seb Bacon, Chris Bates, Helen J Curtis, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, Laurie Tomlinson, John Parry, Frank Hester, Amelia Green, Miriam Samuel, Rose Higgins, Andrew D Brown, Viyaasan Mahalingasivam, Caroline Morton, Rebecca M Smith, Louis Fisher, Lisa Hopcroft, Jon Massey, Iain Dillingham, Steven Maude, Milan Wiedemann, Colm Andrews, Christine Cunningham, Victoria Speed, Caroline Walters
Publikováno v:
Open Heart, Vol 11, Iss 2 (2024)
Background The COVID-19 pandemic disrupted cardiovascular disease management in primary care in England.Objective To describe the impact of the pandemic on blood pressure screening and hypertension management based on a national quality of care schem
Externí odkaz:
https://doaj.org/article/def5676c0049471baf29cf83371d4893
Autor:
Ben Goldacre, David Evans, Sam Harper, Richard Croker, Christopher Wood, Brian MacKenna, Elizabeth Beech, Chris Bates, Amir Mehrkar, Peter Inglesby, Jonathan Cockburn, John Parry, Frank Hester, Kieran Hand, Helen Curtis, Rose Higgins, Andrew D Brown, Simon Davy, George Hickman, Tom Ward, Rebecca M Smith, Louis Fisher, Iain Dillingham, Steven Maude, Lucy Bridges, Linda Gough, Christine Cunningham, Victoria Speed, Ben FC Butler-Cole, Sebastian CJ Bacon, Thomas O'Dwyer, Liam C Hart
Publikováno v:
BMJ Medicine, Vol 3, Iss 1 (2024)
Objective To investigate the effect of the covid-19 pandemic on the number of patients with group A streptococcal infections and related antibiotic prescriptions.Design Retrospective cohort study in England using OpenSAFELY-TPP.Setting Primary care p
Externí odkaz:
https://doaj.org/article/76a3f50c7f87442e84bd0cb88b74f1ba
Autor:
Gerardo Malavena, Salvatore M. Amoroso, Andrew R. Brown, Plamen Asenov, Xi-Wei Lin, Victor Moroz, Mattia Giulianini, David Refaldi, Christian Monzio Compagnoni, Alessandro S. Spinelli
Publikováno v:
IEEE Journal of the Electron Devices Society, Vol 12, Pp 651-657 (2024)
In this two-part article we discuss the difference between a continuous and a discrete approach to trap modeling in the simulation of 3-D NAND Flash memories with polysilicon channel. In Part I we focus on threshold voltage $({\mathrm { V}}_{\mathrm
Externí odkaz:
https://doaj.org/article/b7afce161e184ff092a9374d9c9526b5
Autor:
Gerardo Malavena, Salvatore M. Amoroso, Andrew R. Brown, Plamen Asenov, Xi-Wei Lin, Victor Moroz, Mattia Giulianini, David Refaldi, Christian Monzio Compagnoni, Alessandro S. Spinelli
Publikováno v:
IEEE Journal of the Electron Devices Society, Vol 12, Pp 658-661 (2024)
In Part II of this article we discuss the impact of a discrete treatment of traps on 3-D NAND Flash random telegraph noise (RTN). A higher RTN results when discrete traps are taken into account, that can only be explained by a stronger influence of t
Externí odkaz:
https://doaj.org/article/09c859b81e254e71b8dbdeb8f936cf18
Autor:
Christina Zorbas, Miranda R. Blake, Andrew D. Brown, Anna Peeters, Steve Allender, Julie Brimblecombe, Adrian J. Cameron, Jill Whelan, Megan Ferguson, Laura Alston, Tara Boelsen-Robinson
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-16 (2024)
Abstract Background Food retailers can be reluctant to initiate healthy food retail activities in the face of a complex set of interrelated drivers that impact the retail environment. The Systems Thinking Approach for Retail Transformation (START) is
Externí odkaz:
https://doaj.org/article/d1641751b1f04f7d9b5f272d59b48b7a
Publikováno v:
Human Resources for Health, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background This review paper offers a policy-tracing trend analysis of national experiences among low- and middle-income countries in strengthening human resources for health information systems (HRHIS). This paper draws on evidence from the
Externí odkaz:
https://doaj.org/article/b070e2f2e17e4edc884f6b2795d40d7c